Results
author = "FENOGLIO, CHIARA"
Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population
Description :
Repository :
AIR - Archivio Istituzionale della Ricerca
Language(s) :
English
MicroRNAs as Active Players in the Pathogenesis of Multiple Sclerosis
Description :
MicroRNAs (miRNAs) are a recently discovered group of small noncoding RNAs that regulate gene expression post-transcriptionally. They are highly expressed in cells of the immune system, as well as in the central nervous system, and they are deregulated in various neurological disorders. Emerging evi...
Repository :
Europe PubMed Central
Language(s) :
English
A functional variant in ERAP1 predisposes to multiple sclerosis
Author(s) :
BIASIN, MARA
,
CLERICI, MARIO SALVATORE
,
ASSELTA, ROSANNA
,
GALIMBERTI, DANIELA
,
FENOGLIO, CHIARA
,
SCARPINI, ELIO ANGELO
Description :
Repository :
AIR - Archivio Istituzionale della Ricerca
Language(s) :
English
Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease
Author(s) :
SCARPINI, ELIO ANGELO
,
GALIMBERTI, DANIELA
,
BRESOLIN, NEREO
,
FENOGLIO, CHIARA
,
VENTURELLI, ELIANA
,
CORTINI, FRANCESCA
Description :
Repository :
AIR - Archivio Istituzionale della Ricerca
Language(s) :
English
Rs5848 Variant Influences GRN mRNA Levels in Brain and Peripheral Mononuclear Cells in Patients with Alzheimer’s Disease
Author(s) :
SCARPINI, ELIO ANGELO
,
GALIMBERTI, DANIELA
,
BRESOLIN, NEREO
,
FENOGLIO, CHIARA
,
VENTURELLI, ELIANA
,
SCALABRINI, DIEGO
Description :
Mutations in the progranulin gene (GRN), causative for Frontotemporal Lobar Degeneration with ubiquitin-immunoreactive neuronal inclusions (FTLD-U), could also be associated with Alzheimer's disease (AD). The influence of GRN genetic variability on susceptibility to AD and on expression levels in a ...
Repository :
AIR - Archivio Istituzionale della Ricerca
Language(s) :
English
Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition
Author(s) :
Kauwe, John S. K.
,
Cruchaga, Carlos
,
Mayo, Kevin
,
Fenoglio, Chiara
,
Bertelsen, Sarah
,
Nowotny, Petra
,
Galimberti, Daniela
Description :
There is substantial evidence that cerebrospinal fluid (CSF) levels of both Aβ42 and tau/ptau are promising biomarkers for Alzheimer's disease (AD). We show that both Aβ and tau exhibit more than 10-fold interindividual variation in CSF levels suggesting that these biomarkers may also be effectively...
Repository :
Europe PubMed Central
Language(s) :
English
Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
Author(s) :
Piccio, Laura
,
Buonsanti, Cecilia
,
Cella, Marina
,
Tassi, Ilaria
,
Schmidt, Robert E.
,
Fenoglio, Chiara
,
Rinker, John
Description :
Triggering receptor expressed on myeloid cells 2 (TREM-2) is a membrane-bound receptor expressed by microglia and macrophages. Engagement of TREM-2 on these cells has been reported to reduce inflammatory responses and, in microglial cells, to promote phagocytosis. TREM-2 function is critical within ...
Repository :
Europe PubMed Central
Language(s) :
English
APOE ε2 and ε4 influence the susceptibility for Alzheimer's disease but not other dementias
Author(s) :
Lovati, Carlo
,
Galimberti, Daniela
,
Albani, Diego
,
Bertora, Pierluigi
,
Venturelli, Eliana
,
Cislaghi, Giuliana
,
Guidi, Ilaria
Description :
Apolipoprotein E (APOE) genotype was determined in a population of patients with dementia, including 735 patients with Alzheimer's disease (AD), 75 with Frontotemporal Lobar Degeneration (FTLD), 97 with Vascular Dementia (VaD) and 40 with Lewy Body Dementia (LBD), as well as in 506 age- and gender-m...
Repository :
Europe PubMed Central
Language(s) :
English
A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis
Author(s) :
Guerini, Franca Rosa
,
Cagliani, Rachele
,
Forni, Diego
,
Agliardi, Cristina
,
Caputo, Domenico
,
Cassinotti, Andrea
Description :
The ERAP1 gene encodes an aminopeptidase involved in antigen processing. A functional polymorphism in the gene (rs30187, Arg528Lys) associates with susceptibility to ankylosying spondylitis (AS), whereas a SNP in the interacting ERAP2 gene increases susceptibility to another inflammatory autoimmune ...
Repository :
Europe PubMed Central
Language(s) :
English
Progranulin Gene Variability and Plasma Levels in Bipolar Disorder and Schizophrenia
Author(s) :
Galimberti, Daniela
,
Dell'Osso, Bernardo
,
Fenoglio, Chiara
,
Villa, Chiara
,
Cortini, Francesca
,
Serpente, Maria
Description :
Basing on the assumption that frontotemporal lobar degeneration (FTLD), schizophrenia and bipolar disorder (BPD) might share common aetiological mechanisms, we analyzed genetic variation in the FTLD risk gene progranulin (GRN) in a German population of patients with schizophrenia (n = 271) or BPD (n...
Repository :
Europe PubMed Central
Language(s) :
English