Results
author = "Froesch, E R"
Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes.
Description :
Adult rat cardiomyocytes in long-term culture
express type 1 insulin-like growth factor (IGF) receptors. In contrast to
insulin receptors, type 1 IGF receptors are up-regulated during culturing. IGF-I
added to the cells at plating increased granular density and pseudopodia number
per cell after 7 da...
Repository :
Europe PubMed Central
Language(s) :
English
Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats.
Description :
Stimulation of erythropoiesis during growth is necessary to ensure proportionality between erythrocyte mass and body mass. However, the way by which erythrocyte formation is adapted to body growth is still unknown. Growth arrest in hypophysectomized rats is accompanied by decreased erythropoiesis. W...
Repository :
Europe PubMed Central
Language(s) :
English
Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans.
Author(s) :
Hussain, M A
,
Schmitz, O
,
Mengel, A
,
Keller, A
,
Christiansen, J S
,
Zapf, J
,
Froesch, E R
Description :
To elucidate the effects of insulin-like growth factor I (IGF-I) on fuel oxidation and insulin sensitivity, eight healthy subjects were treated with saline and recombinant human (IGF-I (10 micrograms/kg.h) during 5 d in a crossover, randomized fashion, while receiving an isocaloric diet (30 kcal/kg....
Repository :
Europe PubMed Central
Language(s) :
English
Nonsuppressible insulin-like activity and thyroid hormones: major pituitary-dependent sulfation factors for chick embryo cartilage.
Description :
Serum from hypothyroid hypophysectomized rats did not stimulate sulfation or incorporation of amino acids into chick embryo sterna. When such rats were treated for a short time with growth hormone (somatotropin), their serum stimulated incorporation both of sulfate and of amino acids. The different ...
Repository :
Europe PubMed Central
Language(s) :
English
ANTIBODY-SUPPRESSIBLE AND NONSUPPRESSIBLE INSULIN-LIKE ACTIVITIES IN HUMAN SERUM AND THEIR PHYSIOLOGIC SIGNIFICANCE. AN INSULIN ASSAY WITH ADIPOSE TISSUE OF INCREASED PRECISION AND SPECIFICITY*
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Inhibition of the Action of Nonsuppressible Insulin-Like Activity on Isolated Rat Fat Cells by Binding to its Carrier Protein
Description :
Nonsuppressible insulin-like activity extracted and purified from human serum (NSILA-S) mimics all insulin-like effects in vitro and, after injection, in vivo in the presence of excess insulin antibodies. However, there is no evidence that it exerts acute insulin-like effects in its native form in t...
Repository :
Europe PubMed Central
Language(s) :
English
Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans.
Author(s) :
Hussain, M A
,
Schmitz, O
,
Mengel, A
,
Glatz, Y
,
Christiansen, J S
,
Zapf, J
,
Froesch, E R
Description :
Insulin-like growth factor-I (IGF-I) is considered to be the mediator of the growth-promoting effects of growth hormone (GH). The metabolic effects of these two hormones, however, are different. Whereas GH treatment leads to elevated insulin and glucose levels, reduced insulin sensitivity, and impai...
Repository :
Europe PubMed Central
Language(s) :
English
Intravenously injected insulin-like growth factor (IGF) I/IGF binding protein-3 complex exerts insulin-like effects in hypophysectomized, but not in normal rats.
Description :
Insulin-like growth factor (IGF) circulates in blood in two large molecular mass forms of 150 and 40 kD. Under normal conditions, most of the IGF is bound to the 150-kD complex by which it is retained in the circulation and therefore unable to exert acute insulin-like actions. The aim of this study ...
Repository :
Europe PubMed Central
Language(s) :
English
Human fetal and adult chondrocytes. Effect of insulinlike growth factors I and II, insulin, and growth hormone on clonal growth.
Description :
Clonal proliferation of freshly isolated human fetal chondrocytes and adult chondrocytes in response to human insulinlike growth factors I and II (IGF I, IGF II), human biosynthetic insulin, and human growth hormone (GH) was assessed. IGF I (25 ng/ml) stimulated clonal growth of fetal chondrocytes (...
Repository :
Europe PubMed Central
Language(s) :
English
Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus.
Description :
Hyperglycemia, hyperinsulinemia, and insulin resistance cause vascular disease in type 2 diabetes mellitus. Dietary treatment alone often fails and oral drugs or insulin enhance hyperinsulinemia. In previous studies, an intravenous bolus of recombinant human insulin-like growth factor-I (rhIGF-I) ca...
Repository :
Europe PubMed Central
Language(s) :
English