Results
author = "Kagnoff, Martin F."
Celiac disease: pathogenesis of a model immunogenetic disease
Author(s) :
Kagnoff, Martin F.
Description :
Celiac disease is characterized by small-intestinal mucosal injury and nutrient malabsorption in genetically susceptible individuals in response to the dietary ingestion of wheat gluten and similar proteins in barley and rye. Disease pathogenesis involves interactions among environmental, genetic, a...
Repository :
Europe PubMed Central
Language(s) :
English
Gastrointestinal Manifestations of the Acquired Immunodeficiency Syndrome
Description :
In addition to abnormalities in systemic immune function, patients with the acquired immunodeficiency syndrome (AIDS) and the pre-AIDS syndromes have significant abnormalities in the distribution of T-cell subsets in the intestinal tract. Such immune deficits predispose such patients to opportunisti...
Repository :
Europe PubMed Central
Language(s) :
English
FUNCTIONAL CHARACTERISTICS OF PEYER'S PATCH LYMPHOID CELLS : I. INDUCTION OF HUMORAL ANTIBODY AND CELL-MEDIATED ALLOGRAFT REACTIONS
Description :
Peyer's patches from normal mice contain antigen-sensitive B and T cells, but lack the accessory adherent cell type(s) required both for the induction of humoral immune responses and for the induction of allograft reactions against cell surface alloantigens. Immune responsiveness can be restored to...
Repository :
Europe PubMed Central
Language(s) :
English
Nod1 Is an Essential Signal Transducer in Intestinal Epithelial Cells Infected with Bacteria That Avoid Recognition by Toll-Like Receptors
Description :
The transcription factor NF-κB in human intestinal epithelial cells plays a central role in regulating genes that govern the onset of mucosal inflammatory responses following intestinal microbial infection. Nod1 is a cytosolic pattern recognition receptor in mammalian cells that senses components of...
Repository :
Europe PubMed Central
Language(s) :
English
FUNCTIONAL CHARACTERISTICS OF PEYER'S PATCH LYMPHOID CELLS : II. LIPOPOLYSACCHARIDE IS THYMUS DEPENDENT
Description :
This study shows that LPS is not mitogenic in cultures containing B cells, or B cells and accessory adherent cells or ME, unless T cells are present. This observation rules out models of induction of antibody synthesis in which it is assumed that the delivery of a mitogenic signal by the interactio...
Repository :
Europe PubMed Central
Language(s) :
English
Intestinal Epithelial Cell Apoptosis following Cryptosporidium parvum Infection
Description :
Cryptosporidium parvum induces moderate levels of apoptosis of cultured human intestinal epithelial cells, which are maximal at 24 h after infection. Apoptosis is further increased in C. parvum-infected cells by inhibition of NF-κB. C. parvum infection also attenuates epithelial apoptosis induced by...
Repository :
Europe PubMed Central
Language(s) :
English
Human Intestinal Epithelial Cells Respond to Cryptosporidium parvum Infection with Increased Prostaglandin H Synthase 2 Expression and Prostaglandin E2 and F2α Production
Author(s) :
Laurent, Fabrice
,
Kagnoff, Martin F.
,
Savidge, Tor C.
,
Naciri, Muriel
,
Eckmann, Lars
Description :
Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. Here, we show that C. ...
Repository :
Europe PubMed Central
Language(s) :
English
Cell Differentiation Is a Key Determinant of Cathelicidin LL-37/Human Cationic Antimicrobial Protein 18 Expression by Human Colon Epithelium
Description :
Antimicrobial peptides are highly conserved evolutionarily and are thought to play an important role in innate immunity at intestinal mucosal surfaces. To better understand the role of the antimicrobial peptide human cathelicidin LL-37/human cationic antimicrobial protein 18 (hCAP18) in intestinal m...
Repository :
Europe PubMed Central
Language(s) :
English
Central Importance of Immunoglobulin A in Host Defense against Giardia spp.
Author(s) :
Langford, T. Dianne
,
Housley, Michael P.
,
Boes, Marianne
,
Chen, Jianzhu
,
Kagnoff, Martin F.
,
Gillin, Frances D.
Description :
The protozoan pathogen Giardia is an important cause of parasitic diarrheal disease worldwide. It colonizes the lumen of the small intestine, suggesting that effective host defenses must act luminally. Immunoglobulin A (IgA) antibodies are presumed to be important for controlling Giardia infection, ...
Repository :
Europe PubMed Central
Language(s) :
English
IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium
Author(s) :
Egan, Laurence J.
,
Eckmann, Lars
,
Greten, Florian R.
,
Chae, Sungwon
,
Li, Zhi-Wei
,
Myhre, Gennett M.
,
Robine, Sylvie
Description :
Acute injury to the intestinal mucosa is a major dose-limiting complication of abdominal radiation therapy. We studied the role of the transcription factor NF-κB in protection against radiation-induced apoptosis in the intestinal epithelium in vivo. We use mice in which NF-κB signaling through IκB-k...
Repository :
Europe PubMed Central
Language(s) :
English