Results
author = "Gladwin, Mark T."
Biological activity of nitric oxide in the plasmatic compartment
Author(s) :
Wang, Xunde
,
Tanus-Santos, Jose E.
,
Reiter, Christopher D.
,
Dejam, Andre
,
Shiva, Sruti
,
Smith, Reginald D.
,
Hogg, Neil
Description :
There exist reaction products of nitric oxide (NO) with blood that conserve its bioactivity and transduce an endocrine vasomotor function under certain conditions. Although S-nitrosated albumin has been considered the major species subserving this activity, recent data suggest that additional NO spe...
Repository :
Europe PubMed Central
Language(s) :
English
Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis
Author(s) :
Minneci, Peter C.
,
Deans, Katherine J.
,
Shiva, Sruti
,
Zhi, Huang
,
Banks, Steven M.
,
Kern, Steven
,
Natanson, Charles
Description :
Hemoglobin (Hb) potently inactivates the nitric oxide (NO) radical via a dioxygenation reaction forming nitrate (NO3−). This inactivation produces endothelial dysfunction during hemolytic conditions and may contribute to the vascular complications of Hb-based blood substitutes. Hb also functions as ...
Repository :
Europe PubMed Central
Language(s) :
English
Hydroxyurea-Induced Expression of Glutathione Peroxidase 1 in Red Blood Cells of Individuals with Sickle Cell Anemia
Author(s) :
Cho, Chun-Seok
,
Kato, Gregory J.
,
Yang, Seung Ha
,
Bae, Sung Won
,
Lee, Jong Seo
,
Gladwin, Mark T.
,
Rhee, Sue Goo
Description :
Chronic redox imbalance in erythrocytes of individuals with sickle cell disease (SCD) contributes to oxidative stress and likely underlies common etiologies of hemolysis. We measured the amounts of six antioxidant enzymes—SOD1, catalase, glutathione peroxidase 1 (GPx1), as well as peroxiredoxins (Pr...
Repository :
Europe PubMed Central
Language(s) :
English
Doppler-defined pulmonary hypertension in medical intensive care unit patients: Retrospective investigation of risk factors and impact on mortality
Author(s) :
Stamm, Jason A.
,
McVerry, Bryan J.
,
Mathier, Michael A.
,
Donahoe, Michael P.
,
Saul, Melissa I.
,
Gladwin, Mark T.
Description :
Pulmonary hypertension (PH) is poorly characterized in the critically ill. No prior studies describe the burden of or outcomes associated with PH in a general medical intensive care unit population. We hypothesize that PH is an important comorbidity prevalent in the modern medical intensive care uni...
Repository :
Europe PubMed Central
Language(s) :
English
Mechanisms of Slower Nitric Oxide Uptake by Red Blood Cells and Other Hemoglobin-containing Vesicles*
Author(s) :
Azarov, Ivan
,
Liu, Chen
,
Reynolds, Hannah
,
Tsekouras, Zaharo
,
Lee, Janet S.
,
Gladwin, Mark T.
,
Kim-Shapiro, Daniel B.
Description :
Nitric oxide (NO) acts as a smooth muscle relaxation factor and plays a crucial role in maintaining vascular homeostasis. NO is scavenged rapidly by hemoglobin (Hb). However, under normal physiological conditions, the encapsulation of Hb inside red blood cells (RBCs) significantly retards NO scaveng...
Repository :
Europe PubMed Central
Language(s) :
English
Hydroxyurea induces fetal hemoglobin by the nitric oxide–dependent activation of soluble guanylyl cyclase
Author(s) :
Cokic, Vladan P.
,
Smith, Reginald D.
,
Beleslin-Cokic, Bojana B.
,
Njoroge, Joyce M.
,
Miller, Jeffery L.
,
Gladwin, Mark T.
Description :
Hydroxyurea treatment of patients with sickle-cell disease increases fetal hemoglobin (HbF), which reduces hemoglobin S polymerization and clinical complications. Despite its use in the treatment of myeloproliferative diseases for over 30 years, its mechanism of action remains uncertain. Recent stud...
Repository :
Europe PubMed Central
Language(s) :
English
Hemodynamic and Functional Assessment of Patients with Sickle Cell Disease and Pulmonary Hypertension
Author(s) :
Anthi, Anastasia
,
Machado, Roberto F.
,
Jison, Maria L.
,
Taveira-DaSilva, Angelo M.
,
Rubin, Lewis J.
,
Hunter, Lori
Description :
Rationale: Although pulmonary hypertension (PH) is a common complication of sickle cell disease (SCD) associated with high mortality, there exist few data characterizing hemodynamics and cardiopulmonary function in this population.
Repository :
Europe PubMed Central
Language(s) :
English
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
Author(s) :
Aslan, Mutay
,
Ryan, Thomas M.
,
Adler, Brian
,
Townes, Tim M.
,
Parks, Dale A.
,
Thompson, J. Anthony
,
Tousson, Albert
Description :
Plasma xanthine oxidase (XO) activity was defined as a source
of enhanced vascular superoxide (O\documentclass[12pt]{minimal}
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Repository :
Europe PubMed Central
Language(s) :
English
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
Author(s) :
Kato, Gregory J.
,
McGowan, Vicki
,
Machado, Roberto F.
,
Little, Jane A.
,
Taylor, James
,
Morris, Claudia R.
,
Nichols, James S.
Description :
Pulmonary hypertension is prevalent in adult patients with sickle cell disease and is strongly associated with early mortality and markers of hemolysis, in particular, serum lactate dehydrogenase (LDH). Intravascular hemolysis leads to impaired bioavailability of nitric oxide (NO), mediated by NO sc...
Repository :
Europe PubMed Central
Language(s) :
English
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
Author(s) :
Crawford, Jack H.
,
Isbell, T. Scott
,
Huang, Zhi
,
Shiva, Sruti
,
Chacko, Balu K.
,
Schechter, Alan N.
,
Darley-Usmar, Victor M.
Description :
Local vasodilation in response to hypoxia is a fundamental physiologic response ensuring oxygen delivery to tissues under metabolic stress. Recent studies identify a role for the red blood cell (RBC), with hemoglobin the hypoxic sensor. Herein, we investigate the mechanisms regulating this process a...
Repository :
Europe PubMed Central
Language(s) :
English