Results
author = "Dey, Sudhansu K."
How we are born
Author(s) :
Dey, Sudhansu K.
Description :
Human reproduction is relatively inefficient. Nearly 30% of pregnancies result in spontaneous losses, which are both a clinical problem and a psychological stress to the families involved. Furthermore, although the human population is growing rapidly and is predicted to reach 9 billion by 2050, 15% ...
Repository :
Europe PubMed Central
Language(s) :
English
Pandora’s baby: How the first test tube babies sparked the reproductive revolution
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Loss of Cannabinoid Receptor CB1 Induces Preterm Birth
Description :
Repository :
Europe PubMed Central
Language(s) :
English
In Pursuit of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor-5 Regulation and Function in the Uterus
Description :
Leucine-rich repeat-containing G protein-coupled receptor (LGR)-5 is a recently identified marker of stem cells in adult intestinal epithelium and hair follicles. Because of this characteristic, we studied the status of Lgr5 expression in the mouse uterus under various conditions. Lgr5 is highly exp...
Repository :
Europe PubMed Central
Language(s) :
English
Endocannabinoid signaling directs periimplantation events
Description :
An emerging concept in female reproduction is the role of endocannabinoids, a group of endogenously produced lipid mediators that bind to and activate cannabinoid receptors. Although adverse effects of cannabinoids in female reproduction have been implicated for years, the mechanisms by which they e...
Repository :
Europe PubMed Central
Language(s) :
English
MicroRNA regulation of cyclooxygenase-2 during embryo implantation
Author(s) :
Chakrabarty, Anindita
,
Tranguch, Susanne
,
Daikoku, Takiko
,
Jensen, Kevin
,
Furneaux, Henry
,
Dey, Sudhansu K.
Description :
The implantation process is complex, requiring reciprocal interactions between implantation-competent blastocysts and the receptive uterus. Because microRNAs (miRNAs) have major roles in regulating gene expression, we speculated that they participate in directing the highly regulated spatiotemporall...
Repository :
Europe PubMed Central
Language(s) :
English
Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
Description :
Although preterm delivery is a major global health issue, its causes and underlying mechanism remain elusive. Using mutant mice, mimicking aspects of human preterm birth, we show here that uterine decidual senescence early in pregnancy via heightened mammalian target of rapamycin complex 1 (mTORC1) ...
Repository :
Europe PubMed Central
Language(s) :
English
Coordinated regulation of fetal and maternal prostaglandins directs successful birth and postnatal adaptation in the mouse
Author(s) :
Reese, Jeff
,
Paria, Bibhash C.
,
Brown, Naoko
,
Zhao, Xuemei
,
Morrow, Jason D.
,
Dey, Sudhansu K.
Description :
Cyclooxygenase (COX)-derived prostaglandins (PGs) regulate numerous maternal–fetal interactions during pregnancy. PGs stimulate uterine contractions and prepare the cervix for parturition, whereas in the fetus, PGs maintain patency of the ductus arteriosus (DA), a vascular shunt that transmits oxyge...
Repository :
Europe PubMed Central
Language(s) :
English
Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation
Description :
Many underlying causes of human infertility have been overcome by using in vitro fertilization (IVF) and embryo transfer (ET) techniques. Nevertheless, implantation rates in IVF programs remain low despite the transfer of apparently healthy embryos. This suggests that there are problems with the dif...
Repository :
Europe PubMed Central
Language(s) :
English
Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation
Author(s) :
Wang, Haibin
,
Matsumoto, Hiromichi
,
Guo, Yong
,
Paria, Bibhash C.
,
Roberts, Richard L.
,
Dey, Sudhansu K.
Description :
Mammalian fertility absolutely depends on synchronized development of the blastocyst to the stage when it is competent to implant, and the uterus to the stage when it is receptive to implantation. However, the molecular basis for the reciprocal interaction between the embryo and the uterus remains l...
Repository :
Europe PubMed Central
Language(s) :
English