Results
author = "Lin, Dao-Hong"
K Depletion Enhances the Extracellular Ca2+-Induced Inhibition of the Apical K Channels in the Mtal of Rat Kidney
Author(s) :
Gu, Rui-Min
,
Wei, Yuan
,
Jiang, Ho-Lin
,
Lin, Dao-Hong
,
Sterling, Hyacinth
,
Bloom, Peter
,
Balazy, Micheal
,
Wang, Wen-Hui
Description :
We have shown previously that raising extracellular Ca2+ inhibited the apical 70-pS K channel in the thick ascending limb (TAL; Wang, W.H., M. Lu, and S.C. Hebert. 1996. Am. J. Physiol. 270:C103–C111). We now used the patch-clamp technique to study the effect of increasing the extracellular Ca2+ on ...
Repository :
Europe PubMed Central
Language(s) :
English
Inhibition of angiotensin type 1 receptor impairs renal ability of K conservation in response to K restriction
Description :
We have previously demonstrated that ANG II inhibits ROMK-like small-conductance K channels (SK) in the cortical collecting duct from rats on a K-deficient diet (KD) (35). In the present study, we examined the role of angiotensin type 1 receptor (AT1R) in mediating the effect of K restriction on K s...
Repository :
Europe PubMed Central
Language(s) :
English
MicroRNA 802 Stimulates ROMK Channels by Suppressing Caveolin-1
Description :
Dietary potassium stimulates the surface expression of ROMK channels in the aldosterone-sensitive distal nephron, but the mechanism by which this occurs is incompletely understood. Here, a high-potassium diet increased the transcription of microRNA (miR) 802 in the cortical collecting duct in mice. ...
Repository :
Europe PubMed Central
Language(s) :
English
ROMK1 channel activity is regulated by monoubiquitination
Author(s) :
Lin, Dao-Hong
,
Sterling, Hyacinth
,
Wang, Zhijian
,
Babilonia, Elisa
,
Yang, Baofeng
,
Dong, Ke
,
Hebert, Steven C.
,
Giebisch, Gerhard
Description :
The ubiquitination of proteins can signal their degradation, modify their activity or target them to specific membranes or cellular organelles. Here, we show that monoubiquitination regulates the plasma membrane abundance and function of the potassium channel, ROMK. Immunoprecipitation of proteins o...
Repository :
Europe PubMed Central
Language(s) :
English
Inhibition of MAPK stimulates the Ca2+-dependent big-conductance K channels in cortical collecting duct
Author(s) :
Li, Dimin
,
Wang, Zhijian
,
Sun, Peng
,
Jin, Yan
,
Lin, Dao-Hong
,
Hebert, Steven C.
,
Giebisch, Gerhard
,
Wang, Wen-Hui
Description :
The kidney plays a key role in maintaining potassium (K) homeostasis. K excretion is determined by the balance between K secretion and absorption in distal tubule segments such as the connecting tubule and cortical collecting duct. K secretion takes place by K entering principal cells (PC) from bloo...
Repository :
Europe PubMed Central
Language(s) :
English
Arachidonic Acid Inhibits Epithelial Na Channel Via Cytochrome P450 (CYP) Epoxygenase-dependent Metabolic Pathways
Author(s) :
Wei, Yuan
,
Lin, Dao-Hong
,
Kemp, Rowena
,
Yaddanapudi, Ganesh S.S.
,
Nasjletti, Alberto
,
Falck, John R.
,
Wang, Wen-Hui
Description :
We used the patch-clamp technique to study the effect of arachidonic acid (AA) on epithelial Na channels (ENaC) in the rat cortical collecting duct (CCD). Application of 10 μM AA decreased the ENaC activity defined by NPo from 1.0 to 0.1. The dose–response curve of the AA effect on ENaC shows that 2...
Repository :
Europe PubMed Central
Language(s) :
English
Epoxyeicosatrienoic Acid Activates BK Channels in the Cortical Collecting Duct
Author(s) :
Sun, Peng
,
Liu, Wen
,
Lin, Dao-Hong
,
Yue, Peng
,
Kemp, Rowena
,
Satlin, Lisa M.
,
Wang, Wen-Hui
Description :
The cortical collecting duct (CCD), which is involved in renal potassium (K) excretion, expresses cytochrome P450 (CYP)-epoxygenase. Here, we examined the effect of high dietary K on renal expression of CYP2C23 and CYP2J2 in the rat, as well as the role of CYP-epoxygenase–dependent metabolism of ara...
Repository :
Europe PubMed Central
Language(s) :
English
Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels
Author(s) :
Yue, Peng
,
Lin, Dao-Hong
,
Pan, Chun-Yang
,
Leng, Qiang
,
Giebisch, Gerhard
,
Lifton, Richard P.
,
Wang, Wen-Hui
Description :
WNK4 (with no lysine kinase 4) inhibits ROMK channel activity in the distal nephron by stimulating clathrin-dependent endocytosis, an effect attenuated by SGK1 (serum-glucocorticoids-induced kinase)-mediated phosphorylation. It has been suggested that increased ROMK activity because of SGK1-mediated...
Repository :
Europe PubMed Central
Language(s) :
English
POSH Stimulates the Ubiquitination and the Clathrin-independent Endocytosis of ROMK1 Channels*
Author(s) :
Lin, Dao-Hong
,
Yue, Peng
,
Pan, Chu-Yang
,
Sun, Peng
,
Zhang, Xin
,
Han, Zeguang
,
Roos, Marcel
,
Caplan, Michael
,
Giebisch, Gerhard
Description :
POSH (plenty of SH3) is a scaffold protein that has been shown to act as an E3 ubiquitin ligase. Here we report that POSH stimulates the ubiquitination of Kir1.1 (ROMK) and enhances the internalization of this potassium channel. Immunostaining reveals the expression of POSH in the renal cortical col...
Repository :
Europe PubMed Central
Language(s) :
English
Decrease in dietary K intake stimulates the generation of superoxide anions in the kidney and inhibits K secretory channels in the CCD
Author(s) :
Wang, Zhi-Jian
,
Sun, Peng
,
Xing, WenMing
,
Pan, ChunYang
,
Lin, Dao-Hong
,
Wang, Wen-Hui
Description :
We previously demonstrated that K depletion inhibited ROMK-like small-conductance K channels (SK) in the cortical collecting duct (CCD) and that the effect was mediated by superoxide anions that stimulated Src family protein tyrosine kinase (PTK) and mitogen-activated protein kinase (MAPK) (51). How...
Repository :
Europe PubMed Central
Language(s) :
English