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author = "Guéranger, Quentin"
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Found 4 documents, displaying page 1 of 1

Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA

Author(s) : Gueranger, Quentin , Kia, Azadeh , Frith, David , Karran, Peter
Description : The DNA of patients taking immunosuppressive and anti-inflammatory thiopurines contains 6-thioguanine (6-TG) and their skin is hypersensitive to ultraviolet A (UVA) radiation. DNA 6-TG absorbs UVA and generates reactive oxygen species that damage DNA and proteins. Here, we show that the DNA damage i...
Repository : Europe PubMed Central
Language(s) : English

Competitive repair pathways in immunoglobulin gene hypermutation

Author(s) : Reynaud, Claude-Agnès , Delbos, Frédéric , Faili, Ahmad , Guéranger, Quentin , Aoufouchi, Said , Weill, Jean-Claude
Description : This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Polη) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated dea...
Repository : Europe PubMed Central
Language(s) : English

Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.

Author(s) : Gueranger, Quentin , Stary, Anne , Aoufouchi, Saïd , Faili, Ahmad , Sarasin, Alain , Reynaud, Claude-Agnès , Weill, Jean-Claude
Description : Genes coding for DNA polymerases eta, iota and zeta, or for both Pol eta and Pol iota have been inactivated by homologous recombination in the Burkitt's lymphoma BL2 cell line, thus providing for the first time the total suppression of these enzymes in a human context. The UV sensitivities and UV-in...
Repository : HAL - Hyper Article on Line
Language(s) : English

Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links▿ †

Author(s) : Hicks, J. Kevin , Chute, Colleen L. , Paulsen, Michelle T. , Ragland, Ryan L. , Howlett, Niall G. , Guéranger, Quentin
Description : Translesion DNA synthesis (TLS) is a process whereby specialized DNA polymerases are recruited to bypass DNA lesions that would otherwise stall high-fidelity polymerases. We provide evidence that TLS across cisplatin intrastrand cross-links is performed by multiple translesion DNA polymerases. First...
Repository : Europe PubMed Central
Language(s) : English
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Found 4 documents, displaying page 1 of 1