Results
author = "Jonjic, Stipan"
Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes
Author(s) :
Saalmüller, Armin
,
Reddehase, Matthias J.
,
Bühring, Hans-Jörg
,
Jonjic, Stipan
,
Koszinowski, Ulrich H.
Description :
The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4+CD8- T lymphocytes, respectively, two unusual ...
Repository :
Open Access LMU
Language(s) :
Undetermined
II. Detection of an antigen on resting T cells down-regulated after activation
Author(s) :
Saalmüller, Armin
,
Jonjic, Stipan
,
Bühring, Hans-Jörg
,
Reddehase, Matthias J.
,
Koszinowski, Ulrich H.
Description :
The expression of an antigen on porcine T lymphocytes detected by murine monoclonal antibody (mAb) 8/1 was investigated by functional studies and dual-parameter immunofluorescence. mAb 8/1 reacts with greater than 95% of thymocytes and in peripheral blood with all T lymphocytes and with cells of the...
Repository :
Open Access LMU
Language(s) :
English
Stable expression of clonal specificity in murine cytomegalovirus-specific large granular lymphoblast lines propagated long-term in recombinant interleukin 2.
Author(s) :
Reddehase, Matthias J.
,
Zawatzky, R.
,
Weiland, Frank
,
Bühring, Hans-Jörg
,
Jonjic, Stipan
,
Koszinowski, Ulrich H.
Description :
Repository :
Open Access LMU
Language(s) :
English
Distribution of T-lymphocyte subsets in porcine lymphoid tissues
Author(s) :
Saalmüller, Armin
,
Jonjic, Stipan
,
Bühring, Hans-Jörg
,
Reddehase, Matthias J.
,
Koszinowski, Ulrich H.
Description :
The distribution of the functional subsets of porcine T cells, the cytolytic/suppressor (Tc/s) and the helper/inducer (Th/i) cells was studied in cryostat sections of thymus, lymph nodes, tonsils, Peyer's patches, spleen and liver using the indirect immunoperoxidase technique. Three murine monoclona...
Repository :
Open Access LMU
Language(s) :
Undetermined
Altered development of the brain after focal herpesvirus infection of the central nervous system
Author(s) :
Koontz, Thad
,
Bralic, Marina
,
Tomac, Jelena
,
Pernjak-Pugel, Ester
,
Bantug, Glen
,
Jonjic, Stipan
,
Britt, William J.
Description :
Human cytomegalovirus infection of the developing central nervous system (CNS) is a major cause of neurological damage in newborn infants and children. To investigate the pathogenesis of this human infection, we developed a mouse model of infection in the developing CNS. Intraperitoneal inoculation ...
Repository :
Europe PubMed Central
Language(s) :
English
Virus Attenuation after Deletion of the Cytomegalovirus Fc Receptor Gene Is Not due to Antibody Control
Author(s) :
Crnković-Mertens, Irena
,
Messerle, Martin
,
Milotić, Irena
,
Szepan, Uwe
,
Kučić, Natalija
,
Krmpotić, Astrid
,
Jonjić, Stipan
Description :
The murine cytomegalovirus (MCMV) fcr-1 gene codes for a glycoprotein located at the surface of infected cells which strongly binds the Fc fragment of murine immunoglobulin G. To determine the biological significance of the fcr-1 gene during viral infection, we constructed MCMV fcr-1 deletion mutant...
Repository :
Europe PubMed Central
Language(s) :
English
Comparison between Human Cytomegalovirus pUL97 and Murine Cytomegalovirus (MCMV) pM97 Expressed by MCMV and Vaccinia Virus: pM97 Does Not Confer Ganciclovir Sensitivity
Author(s) :
Wagner, Markus
,
Michel, Detlef
,
Schaarschmidt, Peter
,
Vaida, Bianca
,
Jonjic, Stipan
,
Messerle, Martin
,
Mertens, Thomas
Description :
The UL97 protein (pUL97) of human cytomegalovirus (HCMV) is a protein kinase that also phosphorylates ganciclovir (GCV), but its biological function is not yet clear. The M97 protein (pM97) of mouse cytomegalovirus (MCMV) is the homolog of pUL97. First, we studied the consequences of genetic replace...
Repository :
Europe PubMed Central
Language(s) :
English
Distinct MHC class I–dependent NK cell–activating receptors control cytomegalovirus infection in different mouse strains
Author(s) :
Pyzik, Michał
,
Charbonneau, Benoit
,
Gendron-Pontbriand, Eve-Marie
,
Babić, Marina
,
Krmpotić, Astrid
,
Jonjić, Stipan
Description :
MCMV-infected cells are recognized by multiple MHC class I–restricted Ly49-activating receptors in genetically distinct mouse strains.
Repository :
Europe PubMed Central
Language(s) :
English
Virus Progeny of Murine Cytomegalovirus Bacterial Artificial Chromosome pSM3fr Show Reduced Growth in Salivary Glands due to a Fixed Mutation of MCK-2 ▿
Author(s) :
Jordan, Stefan
,
Krause, Johannes
,
Prager, Adrian
,
Mitrovic, Maja
,
Jonjic, Stipan
,
Koszinowski, Ulrich H.
,
Adler, Barbara
Description :
Murine cytomegalovirus (MCMV) Smith strain has been cloned as a bacterial artificial chromosome (BAC) named pSM3fr and used for analysis of virus gene functions in vitro and in vivo. When sequencing the complete BAC genome, we identified a frameshift mutation within the open reading frame (ORF) enco...
Repository :
Europe PubMed Central
Language(s) :
English
Glucocortiocoid Treatment of MCMV Infected Newborn Mice Attenuates CNS Inflammation and Limits Deficits in Cerebellar Development
Author(s) :
Kosmac, Kate
,
Bantug, Glenn R.
,
Pugel, Ester P.
,
Cekinovic, Djurdjica
,
Jonjic, Stipan
,
Britt, William J.
Description :
Infection of the developing fetus with human cytomegalovirus (HCMV) is a major cause of central nervous system disease in infants and children; however, mechanism(s) of disease associated with this intrauterine infection remain poorly understood. Utilizing a mouse model of HCMV infection of the deve...
Repository :
Europe PubMed Central
Language(s) :
English