Results
author = "Herens, Christian"
Translocation (2;3)(P21;Q26) as the Sole Anomaly in a Case of Primary Myelofibrosis
Author(s) :
Herens, Christian
,
Hermanne, J. P.
,
Tassin, Françoise
,
Fassotte, M. F.
,
Thiry, Albert
,
Jamar, Michelle
,
Schaaf-Lafontaine, Nicole
Description :
Translocation t(2p;3q) is a rare but recurrent finding in myeloid disorders. We present the first case of primary myelofibrosis with t(2;3)(p21;q26) as the sole chromosomal anomaly. The comparison with the 11 other previously published myeloid-associated t(2p;3q) cases confirms that this nonrandom t...
Repository :
ORBi (University of Liège)
Language(s) :
English
Les syndromes myélodysplasiques: syndromes préleucémiques Myelodysplastic Syndromes: Preleukemic Syndromes
Author(s) :
Tassin, Françoise
,
Hermanne, Jean-Philippe
,
Schaaf-Lafontaine, Nicole
,
Herens, Christian
,
Thiry, Albert
,
Paulus, Jean-Michel
Description :
The myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by peripheral blood cytopenias with a hypercellular bone marrow exhibiting dyspoiesis. The predominant in elderly patients are associated with a high risk of progression to acute myelogenous leukemia. The etiolo...
Repository :
ORBi (University of Liège)
Language(s) :
French
Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas.
Author(s) :
Turkheimer, Federico E
,
Roncaroli, Federico
,
Hennuy, Benoît
,
Herens, Christian
,
Nguyen Khac, Minh-Tuan
,
Martin, Didier
Description :
BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that their coordinated expression depends on their position on chromosomes has highlighted the need for m...
Repository :
ORBi (University of Liège)
Language(s) :
English
Low T-cell chimerism is not followed by graft rejection after nonmyeloablative stem cell transplantation (NMSCT) with CD34-selected PBSC.
Author(s) :
Baron, Frédéric
,
Baudoux, Etienne
,
Frere, Pascale
,
Tourqui, Soraya
,
Schaaf-Lafontaine, Nicole
,
Herens, Christian
Description :
We investigate the feasibility of CD34-selected peripheral blood stem cell (PBSC) transplantation followed by pre-emptive CD8-depleted donor lymphocyte infusions (DLI) after a minimal conditioning regimen. Six patients with advanced hematological malignancies ineligible for a conventional myeloablat...
Repository :
ORBi (University of Liège)
Language(s) :
English
Deletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients.
Author(s) :
Herens, Christian
,
Tassin, Françoise
,
Lemaire, Véronique
,
Beguin, Yves
,
Collard, E.
,
Lampertz, S.
,
Croisiau, C.
,
Lecomte, Michèle
Description :
Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-AB...
Repository :
ORBi (University of Liège)
Language(s) :
English
Nonmyeloablative stem cell transplantation with CD8-depleted or CD34-selected peripheral blood stem cells.
Author(s) :
Baron, Frédéric
,
Baudoux, Etienne
,
Frere, Pascale
,
Tourqui, Soraya
,
Schaaf-Lafontaine, Nicole
,
Greimers, Roland
Description :
To decrease the incidence of graft-versus-host disease (GVHD) observed after nonmyeloablative stem cell transplantation (NMSCT), we studied the feasibility of CD8-depleted or CD34-selected NMSCT followed by CD8-depleted preemptive donor lymphocyte infusion (DLI) given in incremental doses on days 40...
Repository :
ORBi (University of Liège)
Language(s) :
English
Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas
Author(s) :
Turkheimer, Federico E
,
Roncaroli, Federico
,
Hennuy, Benoit
,
Herens, Christian
,
Nguyen, Minh
,
Martin, Didier
,
Evrard, Annick
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene.
Author(s) :
Colige, Alain
,
Nuytinck, Lieve
,
Hausser, Ingrid
,
van Essen, Anthonie J
,
Thiry, Marc
,
Herens, Christian
,
Ades, Lesley C
Description :
Ehlers-Danlos syndrome (EDS) type VIIC, or dermatosparactic type, is a recessively inherited connective tissue disorder characterized, among other symptoms, by an extreme skin fragility resulting from mutations inactivating ADAMTS-2, an enzyme excising the aminopropeptide of procollagens type I, II,...
Repository :
ORBi (University of Liège)
Language(s) :
English
Non-myeloablative transplantation with CD8-depleted or unmanipulated peripheral blood stem cells: a phase II randomized trial.
Author(s) :
Willems, Evelyne
,
Baron, Frédéric
,
Baudoux, Etienne
,
Wanten, Nadine
,
Seidel, Laurence
,
Vanbellinghen, Jean-François
Description :
Repository :
ORBi (University of Liège)
Language(s) :
English
Evidence for neo-generation of T cells by the thymus after non-myeloablative conditioning.
Author(s) :
Castermans, Emilie
,
Baron, Frédéric
,
Willems, Evelyne
,
Schaaf-Lafontaine, Nicole
,
Meuris, Nathalie
,
Gothot, André
Description :
BACKGROUND: Background and objective. We investigated immune recovery in 50 patients given either unmanipulated or CD8-depleted allogeneic peripheral blood stem cells after non-myeloablative conditioning. DESIGN AND METHODS: Fifty patients were randomized to receive either CD8-depleted (n=22) or non...
Repository :
ORBi (University of Liège)
Language(s) :
English