Results
author = "Hanson, Julien"
1
Found 10 documents, displaying page 3 of 1
Design, synthesis and pharmacological evaluation of sulfonylureas and sulfonycyanoguanidines as thromboxane A2 receptor antagonists. Insights into selectivity between thromboxane A2 receptor isoforms (TPα et TPβ)
Author(s) :
Hanson, Julien
Description :
Repository :
ORBi (University of Liège)
Language(s) :
English
Mechanism of Nicotinic acid-induced Flushing
Author(s) :
Hanson, Julien
Description :
Repository :
ORBi (University of Liège)
Language(s) :
English
Role of Keratinocytes GPR109A and COX-2 in Nicotinic Acid and Mono-methyl Fumarate Induced Flushing
Author(s) :
Hanson, Julien
,
Gille, Andreas
,
Zwykiel, Sabrina
,
Lukasova, Martina
,
Clausen, Bjorn
,
Ahmed, Kashan
,
Tunaru, Sorin
Description :
Repository :
ORBi (University of Liège)
Language(s) :
English
Effects of BM-573, a thromboxane A(2) modulator on systemic hemodynamics perturbations induced by U-46619 in the pig
Author(s) :
Tchana-Sato, Vincent
,
Dogné, Jean-Michel
,
Lambermont, Bernard
,
Ghuysen, Alexandre
,
Magis, David
,
Morimont, Philippe
Description :
The aim of our study was to evaluate the effects of thromboxane A(2) (TXA(2)) agonist, U-46619, on systemic circulatory parameters in the pigs before and after administration of a novel TXA(2) receptor antagonist and synthase inhibitor (BM-573). Twelve anesthetized pigs were randomly assigned in two...
Repository :
ORBi (University of Liège)
Language(s) :
English
Characterisation of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig
Author(s) :
Dogné, Jean-Michel
,
Rolin, S.
,
Tchana-Sato, Vincent
,
Petein, M.
,
Lambermont, Bernard
,
Ghuysen, Alexandre
,
Hanson, Julien
Description :
Repository :
ORBi (University of Liège)
Language(s) :
English
Deorphanization of GPR109B as a Receptor for the β-Oxidation Intermediate 3-OH-octanoic Acid and Its Role in the Regulation of Lipolysis*
Author(s) :
Ahmed, Kashan
,
Tunaru, Sorin
,
Langhans, Claus-Dieter
,
Hanson, Julien
,
Michalski, Christoph W.
,
Kölker, Stefan
,
Jones, Patricia M.
Description :
The orphan G-protein-coupled receptor GPR109B is the result of a recent gene duplication of the nicotinic acid and ketone body receptor GPR109A being found in humans but not in rodents. Like GPR109A, GPR109B is predominantly expressed in adipocytes and is supposed to mediate antilipolytic effects. H...
Repository :
Europe PubMed Central
Language(s) :
English
Nicotinic acid– and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice
Author(s) :
Hanson, Julien
,
Gille, Andreas
,
Zwykiel, Sabrina
,
Lukasova, Martina
,
Clausen, Björn E.
,
Ahmed, Kashan
,
Tunaru, Sorin
Description :
The antidyslipidemic drug nicotinic acid and the antipsoriatic drug monomethyl fumarate induce cutaneous flushing through activation of G protein–coupled receptor 109A (GPR109A). Flushing is a troublesome side effect of nicotinic acid, but may be a direct reflection of the wanted effects of monometh...
Repository :
Europe PubMed Central
Language(s) :
English
Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion
Author(s) :
Lanoye, Lieve
,
Segers, Patrick
,
Tchana-Sato, Vincent
,
Rolin, Stéphanie
,
Dogné, Jean-Michel
,
Ghuysen, Alexandre
Description :
Although reperfusion after coronary occlusion is mandatory for myocardial salvage, reperfusion may trigger a cascade of harmful events (reperfusion injury) adding to myocardial injury. We investigated effects of reperfusion on left ventricular (LV) haemodynamics and ventriculo-arterial (VA) coupling...
Repository :
ORBi (University of Liège)
Language(s) :
English
Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig
Author(s) :
Dogné, Jean-Michel
,
Rolin, Stéphanie
,
Petein, Michel
,
Tchana-Sato, Vincent
,
Ghuysen, Alexandre
,
Lambermont, Bernard
Description :
Background: Great advances have been made in the prevention of thrombotic disorders by developments of new pharmacological and surgical treatments. Animal models of arterial thrombosis have largely contributed to the discovery and to the validation of original treatments. The purpose of the present ...
Repository :
ORBi (University of Liège)
Language(s) :
English
Evaluation of BM-573, a novel TXA(2) synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion
Author(s) :
Kolh, Philippe
,
Rolin, S.
,
Tchana-Sato, Vincent
,
Petein, M.
,
Ghuysen, Alexandre
,
Lambermont, Bernard
,
Hanson, Julien
Description :
Aims: To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylam\ino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A(2) synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs. Methods: Twelve animals were randomly divided in two ...
Repository :
ORBi (University of Liège)
Language(s) :
English
1
Found 10 documents, displaying page 3 of 1