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author = "Friedman, R."
<< < 3 4 5 6 7 > >>

Found 107 documents, displaying page 5 of 11

Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functions.

Author(s) : Friedman, R L , Fiederlein, R L , Glasser, L , Galgiani, J N
Description : Affinity-purified adenylate cyclase (AC) of Bordetella pertussis, free of contaminating pertussis toxin, was demonstrated to have biological effects on human polymorphonuclear leukocytes (PMN). AC at doses of 25 and 50 micrograms/ml increased intracellular cAMP levels in the phagocytes 7.6- to 23.5-...
Repository : Europe PubMed Central
Language(s) : English

Isolation and characterization of a Pseudomonas aeruginosa mutant producing a nontoxic, immunologically crossreactive toxin A protein.

Author(s) : Cryz, S J , Friedman, R L , Iglewski, B H
Description : Nitrosoguanidine mutagenesis of Pseudomonas aeruginosa strain PAO-1 yielded a mutant strain, PAO-PR1, which produced a protein that was immunologically indistinguishable from native toxin A and was nontoxic for cultured Chinese hamster ovary cells. In contrast to native toxin, the cell-associated an...
Repository : Europe PubMed Central
Language(s) : English

Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats.

Author(s) : Woods, D E , Cryz, S J , Friedman, R L , Iglewski, B H
Description : A chronic pulmonary infection model in rats was employed to assess the role of individual Pseudomonas aeruginosa exoproducts in disease due to this organism. Groups of rats were inoculated transtracheally with agar beads in which were embedded approximately 10(4) colony-forming units of P. aerugijno...
Repository : Europe PubMed Central
Language(s) : English

Magnetic field of a single muscle fiber. First measurements and a core conductor model.

Author(s) : van Egeraat, J M , Friedman, R N , Wikswo, J P
Description : We present the first measurements of the magnetic field from a single muscle fiber of the frog gastrocnemius, obtained by using a toroidal pickup coil coupled to a room-temperature, low-noise amplifier. The axial currents associated with the magnetic fields of single fibers were biphasic and had pea...
Repository : Europe PubMed Central
Language(s) : English

Genetic studies of human acidic salivary protein (Pa).

Author(s) : Friedman, R D , Merritt, A D , Rivas, M L
Description : The phenotypic expression of a dominantly inherited human salivary acidic protein (Pa) has been described in acid-urea starch and in Tris-borate acrylamide gel systems. Estimates of the Pa+ allelic frequencies in American Caucasians, American blacks, and Orientals are .21, .14, and .42, respectively...
Repository : Europe PubMed Central
Language(s) : English

Identification of a Bordetella pertussis regulatory factor required for transcription of the pertussis toxin operon in Escherichia coli.

Author(s) : DeShazer, D , Wood, G E , Friedman, R L
Description : Transcription of the pertussis toxin operon (ptx) is positively regulated in Bordetella pertussis by the bvgAS locus. However, a ptx-lacZ transcriptional fusion in Escherichia coli cannot be activated by bvgAS in trans. This suggests that an additional factor(s) is required for transcription of ptx....
Repository : Europe PubMed Central
Language(s) : English

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

Author(s) : Perry, G , Friedman, R , Shaw, G , Chau, V
Description : Neurofibrillary tangles (NFT) and neurites associated with senile plaques (SP) in Alzheimer disease-affected brain tissues were specifically immunostained with affinity-purified antibody preparations directed against ubiquitin. In addition, a class of neurites seen in brain regions containing NFT an...
Repository : Europe PubMed Central
Language(s) : English

Tunicamycin treatment inhibits the antiviral activity of interferon in mice.

Author(s) : Maheshwari, R K , Husain, M M , Attallah, A M , Friedman, R M
Description : Earlier we reported that tunicamycin (TM) treatment of L cells in vitro significantly enhances the antiviral activity of interferon (IFN) against viruses (such as vesicular stomatitis, Sindbis, and herpes simplex) which bud from membranes. However, no such enhancement of the antiviral activity of IF...
Repository : Europe PubMed Central
Language(s) : English

Identification of a cytotoxin produced by Legionella pneumophila.

Author(s) : Friedman, R L , Iglewski, B H , Miller, R D
Description : Culture filtrates of Legionella pneumophila were cytotoxic for Chinese hamster ovary cells. The cytotoxin was found to be methanol soluble, heat stable, and stable from pH 5 through 8.
Repository : Europe PubMed Central
Language(s) : English

Development of a rapid diagnostic test for pertussis: direct detection of pertussis toxin in respiratory secretions.

Author(s) : Friedman, R L , Paulaitis, S , McMillan, J W
Description : Monoclonal antibodies (MAb) were produced against the specific Bordetella pertussis antigen pertussis toxin (PT). In preliminary studies, one MAb (IB12) was selected and used in an enzyme-linked dot blot immunoassay to evaluate the ability of the method to detect known amounts of PT in control exper...
Repository : Europe PubMed Central
Language(s) : English
<< < 3 4 5 6 7 > >>

Found 107 documents, displaying page 5 of 11