Results
author = "Kaibuchi, Kozo"
Role of Numb in Dendritic Spine Development with a Cdc42 GEF Intersectin and EphB2D⃞
Author(s) :
Nishimura, Takashi
,
Yamaguchi, Tomoya
,
Tokunaga, Akinori
,
Hara, Akitoshi
,
Hamaguchi, Tomonari
,
Kato, Katsuhiro
Description :
Numb has been implicated in cortical neurogenesis during nervous system development, as a result of its asymmetric partitioning and antagonizing Notch signaling. Recent studies have revealed that Numb functions in clathrin-dependent endocytosis by binding to the AP-2 complex. Numb is also expressed ...
Repository :
Europe PubMed Central
Language(s) :
English
EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells
Author(s) :
Li, Wenjing
,
Miki, Tomohiro
,
Watanabe, Takashi
,
Kakeno, Mai
,
Sugiyama, Ikuko
,
Kaibuchi, Kozo
,
Goshima, Gohta
Description :
The microtubule plus end regulator EB1 brings Sentin and possibly a microtubule polymerase to microtubule plus ends to promote microtubule dynamics.
Repository :
Europe PubMed Central
Language(s) :
English
S100P Is a Novel Interaction Partner and Regulator of IQGAP1*
Author(s) :
Heil, Annika
,
Nazmi, Ali Reza
,
Koltzscher, Max
,
Poeter, Michaela
,
Austermann, Judith
,
Assard, Nicole
,
Baudier, Jacques
Description :
Ca2+-binding proteins of the S100 family participate in intracellular Ca2+ signaling by binding to and regulating specific cellular targets in their Ca2+-loaded conformation. Because the information on specific cellular targets of different S100 proteins is still limited, we developed an affinity ap...
Repository :
Europe PubMed Central
Language(s) :
English
Positive Role of IQGAP1, an Effector of Rac1, in Actin-Meshwork Formation at Sites of Cell-Cell ContactD⃞V⃞
Author(s) :
Noritake, Jun
,
Fukata, Masaki
,
Sato, Kazumasa
,
Nakagawa, Masato
,
Watanabe, Takashi
,
Izumi, Nanae
,
Wang, Shujie
,
Fukata, Yuko
Description :
The small guanosine triphosphatase Rac1 is activated by E-cadherin-mediated cell-cell adhesion and is required for the accumulation of actin filaments, E-cadherin, and β-catenin at sites of cell-cell contact. However, the modes of activation and action of Rac1 remain to be clarified. We here found t...
Repository :
Europe PubMed Central
Language(s) :
English
Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition
Author(s) :
Mishima, Masaki
,
Maesaki, Ryoko
,
Kasa, Miyuki
,
Watanabe, Takashi
,
Fukata, Masaki
,
Kaibuchi, Kozo
,
Hakoshima, Toshio
Description :
Cytoplasmic linker protein 170 (CLIP-170) is a prototype of the plus end-tracking proteins that regulate microtubule dynamics, but it is obscure how CLIP-170 recognizes the microtubule plus end and contributes to polymerization rescue. Crystallographic, NMR, and mutation studies of two tandem cytosk...
Repository :
Europe PubMed Central
Language(s) :
English
Roles of Rho-associated Kinase in Cytokinesis; Mutations in Rho-associated Kinase Phosphorylation Sites Impair Cytokinetic Segregation of Glial Filaments
Author(s) :
Yasui, Yoshihiro
,
Amano, Mutsuki
,
Nagata, Koh-ichi
,
Inagaki, Naoyuki
,
Nakamura, Hideo
,
Saya, Hideyuki
,
Kaibuchi, Kozo
Description :
Rho-associated kinase (Rho-kinase), which is activated by the small GTPase Rho, regulates formation of stress fibers and focal adhesions, myosin fiber organization, and neurite retraction through the phosphorylation of cytoskeletal proteins, including myosin light chain, the ERM family proteins (...
Repository :
Europe PubMed Central
Language(s) :
English
Phosphorylation of Adducin by Rho-Kinase Plays a Crucial Role in Cell Motility
Author(s) :
Fukata, Yuko
,
Oshiro, Noriko
,
Kinoshita, Nagatoki
,
Kawano, Yoji
,
Matsuoka, Yoichiro
,
Bennett, Vann
,
Matsuura, Yoshiharu
Description :
Adducin is a membrane skeletal protein that binds to actin filaments (F-actin) and thereby promotes the association of spectrin with F-actin to form a spectrin-actin meshwork beneath plasma membranes such as ruffling membranes. Rho-associated kinase (Rho- kinase), which is activated by the small ...
Repository :
Europe PubMed Central
Language(s) :
English
Phosphorylation of Myosin-Binding Subunit (Mbs) of Myosin Phosphatase by Rho-Kinase in Vivo
Author(s) :
Kawano, Yoji
,
Fukata, Yuko
,
Oshiro, Noriko
,
Amano, Mutsuki
,
Nakamura, Toshikazu
,
Ito, Masaaki
,
Matsumura, Fumio
,
Inagaki, Masaki
Description :
Rho-associated kinase (Rho-kinase), which is activated by the small GTPase Rho, phosphorylates myosin-binding subunit (MBS) of myosin phosphatase and thereby inactivates the phosphatase activity in vitro. Rho-kinase is thought to regulate the phosphorylation state of the substrates including myosin ...
Repository :
Europe PubMed Central
Language(s) :
English
Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF
Author(s) :
Taya, Shinichiro
,
Inagaki, Naoyuki
,
Sengiku, Hiroaki
,
Makino, Hiroshi
,
Iwamatsu, Akihiro
,
Urakawa, Itaru
,
Nagao, Kenji
Description :
Insulin-like growth factor (IGF)-1 plays crucial roles in growth control and rearrangements of the cytoskeleton. IGF-1 binds to the IGF-1 receptor and thereby induces the autophosphorylation of this receptor at its tyrosine residues. The phosphorylation of the IGF-1 receptor is thought to initiate a...
Repository :
Europe PubMed Central
Language(s) :
English
Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association
Author(s) :
Matsui, Takeshi
,
Maeda, Masato
,
Doi, Yoshinori
,
Yonemura, Shigenobu
,
Amano, Mutsuki
,
Kaibuchi, Kozo
,
Tsukita, Sachiko
Description :
The ezrin/radixin/moesin (ERM) proteins are involved in actin filament/plasma membrane interaction that is regulated by Rho. We examined whether ERM proteins are directly phosphorylated by Rho- associated kinase (Rho-kinase), a direct target of Rho. Recombinant full-length and COOH-terminal half ...
Repository :
Europe PubMed Central
Language(s) :
English