Results
author = "Kayser, Manfred"
Evaluating Self-declared Ancestry of U.S. Americans with Autosomal, Y-chromosomal and Mitochondrial DNA
Author(s) :
Lao, Oscar
,
Vallone, Peter M
,
Coble, Michael D
,
Diegoli, Toni M
,
van Oven, Mannis
,
van der Gaag, Kristiaan J
,
Pijpe, Jeroen
Description :
The current U.S. population represents an amalgam of individuals originating mainly from four continental regions (Africa, Europe, Asia and America). To study the genetic ancestry and compare with self-declared ancestry we have analyzed paternally, maternally and bi-parentally inherited DNA markers ...
Repository :
Europe PubMed Central
Language(s) :
English
Model-based prediction of human hair color using DNA variants
Author(s) :
Branicki, Wojciech
,
Liu, Fan
,
van Duijn, Kate
,
Draus-Barini, Jolanta
,
Pośpiech, Ewelina
,
Walsh, Susan
,
Kupiec, Tomasz
Description :
Predicting complex human phenotypes from genotypes is the central concept of widely advocated personalized medicine, but so far has rarely led to high accuracies limiting practical applications. One notable exception, although less relevant for medical but important for forensic purposes, is human e...
Repository :
Europe PubMed Central
Language(s) :
English
Postnatal parental smoking: an important risk factor for SIDS
Author(s) :
Liebrechts-Akkerman, Germaine
,
Lao, Oscar
,
Liu, Fan
,
van Sleuwen, Bregje E.
,
Engelberts, Adèle C.
,
L’Hoir, Monique P.
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Detecting Low Frequent Loss-of-Function Alleles in Genome Wide Association Studies with Red Hair Color as Example
Author(s) :
Liu, Fan
,
Struchalin, Maksim V.
,
van Duijn, Kate
,
Hofman, Albert
,
Uitterlinden, André G.
,
van Duijn, Cornelia
,
Aulchenko, Yurii S.
Description :
Multiple loss-of-function (LOF) alleles at the same gene may influence a phenotype not only in the homozygote state when alleles are considered individually, but also in the compound heterozygote (CH) state. Such LOF alleles typically have low frequencies and moderate to large effects. Detecting suc...
Repository :
Europe PubMed Central
Language(s) :
English
Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing
Author(s) :
de Gruijter, Johanna Maria
,
Lao, Oscar
,
Vermeulen, Mark
,
Xue, Yali
,
Woodwark, Cara
,
Gillson, Christopher J
,
Coffey, Alison J
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Reduced Y-Chromosome, but Not Mitochondrial DNA, Diversity in Human Populations from West New Guinea
Author(s) :
Kayser, Manfred
,
Brauer, Silke
,
Weiss, Gunter
,
Schiefenhövel, Wulf
,
Underhill, Peter
,
Shen, Peidong
,
Oefner, Peter
Description :
To investigate the paternal population history of New Guinea, 183 individuals from 11 regional populations of West New Guinea (WNG) and 131 individuals from Papua New Guinea (PNG) were analyzed at 26 binary markers and seven short-tandem-repeat loci from the nonrecombining part of the human Y chromo...
Repository :
Europe PubMed Central
Language(s) :
English
Predicting human height by Victorian and genomic methods
Author(s) :
Aulchenko, Yurii S
,
Struchalin, Maksim V
,
Belonogova, Nadezhda M
,
Axenovich, Tatiana I
,
Weedon, Michael N
,
Hofman, Albert
Description :
In the Victorian era, Sir Francis Galton showed that ‘when dealing with the transmission of stature from parents to children, the average height of the two parents, … is all we need care to know about them' (1886). One hundred and twenty-two years after Galton's work was published, 54 loci showing s...
Repository :
Europe PubMed Central
Language(s) :
English
The Effective Mutation Rate at Y Chromosome Short Tandem Repeats, with Application to Human Population-Divergence Time
Author(s) :
Zhivotovsky, Lev A.
,
Underhill, Peter A.
,
Cinnioğlu, Cengiz
,
Kayser, Manfred
,
Morar, Bharti
,
Kivisild, Toomas
,
Scozzari, Rosaria
Description :
We estimate an effective mutation rate at an average Y chromosome short-tandem repeat locus as 6.9×10-4 per 25 years, with a standard deviation across loci of 5.7×10-4, using data on microsatellite variation within Y chromosome haplogroups defined by unique-event polymorphisms in populations with do...
Repository :
Europe PubMed Central
Language(s) :
English
A Comprehensive Survey of Human Y-Chromosomal Microsatellites
Author(s) :
Kayser, Manfred
,
Kittler, Ralf
,
Erler, Axel
,
Hedman, Minttu
,
Lee, Andrew C.
,
Mohyuddin, Aisha
,
Mehdi, S. Qasim
Description :
We have screened the nearly complete DNA sequence of the human Y chromosome for microsatellites (short tandem repeats) that meet the criteria of having a repeat-unit size of ⩾3 and a repeat count of ⩾8 and thus are likely to be easy to genotype accurately and to be polymorphic. Candidate loci were t...
Repository :
Europe PubMed Central
Language(s) :
English
Comprehensive mutation analysis of 17 Y-chromosomal short tandem repeat polymorphisms included in the AmpFlSTR® Yfiler® PCR amplification kit
Author(s) :
Goedbloed, Miriam
,
Vermeulen, Mark
,
Fang, Rixun N.
,
Lembring, Maria
,
Wollstein, Andreas
,
Ballantyne, Kaye
,
Lao, Oscar
Description :
The Y-chromosomal short tandem repeat (Y-STR) polymorphisms included in the AmpFlSTR® Yfiler® polymerase chain reaction amplification kit have become widely used for forensic and evolutionary applications where a reliable knowledge on mutation properties is necessary for correct data interpretation....
Repository :
Europe PubMed Central
Language(s) :
English