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author = "Lipsitch, Marc"
<< < 3 4 5 6 7 > >>

Found 117 documents, displaying page 5 of 12

Single-Step Capsular Transformation and Acquisition of Penicillin Resistance in Streptococcus pneumoniae

Author(s) : Trzciński, Krzysztof , Thompson, Claudette M. , Lipsitch, Marc
Description : The capsule (cps) locus of Streptococcus pneumoniae is flanked by the pbp2x and pbp1a genes, coding for penicillin-binding proteins, enzymes involved in cell wall synthesis that are targets for β-lactams. This linkage suggested to us that selection for β-lactam resistance might coselect for capsular...
Repository : Europe PubMed Central
Language(s) : English

Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals

Author(s) : Bergstrom, Carl T. , Lo, Monique , Lipsitch, Marc
Description : Hospital-acquired infections caused by antibiotic-resistant bacteria pose a grave and growing threat to public health. Antimicrobial cycling, in which two or more antibiotic classes are alternated on a time scale of months to years, seems to be a leading candidate in the search for treatment strateg...
Repository : Europe PubMed Central
Language(s) : English

Public health interventions and epidemic intensity during the 1918 influenza pandemic

Author(s) : Hatchett, Richard J. , Mecher, Carter E. , Lipsitch, Marc
Description : Nonpharmaceutical interventions (NPIs) intended to reduce infectious contacts between persons form an integral part of plans to mitigate the impact of the next influenza pandemic. Although the potential benefits of NPIs are supported by mathematical models, the historical evidence for the impact of ...
Repository : Europe PubMed Central
Language(s) : English

Impaired Innate and Adaptive Immunity to Streptococcus pneumoniae and Its Effect on Colonization in an Infant Mouse Model ▿

Author(s) : Bogaert, Debby , Weinberger, Daniel , Thompson, Claudette , Lipsitch, Marc , Malley, Richard
Description : Streptococcus pneumoniae colonization and invasive disease peak around the third and first birthdays, respectively, and decline thereafter. While these declines are attributable in part to immunity acquired via natural exposure, maturation of innate immune responses may also be involved. A mucosally...
Repository : Europe PubMed Central
Language(s) : English

Predispensing of Antivirals to High-Risk Individuals in an Influenza Pandemic

Author(s) : Goldstein, Edward , Miller, Joel C. , O'Hagan, Justin , Lipsitch, Marc
Description : We consider the net benefits of predispensing antivirals to high-risk individuals during an influenza pandemic, where the measure of the benefit is the number of severe outcomes (such as deaths or hospitalizations) prevented by antivirals in the whole population. One potentia...
Repository : Europe PubMed Central
Language(s) : English

Weather-based prediction of Plasmodium falciparum malaria in epidemic-prone regions of Ethiopia I. Patterns of lagged weather effects reflect biological mechanisms

Author(s) : Teklehaimanot, Hailay D , Lipsitch, Marc , Teklehaimanot, Awash , Schwartz, Joel
Description :
Repository : Europe PubMed Central
Language(s) : English

Absolute Humidity and the Seasonal Onset of Influenza in the Continental US

Author(s) : Shaman, Jeffrey , Pitzer, Virginia , Viboud, Cecile , Lipsitch, Marc , Grenfell, Bryan
Description : Much of the observed wintertime increase of mortality in temperate regions is attributed to seasonal influenza. A recent re-analysis of laboratory experiments indicates that absolute humidity strongly modulates the airborne survival and transmission of the influenza virus. Here we extend these fin...
Repository : Europe PubMed Central
Language(s) : English

Shortcomings of Vitamin D-Based Model Simulations of Seasonal Influenza

Author(s) : Shaman, Jeffrey , Jeon, Christie Y. , Giovannucci, Edward , Lipsitch, Marc
Description : Seasonal variation in serum concentration of the vitamin D metabolite 25(OH) vitamin D [25(OH)D], which contributes to host immune function, has been hypothesized to be the underlying source of observed influenza seasonality in temperate re...
Repository : Europe PubMed Central
Language(s) : English

Pandemic Influenza: Risk of Multiple Introductions and the Need to Prepare for Them

Author(s) : Mills, Christina E , Robins, James M , Bergstrom, Carl T , Lipsitch, Marc
Description : Containing an emerging influenza H5N1 pandemic in its earliest stages may be feasible, but containing multiple introductions of a pandemic-capable strain would be more difficult. Mills and colleagues argue that multiple introductions are likely, especially if risk of a pandemic is high.
Repository : Europe PubMed Central
Language(s) : English

Alert Threshold Algorithms and Malaria Epidemic Detection

Author(s) : Teklehaimanot, Hailay Desta , Schwartz, Joel , Teklehaimanot, Awash , Lipsitch, Marc
Description : We describe a method for comparing the ability of different alert threshold algorithms to detect malaria epidemics and use it with a dataset consisting of weekly malaria cases collected from health facilities in 10 districts of Ethiopia from 1990 to 2000. Four types of alert threshold algorithms are...
Repository : Europe PubMed Central
Language(s) : English
<< < 3 4 5 6 7 > >>

Found 117 documents, displaying page 5 of 12