Results
author = "Faili, Ahmad"
Competitive repair pathways in immunoglobulin gene hypermutation
Author(s) :
Reynaud, Claude-Agnès
,
Delbos, Frédéric
,
Faili, Ahmad
,
Guéranger, Quentin
,
Aoufouchi, Said
,
Weill, Jean-Claude
Description :
This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Polη) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated dea...
Repository :
Europe PubMed Central
Language(s) :
English
DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
Author(s) :
Delbos, Frédéric
,
Aoufouchi, Said
,
Faili, Ahmad
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2–MSH6 proteins, together with DNA polymerase η (pol η). However, residual A/T mutagenesis is still observed up...
Repository :
Europe PubMed Central
Language(s) :
English
Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse
Author(s) :
Delbos, Frédéric
,
De Smet, Annie
,
Faili, Ahmad
,
Aoufouchi, Said
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase η, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V p...
Repository :
Europe PubMed Central
Language(s) :
English
DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.
Author(s) :
Delbos, Frédéric
,
Aoufouchi, Said
,
Faili, Ahmad
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6 proteins, together with DNA polymerase eta (pol eta). However, residual A/T mutagenesis is still observe...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse.
Author(s) :
Delbos, Frédéric
,
De Smet, Annie
,
Faili, Ahmad
,
Aoufouchi, Said
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase eta, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.
Author(s) :
Gueranger, Quentin
,
Stary, Anne
,
Aoufouchi, Saïd
,
Faili, Ahmad
,
Sarasin, Alain
,
Reynaud, Claude-Agnès
,
Weill, Jean-Claude
Description :
Genes coding for DNA polymerases eta, iota and zeta, or for both Pol eta and Pol iota have been inactivated by homologous recombination in the Burkitt's lymphoma BL2 cell line, thus providing for the first time the total suppression of these enzymes in a human context. The UV sensitivities and UV-in...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
Proteasomal degradation restricts the nuclear lifespan of AID
Author(s) :
Aoufouchi, Said
,
Faili, Ahmad
,
Zober, Carole
,
D'Orlando, Orietta
,
Weller, Sandra
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig) locus. As uncontrolled expression of AID is potentially mutagenic, different types of regulation, particu...
Repository :
Europe PubMed Central
Language(s) :
English
Two novel human and mouse DNA polymerases of the polX family
Author(s) :
Aoufouchi, Said
,
Flatter, Eric
,
Dahan, Auriel
,
Faili, Ahmad
,
Bertocci, Barbara
,
Storck, Sebastien
,
Delbos, Frédéric
Description :
We describe here two novel mouse and human DNA polymerases: one (pol λ) has homology with DNA polymerase β while the other one (pol µ) is closer to terminal deoxynucleotidyltransferase. However both have DNA polymerase activity in vitro and share similar structural organization, including a BRCT dom...
Repository :
Europe PubMed Central
Language(s) :
English
DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination
Author(s) :
Faili, Ahmad
,
Aoufouchi, Said
,
Weller, Sandra
,
Vuillier, Françoise
,
Stary, Anne
,
Sarasin, Alain
,
Reynaud, Claude-Agnès
Description :
Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the characteristics of the ones observed during V gen...
Repository :
Europe PubMed Central
Language(s) :
English
DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.
Author(s) :
Faili, Ahmad
,
Aoufouchi, Said
,
Weller, Sandra
,
Vuillier, Françoise
,
Stary, Anne
,
Sarasin, Alain
,
Reynaud, Claude-Agnès
Description :
Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the characteristics of the ones observed during V gen...
Repository :
HAL - Hyper Article on Line
Language(s) :
English