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author = "Dr Jun-yong Huang"
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Found 5 documents, displaying page 1 of 1

The dynamic localisation of the iDrosophilai APCC evidence for the existence of multiple complexes that perform distinct functions and are differentially localised

Author(s) : Dr Jun-yong Huang
Description : In Drosophila cells the destruction of cyclin B is spatially regulated. In cellularised embryos cyclin B is initially degraded on the mitotic spindle and is then degraded in the cytoplasm. In syncytial embryos only the spindle-associated cyclin B is degraded at the end of mitosis. The anaphase promo...
Repository : University of Newcastle Library E-Print Archives
Language(s) : English

The roles of FzyCdc20 and FzrCdh1 in regulating the destruction of cyclin B in space and time

Author(s) : Dr Jun-yong Huang
Description : In Drosophila cells cyclin B is normally degraded in two phases a destruction of the spindle-associated cyclin B initiates at centrosomes and spreads to the spindle equator and b any remaining cytoplasmic cyclin B is degraded slightly later in mitosis. We show that the APCC regulators Fizzy FzyCdc20...
Repository : University of Newcastle Library E-Print Archives
Language(s) : English

Recruitment of Mad2 to the Kinetochore Requires the RodZw10 Complex

Author(s) : Dr Jun-yong Huang
Description : The spindle assembly or metaphase checkpoint is crucial to the proper segregation of chromosomes by the mitotic apparatus in all eukaryotes. The checkpoint mechanism in metazoans is more complex than that of yeast and requires additional proteins and activities besides the six classical Mads and Bub...
Repository : University of Newcastle Library E-Print Archives
Language(s) : English

Cdk1 phosphorylation sites on Cdc27 are required for correct chromosomal localisation and APCC function in syncytial Drosophila embryos

Author(s) : G Morley , D Li , Dr Jun-yong Huang , Prof. Michael John Whitaker
Description : Anaphase-promoting complex or cyclosome APCC controls the metaphase-to-anaphase transition and mitosis exit by triggering the degradation of key cell cycle regulators such as securin and B-type cyclins. However little is known about the functions of individual APCC subunits and how they might regula...
Repository : University of Newcastle Library E-Print Archives
Language(s) : English

ERK1 activation is required for S-phase onset and cell cycle progression after fertilization in sea urchin embryos

Author(s) : Prof. Michael John Whitaker , Dr Jun-yong Huang
Description : Fertilization of sea urchin eggs results in a large transient increase in intracellular free Ca2 concentration that is responsible for re-initiation of the cell division cycle. We show that activation of ERK1 a Ca2-dependent MAP kinase response is required for both DNA synthesis and cell cycle progr...
Repository : University of Newcastle Library E-Print Archives
Language(s) : English
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Found 5 documents, displaying page 1 of 1