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author = "Langie, Sabine A. S."
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Found 5 documents, displaying page 1 of 1

Adult-onset, short-term dietary restriction reduces cell senescence in mice

Author(s) : Wang, Chunfang , Maddick, Mandy , Miwa, Satomi , Jurk, Diana , Czapiewski, Rafal , Saretzki, Gabriele , Langie, Sabine A.S.
Description : Dietary restriction (DR) extends the lifespan of a wide variety of species and reduces the incidence of major age-related diseases. Cell senescence has been proposed as one causal mechanism for tissue and organism ageing. We show for the first time that adult-onset, short-term DR reduced frequencies...
Repository : Europe PubMed Central
Language(s) : English

An ECVAG trial on assessment of oxidative damage to DNA measured by the comet assay.

Author(s) : Johansson, Clara , Moller, Peter , Forchhammer, Lykke , Loft, Steffen , Godschalk, Roger W. L. , Langie, Sabine A. S.
Description : The increasing use of single cell gel electrophoresis (the comet assay) highlights its popularity as a method for detecting DNA damage, including the use of enzymes for assessment of oxidatively damaged DNA. However, comparison of DNA damage levels between laboratories can be difficult due to differ...
Repository : ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) : English

Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial.

Author(s) : Forchhammer, Lykke , Johansson, Clara , Loft, Steffen , Moller, Lennart , Godschalk, Roger W. L. , Langie, Sabine A. S.
Description : The comet assay has become a popular method for the assessment of DNA damage in biomonitoring studies and genetic toxicology. However, few studies have addressed the issue of the noted inter-laboratory variability of DNA damage measured by the comet assay. In this study, 12 laboratories analysed the...
Repository : ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) : English

An ECVAG† trial on assessment of oxidative damage to DNA measured by the comet assay

Author(s) : Johansson, Clara , Møller, Peter , Forchhammer, Lykke , Loft, Steffen , Godschalk, Roger W. L. , Langie, Sabine A. S.
Description : The increasing use of single cell gel electrophoresis (the comet assay) highlights its popularity as a method for detecting DNA damage, including the use of enzymes for assessment of oxidatively damaged DNA. However, comparison of DNA damage levels between laboratories can be difficult due to differ...
Repository : Europe PubMed Central
Language(s) : English

The role of glutathione in the regulation of nucleotide excision repair during oxidative stress.

Author(s) : Langie, Sabine A.S. , Knaapen, Ad M. , Houben, Joyce M.J. , van Kempen, Frederik C. , de Hoon, Joep P.J. , Gottschalk, Ralph W.H.
Description : Nucleotide excision repair (NER) mainly repairs bulky DNA adducts and helix distorting lesions, but is additionally considered to be a back-up system for base excision repair to remove oxidative stress induced DNA damage. Therefore, it can be speculated that NER is up-regulated or primed by oxidativ...
Repository : ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) : English
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Found 5 documents, displaying page 1 of 1