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author = "Lahl, Katharina"
1

Found 5 documents, displaying page 1 of 1

Control of immune responses towards self and non-self by Foxp3+ regulatory T cells Die Kontrolle von Immunantworten gegen Selbst und Fremd durch Foxp3+ regulatorische T Zellen

Author(s) : Lahl, Katharina
Description : The general role of regulatory T cells (Tregs) is to dampen unwanted immune responses towards certain antigens, mostly towards self. As a tool to investigate Foxp3+ Tregs, bacterial artificial chromosome (BAC) technology was chosen, allowing for monitoring and manipulation of Tregs directly in vivo ...
Repository : mediaTUM
Language(s) : English

DC activated via dectin-1 convert Treg into IL-17 producers

Author(s) : Osorio, Fabiola , LeibundGut-Landmann, Salomé , Lochner, Matthias , Lahl, Katharina , Sparwasser, Tim , Eberl, Gérard
Description : Th cells producing IL-17 play a pro-inflammatory role at mucosal surfaces. Treg at the same sites dampen inflammation and prevent immunopathology. Th cells producing IL-17 (Th17) and Treg are thought to be distinct populations defined by expression of the transcription factors ROR-γt and Foxp3, resp...
Repository : Europe PubMed Central
Language(s) : English

FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells

Author(s) : Schildknecht, Anita , Brauer, Sabine , Brenner, Corinne , Lahl, Katharina , Schild, Hansjörg , Sparwasser, Tim , Probst, Hans Christian
Description : Peripheral T-cell tolerance is thought to significantly contribute to the prevention of autoimmunity, and it has been shown that antigen-presenting steady-state dendritic cells efficiently induce peripheral tolerance. We previously showed that dendritic-cell–induced tolerance is a T-cell–intrinsic p...
Repository : Europe PubMed Central
Language(s) : English

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

Author(s) : Lahl, Katharina , Loddenkemper, Christoph , Drouin, Cathy , Freyer, Jennifer , Arnason, Jon , Eberl, Gérard , Hamann, Alf
Description : The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3–4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central cont...
Repository : Europe PubMed Central
Language(s) : English

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.

Author(s) : Lahl, Katharina , Loddenkemper, Christoph , Drouin, Cathy , Freyer, Jennifer , Arnason, Jon , Eberl, Gérard , Hamann, Alf
Description : The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3-4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central cont...
Repository : HAL - Hyper Article on Line
Language(s) : English
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Found 5 documents, displaying page 1 of 1