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author = "Gillespie, J. Robert"
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Found 2 documents, displaying page 1 of 1

Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy▿

Author(s) : Ojo, Kayode K. , Gillespie, J. Robert , Riechers, Aaron J. , Napuli, Alberto J. , Verlinde, Christophe L. M. J. , Buckner, Frederick S.
Description : Development of a safe, effective, and inexpensive therapy for African trypanosomiasis is an urgent priority. In this study, we evaluated the validity of Trypanosoma brucei glycogen synthase kinase 3 (GSK-3) as a potential drug target. Interference with the RNA of either of two GSK-3 homologues in bl...
Repository : Europe PubMed Central
Language(s) : English

Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice▿†

Author(s) : Shibata, Sayaka , Gillespie, J. Robert , Kelley, Angela M. , Napuli, Alberto J. , Zhang, Zhongsheng , Kovzun, Kuzma V.
Description : Human African trypanosomiasis continues to be an important public health threat in extensive regions of sub-Saharan Africa. Treatment options for infected patients are unsatisfactory due to toxicity, difficult administration regimes, and poor efficacy of available drugs. The aminoacyl-tRNA synthetas...
Repository : Europe PubMed Central
Language(s) : English
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Found 2 documents, displaying page 1 of 1