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author = "Foksinski, Marek"
1
Found 8 documents, displaying page 1 of 1
Urinary measurement of 8-OxodG, 8-OxoGua, and 5HMUra: a noninvasive assessment of oxidative damage to DNA.
Author(s) :
Olinski, Ryszard
,
Rozalski, Rafal
,
Gackowski, Daniel
,
Foksinski, Marek
,
Siomek, Agnieszka
,
Cooke, Marcus S.
Description :
Numerous DNA repair pathways exist to prevent the persistence of damage, and are integral to the maintenance of genome stability, and hence prevention of disease. Excised lesions arising from repair may ultimately appear in the urine where their measurement has been acknowledged to be reflective of ...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Involvement of oxidatively damaged DNA and repair in cancer development and aging
Author(s) :
Tudek, Barbara
,
Winczura, Alicja
,
Janik, Justyna
,
Siomek, Agnieszka
,
Foksinski, Marek
,
Oliński, Ryszard
Description :
DNA damage and DNA repair may mediate several cellular processes, like replication and transcription, mutagenesis and apoptosis and thus may be important factors in the development and pathology of an organism, including cancer. DNA is constantly damaged by reactive oxygen species (ROS) and reactive...
Repository :
Europe PubMed Central
Language(s) :
English
Effects of basal level of antioxidants on oxidative DNA damage in humans.
Author(s) :
Foksinski, Marek
,
Gackowski, Daniel
,
Rozalski, Rafal
,
Siomek, Agnieszka
,
Guz, Jolanta
,
Szpila, Anna
,
Dziaman, Tomasz
Description :
BACKGROUND: Vitamins A, E and C, and uric acid, which can scavenge free radicals should also protect DNA from the damage. It is reasonable to assume that agents that decrease oxidative DNA damage should also decrease subsequent cancer development. AIM OF THE STUDY: A relationship between basal level...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Oxidative damage to DNA and antioxidant status in aging and age-related diseases.
Author(s) :
Olinski, Ryszard
,
Siomek, Agnieszka
,
Rozalski, Rafal
,
Gackowski, Daniel
,
Foksinski, Marek
,
Guz, Jolanta
,
Dziaman, Tomasz
Description :
Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
The relationship between 8-oxo-7,8-dihydro-2'-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas.
Author(s) :
Guz, Jolanta
,
Foksinski, Marek
,
Siomek, Agnieszka
,
Gackowski, Daniel
,
Rozalski, Rafal
,
Dziaman, Tomasz
,
Szpila, Anna
Description :
It has been known for a long time that DNA hypomethylation occurs in many human cancers and precancerous conditions. However, the mechanisms of hypomethylation are largely unknown. It is possible that endogenous 8-oxo-7,8-dihydroguanine (8-oxoGua) level may be linked to aberrant DNA methylation of a...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism.
Author(s) :
Roszkowski, Krzysztof
,
Gackowski, Daniel
,
Rozalski, Rafal
,
Dziaman, Tomasz
,
Siomek, Agnieszka
,
Guz, Jolanta
,
Szpila, Anna
Description :
It is possible that oxidatively damaged DNA which arises as a result of radiotherapy may be involved in the therapeutic effect of the ionizing radiation and in the side effects. Therefore, for the first time, the broad spectrum of oxidatively damaged DNA biomarkers: urinary excretion of 8-oxodG (8-o...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Cu,Zn-superoxide dismutase deficiency in mice leads to organ-specific increase in oxidatively damaged DNA and NF-κB1 protein activity.
Author(s) :
Siomek, Agnieszka
,
Brzoska, Kamil
,
Sochanowicz, Barbara
,
Gackowski, Daniel
,
Rozalski, Rafal
,
Foksinski, Marek
,
Zarakowska, Ewelina
Description :
Earlier experimental studies have demonstrated that: i) Cu,Zn-superoxide dismutase deficiency leads to oxidative stress and carcinogenesis; ii) dysregulation of NF-κB pathway can mediate a wide variety of diseases, including cancer. Therefore, we decided, for the first time, to examine the level of ...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Interlaboratory comparison of methodologies for the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine.
Author(s) :
Cooke, Marcus S.
,
Barregard, Lars
,
Mistry, Vilas
,
Potdar, Neelam
,
Rozalski, Rafal
,
Gackowski, Daniel
,
Siomek, Agnieszka
Description :
Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) is widely used as a marker of oxidative stress. Here we report the comparison of two, distinct chromatographic assays with an enzyme-linked immunosorbent assay (ELISA). The chromatographic assays displayed good agreement (r =:0.89, p < 0.0001),...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
1
Found 8 documents, displaying page 1 of 1