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author = "Liu, Yi" > : "Diffraction Structural Biology" (x)
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Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

Description : Crystal structures of protease/inhibitor complexes guided optimization of the buried nonpolar surface area thereby maximizing hydrophobic binding. The resulting potent tripeptide inhibitor is in clinical trials.
Repository : Europe PubMed Central
Language(s) : English
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