Results
author = "Lison, Dominique"
Organochlorines and endometriosis: a mini-review.
Description :
Organochlorines (polychlorinated biphenyls and dioxin-like compounds) are suspected to play a role in the etiopathogenesis of endometriosis. This hypothesis, based on experimental data, has been circulating for years in the scientific community and several epidemiologic surveys have attempted to obt...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Risk of leukaemia among pesticide manufacturing workers: a review and meta-analysis of cohort studies.
Description :
PURPOSE: The purpose of this paper is to review available cohort studies and to estimate quantitatively the association between occupational exposure in plants manufacturing pesticides and leukaemia. METHODS: Following a systematic literature search, relative risks were extracted from 14 studies pub...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes.
Author(s) :
Haufroid, Vincent
,
Ligocka, Danuta
,
Buysschaert, Martin
,
Horsmans, Yves
,
Lison, Dominique
Description :
OBJECTIVE: Cytochrome P4502E1 (CYP2E1) is expressed in human peripheral blood lymphocytes (PBLs), and previous reports have suggested the possibility of using this readily available tissue as a reporter of CYP2E1 status. To further explore the relevance of this approach we assessed CYP2E1 expression...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Cytochrome P4502E1 phenotyping by the measurement of the chlorzoxazone metabolic ratio: assessment of its usefulness in workers exposed to styrene.
Description :
OBJECTIVES: To analyse the relationship between cytochrome P4502E1 (CYP2E1) activity as assessed by the chlorzoxazone metabolic ratio (CMR) and frequent CYP2E1 genotypes ( CYP2E1*5B, *6, *1B and *1D) and to assess the value of CMR in refining the biomonitoring of exposure to styrene. METHODS: Thirty...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Arsenobetaine is not a major metabolite of arsine gas in the rat.
Description :
Many organisms can easily dispose of toxic inorganic arsenic species through gradual methylation of the element and further urinary excretion. In order to clarify the urinary excretion of arsenobetaine observed in a human case of intoxication by arsine, the capacity of highly methylated arsenical sy...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Influence of particle surface area on the toxicity of insoluble manganese dioxide dusts.
Description :
The objective of this study was to examine the influence of specific surface area on the biological activity of insoluble manganese dioxide (MnO2) particles. The biological responses to various MnO2 dusts with different specific surface area (0.16, 0.5, 17 and 62 m2/g) were compared in vitro and in ...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Effect of sulphur mustard on the expression of urokinase in cultured 3T3 fibroblasts.
Description :
The expression of plasminogen activator (PA), a serine proteinase involved in the degradation of extracellular matrix proteins, has been investigated in 3T3 fibroblasts after in vitro exposure to sulphur mustard (SM). Expression of the cell-associated enzyme has been assessed with a synthetic substr...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Effect of the benzene metabolite, hydroquinone, on interleukin-1 secretion by human monocytes in vitro.
Description :
Decreased interleukin-1 (IL-1) production by mononuclear phagocytes has been shown to contribute to benzene myelotoxicity in animals. The study presented here was designed to examine the relevance of this mechanism in humans. Fresh human blood monocytes were exposed to 0.001-10 microM hydroquinone (...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
The delayed lung responses to single and repeated intratracheal administration of pure cobalt and hard metal powder in the rat.
Description :
Epidemiological and clinical studies suggest that inhalation of cobalt metal dust (Co) mixed with tungsten carbide particles (WC), but not of cobalt dust alone, may cause interstitial pulmonary lesions (hard metal disease). In previous experimental studies in the rat, we have demonstrated the greate...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Lung toxicity of hard metal particles and production of interleukin-1, tumor necrosis factor-alpha, fibronectin, and cystatin-c by lung phagocytes.
Description :
Hard metal alloys (WC-Co) are made of a mixture of cobalt (Co; 6%) and tungsten carbide (WC; 94%) particles. Chronic inhalation of hard metal dust can lead to the development of a fibrosing alveolitis, the pathogenesis of which is still undefined. The present investigation was undertaken to assess t...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English