Results
author = "Gladwin, Mark T."
Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease
Author(s) :
Gordeuk, Victor R.
,
Campbell, Andrew
,
Rana, Sohail
,
Nouraie, Mehdi
,
Niu, Xiaomei
,
Minniti, Caterina P.
,
Sable, Craig
Description :
Hydroxyurea and higher hemoglobin F improve the clinical course and survival in sickle cell disease, but their roles in protecting from pulmonary hypertension are not clear. We studied 399 children and adolescents with sickle cell disease at steady state; 38% were being treated with hydroxyurea. Pat...
Repository :
Europe PubMed Central
Language(s) :
English
Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension
Author(s) :
Linguraru, Marius George
,
Pura, John A.
,
Van Uitert, Robert L.
,
Mukherjee, Nisha
,
Summers, Ronald M.
,
Minniti, Caterina
Description :
Purpose: Pulmonary arterial hypertension (PAH) is a progressive vascular disease that results in high mortality and morbidity in sickle cell disease (SCD) patients. PAH diagnosis is invasive via right heart catheterization, but manual measurements of the main pulmonary artery (PA) diameters from com...
Repository :
Europe PubMed Central
Language(s) :
English
Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats
Author(s) :
Alef, Matthew J.
,
Vallabhaneni, Raghuveer
,
Carchman, Evie
,
Morris, Sidney M.
,
Shiva, Sruti
,
Wang, Yinna
,
Kelley, Eric E.
Description :
Vascular disease, a significant cause of morbidity and mortality in the developed world, results from vascular injury. Following vascular injury, damaged or dysfunctional endothelial cells and activated SMCs engage in vasoproliferative remodeling and the formation of flow-limiting intimal hyperplasi...
Repository :
Europe PubMed Central
Language(s) :
English
Pulmonary Vascular Lesions Are Common in SIV- and SHIV-env-Infected Macaques
Author(s) :
George, M. Patricia
,
Brower, Alexandra
,
Kling, Heather
,
Shipley, Tim
,
Kristoff, Jan
,
Reinhart, Todd A.
,
Murphey-Corb, Michael
Description :
The lack of animal models of HIV-related pulmonary arterial hypertension (HIV-PAH) severely limits investigation of this serious disease. While histological evidence of HIV-PAH has been demonstrated in macaques infected with simian immunodeficiency virus (SIV) as well as with chimeric simian/human i...
Repository :
Europe PubMed Central
Language(s) :
English
Predictors of osteoclast activity in patients with sickle cell disease
Author(s) :
Nouraie, Mehdi
,
Cheng, Kevin
,
Niu, Xiaomei
,
Moore-King, Evadne
,
Fadojutimi-Akinsi, Margaret F.
,
Minniti, Caterina P.
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Human Neuroglobin Functions as a Redox-regulated Nitrite Reductase*
Author(s) :
Tiso, Mauro
,
Tejero, Jesús
,
Basu, Swati
,
Azarov, Ivan
,
Wang, Xunde
,
Simplaceanu, Virgil
,
Frizzell, Sheila
,
Jayaraman, Thottala
Description :
Neuroglobin is a highly conserved hemoprotein of uncertain physiological function that evolved from a common ancestor to hemoglobin and myoglobin. It possesses a six-coordinate heme geometry with proximal and distal histidines directly bound to the heme iron, although coordination of the sixth ligan...
Repository :
Europe PubMed Central
Language(s) :
English
14-3-3 Binding and Phosphorylation of Neuroglobin during Hypoxia Modulate Six-to-Five Heme Pocket Coordination and Rate of Nitrite Reduction to Nitric Oxide*
Author(s) :
Jayaraman, Thottala
,
Tejero, Jesús
,
Chen, Bill B.
,
Blood, Arlin B.
,
Frizzell, Sheila
,
Shapiro, Calli
,
Tiso, Mauro
Description :
Background: Neuroglobin protects neurons from hypoxia; however, the underlying mechanisms for this effect remain poorly understood.
Repository :
Europe PubMed Central
Language(s) :
English
Erythrocytes are the major intravascular storage sites of nitrite in human blood
Author(s) :
Dejam, André
,
Hunter, Christian J.
,
Pelletier, Mildred M.
,
Hsu, Lewis L.
,
Machado, Roberto F.
,
Shiva, Sruti
,
Power, Gordon G.
Description :
Plasma levels of nitrite ions have been used as an index of nitric oxide synthase (NOS) activity in vivo. Recent data suggest that nitrite is a potential intravascular repository for nitric oxide (NO), bioactivated by a nitrite reductase activity of deoxyhemoglobin. The precise levels and compartmen...
Repository :
Europe PubMed Central
Language(s) :
English
Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin
Author(s) :
Minneci, Peter C.
,
Deans, Katherine J.
,
Zhi, Huang
,
Yuen, Peter S.T.
,
Star, Robert A.
,
Banks, Steven M.
,
Schechter, Alan N.
Description :
During intravascular hemolysis in human disease, vasomotor tone and organ perfusion may be impaired by the increased reactivity of cell-free plasma hemoglobin (Hb) with NO. We experimentally produced acute intravascular hemolysis in a canine model in order to test the hypothesis that low levels of d...
Repository :
Europe PubMed Central
Language(s) :
English
Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery
Author(s) :
Cannon, Richard O.
,
Schechter, Alan N.
,
Panza, Julio A.
,
Ognibene, Frederick P.
,
Pease-Fye, Margaret E.
,
Waclawiw, Myron A.
Description :
Nitric oxide (NO) may be stabilized by binding to hemoglobin, by nitrosating thiol-containing plasma molecules, or by conversion to nitrite, all reactions potentially preserving its bioactivity in blood. Here we examined the contribution of blood-transported NO to regional vascular tone in humans be...
Repository :
Europe PubMed Central
Language(s) :
English