flag flag  

Search all repositories
add criteria
Close advanced options Search for

 

Enter more search criteria
Publication Date
     
From
To
Document Language
Document Type
Repositories
New Search Save Search Refine Search
Results
author = "Gangloff, Monique"
1

Found 6 documents, displaying page 1 of 1

Different dimerisation mode for TLR4 upon endosomal acidification?

Author(s) : Gangloff, Monique
Description : TLR4 is unique among pathogen-recognition receptors in that it initiates different pathways in different cellular locations. Binding of a bridging factor, Mal, allows recruitment of an adapter protein, MyD88, at the plasma membrane, which leads to the production of proinflammatory cytokines. Upon in...
Repository : Europe PubMed Central
Language(s) : English

Cleaved thioredoxin fusion protein enables the crystallization of poorly soluble ERα in complex with synthetic ligands

Author(s) : Cura, Vincent , Gangloff, Monique , Eiler, Sylvia , Moras, Dino , Ruff, Marc
Description : A new crystallization strategy: the presence of cleaved thioredoxin fusion is critical for crystallization of the estrogen nuclear receptor ligand binding domain in complex with synthetic ligands. This novel technique should be regarded as an interesting alternative for crystallization of difficult ...
Repository : Europe PubMed Central
Language(s) : English

Molecular Mechanism That Induces Activation of Spätzle, the Ligand for the Drosophila Toll Receptor

Author(s) : Arnot, Christopher J. , Gay, Nicholas J. , Gangloff, Monique
Description : The Drosophila Toll receptor is activated by an endogenous cytokine ligand Spätzle. Active ligand is generated in response to positional cues in embryonic dorso-ventral patterning and microbial pathogens in the insect immune response. Spätzle is secreted as a pro-protein and is processed into an act...
Repository : Europe PubMed Central
Language(s) : English

Estrogen receptor transcription and transactivation: Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors

Author(s) : Ruff, Marc , Gangloff, Monique , Marie Wurtz, Jean , Moras, Dino
Description : Estrogen receptors are members of the nuclear receptor steroid family that exhibit specific structural features, ligand-binding domain sequence identity and dimeric interactions, that single them out. The crystal structures of their DNA-binding domains give some insight into how nuclear receptors di...
Repository : Europe PubMed Central
Language(s) : English

LPS ligand and culture additives improve production of monomeric MD-1 and 2 in Pichia pastoris by decreasing aggregation and intermolecular disulfide bonding

Author(s) : Mengwasser, Kristen E. , Bryant, Clare E. , Gay, Nick J. , Gangloff, Monique
Description : Myeloid differentiation proteins MD-1 and MD-2 have both been shown to form a heterogeneous collection of oligomers when expressed in absence of their respective receptor, RP105 and TLR4. The biological relevance of these oligomers is not clear. Only monomeric proteins have been found to be active a...
Repository : Europe PubMed Central
Language(s) : English

Functional Insights from the Crystal Structure of the N-Terminal Domain of the Prototypical Toll Receptor

Author(s) : Gangloff, Monique , Arnot, Christopher J. , Lewis, Miranda , Gay, Nicholas J.
Description : Drosophila melanogaster Toll is the founding member of an important family of pathogen-recognition receptors in humans, the Toll-like receptor (TLR) family. In contrast, the prototypical receptor is a cytokine-like receptor for Spätzle (Spz) protein and plays a dual role in both development and immu...
Repository : Europe PubMed Central
Language(s) : English
1

Found 6 documents, displaying page 1 of 1