Results
author = "Jonjic, Stipan"
Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus‡
Author(s) :
Bubić, Ivan
,
Wagner, Markus
,
Krmpotić, Astrid
,
Saulig, Tanja
,
Kim, Sungjin
,
Yokoyama, Wayne M.
,
Jonjić, Stipan
,
Koszinowski, Ulrich H.
Description :
Mouse strains are either resistant or susceptible to murine cytomegalovirus (MCMV). Resistance is determined by the Cmv1r (Ly49h) gene, which encodes the Ly49H NK cell activation receptor. The protein encoded by the m157 gene of MCMV has been defined as a ligand for Ly49H. To find out whether the m1...
Repository :
Europe PubMed Central
Language(s) :
English
A cytomegaloviral protein reveals a dual role for STAT2 in IFN-γ signaling and antiviral responses
Author(s) :
Zimmermann, Albert
,
Trilling, Mirko
,
Wagner, Markus
,
Wilborn, Manuel
,
Bubic, Ivan
,
Jonjic, Stipan
,
Koszinowski, Ulrich
Description :
A mouse cytomegalovirus (MCMV) gene conferring interferon (IFN) resistance was identified. This gene, M27, encodes a 79-kD protein that selectively binds and down-regulates for signal transducer and activator of transcription (STAT)-2, but it has no effect on STAT1 activation and signaling. The abse...
Repository :
Europe PubMed Central
Language(s) :
English
Targeted Deletion of Regions Rich in Immune-Evasive Genes from the Cytomegalovirus Genome as a Novel Vaccine Strategy▿
Author(s) :
Čičin-Šain, Luka
,
Bubić, Ivan
,
Schnee, Margit
,
Ruzsics, Zsolt
,
Mohr, Christian
,
Jonjić, Stipan
,
Koszinowski, Ulrich H.
Description :
Human cytomegalovirus (CMV), a ubiquitous human pathogen, is a leading cause of congenital infections and represents a serious health risk for the immunosuppressed patient. A vaccine against CMV is currently not available. CMV is characterized by its large genome and by multiple genes modulating the...
Repository :
Europe PubMed Central
Language(s) :
English
The Immunoevasive Function Encoded by the Mouse Cytomegalovirus Gene m152 Protects the Virus against T Cell Control in Vivo
Author(s) :
Krmpotic, Astrid
,
Messerle, Martin
,
Crnkovic-Mertens, Irena
,
Polic, Bojan
,
Jonjic, Stipan
,
Koszinowski, Ulrich H.
Description :
Cytomegaloviruses encode numerous functions that inhibit antigen presentation in the major histocompatibility complex (MHC) class I pathway in vitro. One example is the mouse cytomegalovirus (MCMV) glycoprotein gp40, encoded by the m152 gene, which selectively retains murine but not human MHC class ...
Repository :
Europe PubMed Central
Language(s) :
English
Hierarchical and Redundant Lymphocyte Subset Control Precludes Cytomegalovirus Replication during Latent Infection
Author(s) :
Polić, Bojan
,
Hengel, Hartmut
,
Krmpotić, Astrid
,
Trgovcich, Joanne
,
Pavić, Ivica
,
Lučin, Pero
,
Jonjić, Stipan
,
Koszinowski, Ulrich H.
Description :
Reactivation from latent cytomegalovirus (CMV) infection is often associated with conditions of immunosuppression and can result in fatal disease. Whether the maintenance of systemic CMV latency is mainly governed by factors of the infected cell or by immune control functions is unknown. Likewise...
Repository :
Europe PubMed Central
Language(s) :
English
Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89
Author(s) :
Del Val, Margarita
,
Volkmer, Hansjürgen
,
Rothbard, Jonathan B.
,
Jonjic, Stipan
,
Messerle, Martin
,
Schickedanz, Jörg
Description :
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells. Protection of BALB/c (H-2d) mice against a lethal murine cytomegalov...
Repository :
Open Access LMU
Language(s) :
Undetermined
Dominant-Negative FADD Rescues the In Vivo Fitness of a Cytomegalovirus Lacking an Antiapoptotic Viral Gene▿
Author(s) :
Čičin-Šain, Luka
,
Ruzsics, Zsolt
,
Podlech, Juergen
,
Bubić, Ivan
,
Menard, Carine
,
Jonjić, Stipan
,
Reddehase, Matthias J.
Description :
Genes that inhibit apoptosis have been described for many DNA viruses. Herpesviruses often contain even more than one gene to control cell death. Apoptosis inhibition by viral genes is postulated to contribute to viral fitness, although a formal proof is pending. To address this question, we studied...
Repository :
Europe PubMed Central
Language(s) :
English
Selective Down-Regulation of the NKG2D Ligand H60 by Mouse Cytomegalovirus m155 Glycoprotein
Author(s) :
Hasan, Milena
,
Krmpotic, Astrid
,
Ruzsics, Zsolt
,
Bubic, Ivan
,
Lenac, Tihana
,
Halenius, Anne
,
Loewendorf, Andrea
,
Messerle, Martin
Description :
Both human and mouse cytomegaloviruses (CMVs) encode proteins that inhibit the activation of NK cells by down-regulating cellular ligands for the activating NK cell receptor NKG2D. Up to now, three ligands for the NKG2D receptor, named RAE-1, H60, and MULT-1, have been identified in mice. The resist...
Repository :
Europe PubMed Central
Language(s) :
English
Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus▿
Author(s) :
Arapović, Jurica
,
Lenac, Tihana
,
Antulov, Ronald
,
Polić, Bojan
,
Ruzsics, Zsolt
,
Carayannopoulos, Leonidas N.
,
Koszinowski, Ulrich H.
Description :
The NKG2D receptor is one of the most potent activating natural killer cell receptors involved in antiviral responses. The mouse NKG2D ligands MULT-1, RAE-1, and H60 are regulated by murine cytomegalovirus (MCMV) proteins m145, m152, and m155, respectively. In addition, the m138 protein interferes w...
Repository :
Europe PubMed Central
Language(s) :
English
Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
Author(s) :
Babić, Marina
,
Pyzik, Michal
,
Zafirova, Biljana
,
Mitrović, Maja
,
Butorac, Višnja
,
Lanier, Lewis L.
,
Krmpotić, Astrid
Description :
Natural killer cell recognition of “missing self” contributes meaningfully to control of mouse cytomegalovirus infection in vivo.
Repository :
Europe PubMed Central
Language(s) :
English