Results
author = "Jonjic, Stipan"
CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors
Author(s) :
Reddehase, Matthias J.
,
Jonjic, Stipan
,
Weiland, Frank
,
Mutter, Wolfgang
,
Koszinowski, Ulrich H.
Description :
The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments. At a stage of pathogenesis when virus had already colonized target tissues, a therapeutic antiviral function c...
Repository :
Open Access LMU
Language(s) :
English
Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor
Author(s) :
Lucin, Pero
,
Jonjic, Stipan
,
Messerle, Martin
,
Polic, Bojan
,
Hengel, Hartmut
,
Koszinowski, Ulrich H.
Description :
We have shown previously that the antiviral function of CD4+ T lymphocytes against murine cytomegalovirus (MCMV) is associated with the release of interferon- (IFN-). We now demonstrate that IFN- and tumour necrosis factor alpha (TNF-) display synergism in their antiviral activity. As little as 2 ng...
Repository :
Open Access LMU
Language(s) :
Undetermined
Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection
Author(s) :
Pavic, Ivica
,
Polic, Bojan
,
Crnkovic, Irena
,
Lucin, Pero
,
Jonjic, Stipan
,
Koszinowski, Ulrich H.
Description :
Interferon gamma (IFN) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission. Because IFN cannot be responsible for all cytokine effects during recovery from MCMV infection we have now tested the potent...
Repository :
Open Access LMU
Language(s) :
Undetermined
Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143
Author(s) :
Budt, Matthias
,
Niederstadt, Lars
,
Valchanova, Ralitsa S.
,
Jonjic, Stipan
,
Brune, Wolfram
Description :
Double-stranded RNA (dsRNA) produced during viral infection activates several cellular antiviral responses. Among the best characterized is the shutoff of protein synthesis mediated by the dsRNA-dependent protein kinase (PKR) and the oligoadenylate synthetase (OAS)/RNase L system. As viral replicati...
Repository :
Publikationsserver des Robert Koch-Instituts
Language(s) :
German
Vaccination of Mice with Bacteria Carrying a Cloned Herpesvirus Genome Reconstituted In Vivo
Author(s) :
Cicin-Sain, Luka
,
Brune, Wolfram
,
Bubic, Ivan
,
Jonjic, Stipan
,
Koszinowski, Ulrich H.
Description :
Bacterial delivery systems are gaining increasing interest as potential vaccination vectors to deliver either proteins or nucleic acids for gene expression in the recipient. Bacterial delivery systems for gene expression in vivo usually contain small multicopy plasmids. We have shown before that bac...
Repository :
Europe PubMed Central
Language(s) :
English
Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143▿
Author(s) :
Budt, Matthias
,
Niederstadt, Lars
,
Valchanova , Ralitsa S.
,
Jonjić, Stipan
,
Brune, Wolfram
Description :
Double-stranded RNA (dsRNA) produced during viral infection activates several cellular antiviral responses. Among the best characterized is the shutoff of protein synthesis mediated by the dsRNA-dependent protein kinase (PKR) and the oligoadenylate synthetase (OAS)/RNase L system. As viral replicati...
Repository :
Europe PubMed Central
Language(s) :
English
A Gammaherpesvirus Complement Regulatory Protein Promotes Initiation of Infection by Activation of Protein Kinase Akt/PKB
Description :
Repository :
Europe PubMed Central
Language(s) :
English
The Conditions of Primary Infection Define the Load of Latent Viral Genome in Organs and the Risk of Recurrent Cytomegalovirus Disease
Author(s) :
Reddehase, Matthias J.
,
Balthesen, Monika
,
Rapp, Maria
,
Jonjic, Stipan
,
Pavic, Ivica
,
Koszinowski, Ulrich H.
Description :
Recurrence of cytomegalovirus (CMV) from latency is a frequent cause of disease in immunocompromised
patients. To date, there is no explanation for the diversity in the clinical manifestations.
Primary infection can occur perinatally or later in life, and inevitably results in latent infection.
Sero...
Repository :
Open Access LMU
Language(s) :
Undetermined
A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection
Author(s) :
Jonjic, Stipan
,
Del Val, Margarita
,
Keil, Günther M.
,
Reddehase, Matthias J.
,
Koszinowski, Ulrich H.
Description :
The nonstructural immediate-early protein pp89 of murine cytomegalovirus (MCMV) is the first viral protein synthesized after infection and has a regulatory function in viral gene expression. Despite its localization in the nucleus of infected cells, pp89 is also the dominant antigen recognized by MC...
Repository :
Open Access LMU
Language(s) :
Undetermined
Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs
Author(s) :
Reddehase, Matthias J.
,
Weiland, Frank
,
Münch, Konrad
,
Jonjic, Stipan
,
Lüske, Anke
,
Koszinowski, Ulrich H.
Description :
Interstitial pneumonia associated with viral replication in lung tissue was observed after cytomegalovirus infection of total-body gamma-irradiated mice, whereas in noncompromised hosts the lungs were not affected and virus multiplication was restricted to the salivary glands. The radiation damage c...
Repository :
Open Access LMU
Language(s) :
Undetermined