Results
author = "Gladwin, Mark T."
Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturation
Author(s) :
Minniti, Caterina P.
,
Sable, Craig
,
Campbell, Andrew
,
Rana, Sohail
,
Ensing, Gregory
,
Dham, Niti
,
Onyekwere, Onyinye
Description :
An elevated echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. The study provides evidence for independent associations of elevated jet velocity with hemolysis and oxygen desaturation...
Repository :
Europe PubMed Central
Language(s) :
English
Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury
Author(s) :
Hendgen-Cotta, Ulrike B.
,
Merx, Marc W.
,
Shiva, Sruti
,
Schmitz, Joel
,
Becher, Stefanie
,
Klare, Johann P.
,
Steinhoff, Heinz-Jürgen
Description :
The nitrite anion is reduced to nitric oxide (NO•) as oxygen tension decreases. Whereas this pathway modulates hypoxic NO• signaling and mitochondrial respiration and limits myocardial infarction in mammalian species, the pathways to nitrite bioactivation remain uncertain. Studies suggest that hemog...
Repository :
Europe PubMed Central
Language(s) :
English
Pulmonary hypertension and NO in sickle cell
Author(s) :
Gladwin, Mark T.
,
Barst, Robyn J.
,
Castro, Oswaldo L.
,
Gordeuk, Victor R.
,
Hillery, Cheryl A.
,
Kato, Gregory J.
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans
Author(s) :
Gladwin, Mark T.
,
Shelhamer, James H.
,
Schechter, Alan N.
,
Pease-Fye, Margaret E.
,
Waclawiw, Myron A.
,
Panza, Julio A.
Description :
To determine the relative contributions of endothelial-derived
nitric oxide (NO) vs. intravascular nitrogen oxide species in the
regulation of human blood flow, we simultaneously measured forearm
blood flow and arterial and venous levels of plasma nitrite, LMW-SNOs
and HMW-SNOs, and red cell S-n...
Repository :
Europe PubMed Central
Language(s) :
English
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Author(s) :
Huang, Zhi
,
Shiva, Sruti
,
Kim-Shapiro, Daniel B.
,
Patel, Rakesh P.
,
Ringwood, Lorna A.
,
Irby, Cynthia E.
,
Huang, Kris T.
Description :
Hypoxic vasodilation is a fundamental, highly conserved physiological response that requires oxygen and/or pH sensing coupled to vasodilation. While this process was first characterized more than 80 years ago, the precise identity and mechanism of the oxygen sensor and mediators of vasodilation rema...
Repository :
Europe PubMed Central
Language(s) :
English
Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability
Author(s) :
Hsu, Lewis L.
,
Champion, Hunter C.
,
Campbell-Lee, Sally A.
,
Bivalacqua, Trinity J.
,
Manci, Elizabeth A.
,
Diwan, Bhalchandra A.
Description :
Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a strong risk factor for early mortality. However, the pathophysiologic mechanisms leading to pulmonary vasculopathy remain unclear. Transgenic mice provide opportunities for mechanistic studies of vascular patho...
Repository :
Europe PubMed Central
Language(s) :
English
A network model to predict the risk of death in sickle cell disease
Author(s) :
Sebastiani, Paola
,
Nolan, Vikki G.
,
Baldwin, Clinton T.
,
Abad-Grau, Maria M.
,
Wang, Ling
,
Adewoye, Adeboye H.
,
McMahon, Lillian C.
Description :
Modeling the complexity of sickle cell disease pathophysiology and severity is difficult. Using data from 3380 patients accounting for all common genotypes of sickle cell disease, Bayesian network modeling of 25 clinical events and laboratory tests was used to estimate sickle cell disease severity, ...
Repository :
Europe PubMed Central
Language(s) :
English
Increased nitrite reductase activity of fetal versus adult ovine hemoglobin
Author(s) :
Blood, Arlin B.
,
Tiso, Mauro
,
Verma, Shilpa T.
,
Lo, Jennifer
,
Joshi, Mahesh S.
,
Azarov, Ivan
,
Longo, Lawrence D.
Description :
Growing evidence indicates that nitrite, NO2−, serves as a circulating reservoir of nitric oxide (NO) bioactivity that is activated during physiological and pathological hypoxia. One of the intravascular mechanisms for nitrite conversion to NO is a chemical nitrite reductase activity of deoxyhemoglo...
Repository :
Europe PubMed Central
Language(s) :
English
Angiogenic and Inflammatory Markers of Cardiopulmonary Changes in Children and Adolescents with Sickle Cell Disease
Author(s) :
Niu, Xiaomei
,
Nouraie, Mehdi
,
Campbell, Andrew
,
Rana, Sohail
,
Minniti, Caterina P.
,
Sable, Craig
,
Darbari, Deepika
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia
Author(s) :
Gordeuk, Victor R.
,
Minniti, Caterina P.
,
Nouraie, Mehdi
,
Campbell, Andrew D.
,
Rana, Sohail R
,
Luchtman-Jones, Lori
Description :
Repository :
Europe PubMed Central
Language(s) :
English