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author = "Eling, T E"
1
Found 9 documents, displaying page 1 of 1
Metabolism of aromatic amines by prostaglandin H synthase.
Description :
The metabolism of aromatic amines by the peroxidase activity of prostaglandin H synthase (PHS) has been studied in this laboratory by use of two model compounds, the carcinogenic primary amine 2-aminofluorene (2-AF) and the substituted amine aminopyrine (AP). 2-AF is oxidized by PHS to 2, 2-azobisfl...
Repository :
Europe PubMed Central
Language(s) :
English
Pulmonary biosynthesis and metabolism of prostaglandins and related substances.
Description :
On passage through the lung vascular bed, prostaglandins are removed from the circulation by a transport carrier and subsequently inactivated by intracellular enzymes. However, PGI2 is not inactivated by the lung in vivo. Although PGI2 is an excellent substrate for the intracellular enzymes in vitro...
Repository :
Europe PubMed Central
Language(s) :
English
Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1/GDF15) Expression Is Increased by the Histone Deacetylase Inhibitor Trichostatin A*
Description :
Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is a
putative tumor suppressor whose expression can be increased by drug treatment.
Glioblastoma is the most common central nervous system tumor, is associated
with high morbidity and mortality, and responds poorly to surgical, chemical,
...
Repository :
Europe PubMed Central
Language(s) :
English
Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung
Description :
The isolated perfused lung is a valuable tool for studying many lung functions. The kinds of information one can obtain from the isolated perfused lung are illustrated by examples from our studies on the uptake, accumulation, and metabolism of endogenous and exogenous chemicals.
Repository :
Europe PubMed Central
Language(s) :
English
Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages.
Description :
Prostaglandin E2 is observed at elevated levels during human immunodeficiency virus (HIV) infection and thus may contribute to the HIV-dependent immunosuppression. The mechanisms responsible for this increase are not understood. Evidence indicates that the viral envelope proteins perturb membrane si...
Repository :
Europe PubMed Central
Language(s) :
English
Epoxidation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: activation of a procarcinogen by a cocarcinogen.
Description :
The (bi)sulfite ion undergoes extensive autoxidation in neutral aqueous media with the formation of sulfur trioxide radical anion that is detected by ESR. The radical anion subsequently reacts with molecular oxygen to form a peroxyl radical. We find that when (+/-)-trans-7,8-dihydroxy-7,8-dihydroben...
Repository :
Europe PubMed Central
Language(s) :
English
Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice
Author(s) :
Matsuoka, T
,
Adair, J E
,
Lih, F B
,
Hsi, L C
,
Rubino, M
,
Eling, T E
,
Tomer, K B
,
Yashiro, M
,
Hirakawa, K
,
Olden, K
,
Roberts, J D
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Expression of Gab1 Lacking the Pleckstrin Homology Domain Is Associated with Neoplastic Progression
Author(s) :
Kameda, Hideto
,
Risinger, John I.
,
Han, Bing-Bing
,
Baek, Seung Joon
,
Barrett, J. Carl
,
Abe, Tohru
,
Takeuchi, Tsutomu
Description :
An in vitro transformation system of carcinogen-treated Syrian hamster embryo (SHE) cell cultures represents multistep genetic and nongenetic changes that develop during the neoplastic progression of normal cells to tumor cells in vivo. During this neoplastic progression, SHE cells demonstrate an al...
Repository :
Europe PubMed Central
Language(s) :
English
A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L
Author(s) :
Malathi, Krishnamurthy
,
Paranjape, Jayashree M.
,
Bulanova, Elena
,
Shim, Minsub
,
Guenther-Johnson, Jeanna M.
,
Faber, Pieter W.
Description :
Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2′-5′ oligoadenylate synthetases. 2′-5′ oligoadenylate synthetase is stimulated by dsRNA to produce 5′-phosphorylated, 2′-5′-linked oligoadenylates (2-5A), whose fu...
Repository :
Europe PubMed Central
Language(s) :
English
1
Found 9 documents, displaying page 1 of 1