Results
author = "Kirsch-Volders, Micheline"
In vitro expression of hard metal dust (WC-Co)--responsive genes in human peripheral blood mononucleated cells.
Description :
Hard metals consist of tungsten carbide (WC) and metallic cobalt (Co) particles and are important industrial materials produced for their extreme hardness and high wear resistance properties. While occupational exposure to metallic Co alone is apparently not associated with an increased risk of canc...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Phenotyping for DNA repair capacity.
Description :
The ability to repair DNA damage is strongly associated with the risk of cancer and other human diseases as it is essential for maintenance of genome stability. Moreover, DNA repair capacity is an important factor contributing to the inter-individual variability in mutagen exposure, cancer developme...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Dose response and potential thresholds in proliferation and cell survival and death.
Description :
ECNIS is a Network of Excellence within the European Union’s Sixth Framework Programme, Priority
5: Food Quality and Safety. It brings together some of the best European research groups
in a concerted effort to achieve improved understanding of the environmental causes of cancer,
of the potential of...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
DNA repair enzyme genotypes and their toxicologically relevant phenotypes.
Description :
ECNIS is a Network of Excellence within the European Union’s Sixth Framework Programme,
Priority 5: Food Quality and Safety. It brings together some of the best European research groups
in a concerted effort to achieve improved understanding of the environmental causes of cancer, of the potential of...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables
Author(s) :
Holland, Nina
,
Fucic, Alexandra
,
Merlo, Domenico Franco
,
Sram, Radim
,
Kirsch-Volders, Micheline
Description :
Children may be more susceptible to the effects of the environmental exposure and medical treatments than adults; however, limited information is available about the differences in genotoxic effects in children by age, sex and health status. Micronucleus (MN) assay is a well established method of mo...
Repository :
Europe PubMed Central
Language(s) :
English
Validation of the nucleotide excision repair comet assay on cryopreserved PBMCs to measure inter-individual variation in DNA repair capacity.
Author(s) :
Allione, Alessandra
,
Russo, Alessia
,
Ricceri, Fulvio
,
Vande Loock, Kim
,
Guarrera, Simonetta
,
Voglino, Floriana
Description :
Inter-individual susceptibility to mutagens/carcinogens can be assessed by either genotyping DNA repair genes in different pathways or phenotyping DNA repair capacity (DRC) at the molecular or cellular level. Due to the large number of known DNA repair genes, and the interactions between repair path...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Synthesis and Characterization of Stable Monodisperse Silica Nanoparticle Sols for in Vitro Cytotoxicity Testing.
Author(s) :
Thomassen, Leen C J
,
Aerts, Alexander
,
Rabolli, Virginie
,
Lison, Dominique
,
Gonzalez, Laetitia
,
Kirsch-Volders, Micheline
Description :
For the investigation of the interaction of nanoparticles with biomolecules, cells, organs, and animal models there is a need for well-characterized nanoparticle suspensions. In this paper we report the preparation of monodisperse dense amorphous silica nanoparticles (SNP) suspended in physiological...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Sensitivity and specificity of techniques for the identification of biomarkers.
Author(s) :
Farmer, Peter B.
,
Phillips, David
,
Moller, Lennart
,
Singh, Raj
,
van Schooten, Frederik-Jan
,
Godschalk, Roger
,
Mateuca, Raluca
Description :
2.1. DNA adducts 2.2. Protein adducts 2.3. Chromosomal damage
,
The approaches described for the determination of DNA adducts mostly reach
sensitivity limits in the range of 1 adduct/107–109 nucleotides and are thus applicable for studies of environmental exposure to genotoxins. Availability of DNA may...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Challenges from new technologies and new biomarkers.
Author(s) :
Vineis, Paolo
,
Vermeulen, Roel
,
Geneletti, Sara
,
Minelli, Cosetta
,
Taioli, Emanuela
,
Thompson, John
,
Stromberg, Ulf
Description :
ECNIS is a Network of Excellence within the European Union’s Sixth Framework Programme, Priority 5: Food Quality and Safety. It brings together some of the best European research groups in a concerted effort to achieve improved understanding of the environmental causes of cancer, of the potential of...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
State of validation of biomarkers of carcinogen exposure and effect. Generic biomarkers.
Author(s) :
Phillips, David H.
,
Venitt, Stan
,
Jonsson, Bo A.G.
,
Farmer, Peter
,
Mateuca, Raluca
,
Kirsch-Volders, Micheline
,
Loft, Steffen
Description :
ECNIS is a Network of Excellence within the European Union Sixth Framework Programme, Priority 5: Food Quality and Safety. It brings together some of the best European research groups in a concerted effort to achieve improved understanding of the environmental causes of cancer, of the potential of d...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English