Results
author = "Dey, Sudhansu K."
Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer
Author(s) :
Gupta, Rajnish A.
,
Tan, Jian
,
Krause, Wade F.
,
Geraci, Mark W.
,
Willson, Timothy M.
,
Dey, Sudhansu K.
,
DuBois, Raymond N.
Description :
There is evidence from both genetic and pharmacologic studies
to suggest that the cyclooxygenase-2 (COX-2) enzyme plays a causal role
in the development of colorectal cancer. However, little is known about
the identity or role of the eicosanoid receptor pathways activated by
COX-derived prostagl...
Repository :
Europe PubMed Central
Language(s) :
English
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
Author(s) :
Brisken, Cathrin
,
Heineman, Anna
,
Chavarria, Tony
,
Elenbaas, Brian
,
Tan, Jian
,
Dey, Sudhansu K.
,
McMahon, Jill A.
Description :
Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome this defect by ectopic expression of the protooncogene Wnt-1. Transplantation of mammary epithelia fro...
Repository :
Europe PubMed Central
Language(s) :
English
Crosstalk between peroxisome proliferator-activated receptor δ and VEGF stimulates cancer progression
Author(s) :
Wang, Dingzhi
,
Wang, Haibin
,
Guo, Yong
,
Ning, Wei
,
Katkuri, Sharada
,
Wahli, Walter
,
Desvergne, Beatrice
,
Dey, Sudhansu K.
Description :
Peroxisome proliferator-activated receptor (PPAR) δ is a member of the nuclear hormone receptor superfamily. PPARδ may ameliorate metabolic diseases such as obesity and diabetes. However, PPARδ's role in colorectal carcinogenesis remains controversial. Here, we present genetic and pharmacologic evid...
Repository :
Europe PubMed Central
Language(s) :
English
Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors
Author(s) :
Anning, Peter B.
,
Coles, Barbara
,
Morton, Jonathan
,
Wang, Haibin
,
Uddin, Jashim
,
Morrow, Jason D.
,
Dey, Sudhansu K.
Description :
The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by NSAIDs are unknown. Because patients with arthritis have decreased nitric oxide (NO) bioavailability, t...
Repository :
Europe PubMed Central
Language(s) :
English
COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation
Author(s) :
Ghosh, Mallika
,
Wang, Haibin
,
Ai, Youxi
,
Romeo, Elisa
,
Luyendyk, James P.
,
Peters, Jeffrey M.
,
Mackman, Nigel
,
Dey, Sudhansu K.
Description :
Although cyclooxygenase (COX)-2 inhibitors (coxibs) are effective in controlling inflammation, pain, and tumorigenesis, their use is limited by the recent revelation of increased adverse cardiovascular events. The mechanistic basis of this side effect is not well understood. We show that the metabol...
Repository :
Europe PubMed Central
Language(s) :
English
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
Author(s) :
Wang, Dingzhi
,
Wang, Haibin
,
Brown, Joanne
,
Daikoku, Takiko
,
Ning, Wei
,
Shi, Qiong
,
Richmond, Ann
,
Strieter, Robert
Description :
Chronic inflammation is a well-known risk factor for cancer. Proinflammatory mediators such as prostaglandin E2 (PGE2) promote colorectal tumor growth by stimulating angiogenesis, cell invasion, and cell growth, and inhibiting apoptosis. Molecules that regulate tumor-associated angiogenesis provide ...
Repository :
Europe PubMed Central
Language(s) :
English
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
Author(s) :
Tranguch, Susanne
,
Cheung-Flynn, Joyce
,
Daikoku, Takiko
,
Prapapanich, Viravan
,
Cox, Marc B.
,
Xie, Huirong
,
Wang, Haibin
Description :
Embryo implantation in the uterus is a critical step in mammalian reproduction, requiring preparation of the uterus receptive to blastocyst implantation. Uterine receptivity, also known as the window of implantation, lasts for a limited period, and it is during this period blastocysts normally impla...
Repository :
Europe PubMed Central
Language(s) :
English
Fatty acid amide hydrolase deficiency limits early pregnancy events
Author(s) :
Wang, Haibin
,
Xie, Huirong
,
Guo, Yong
,
Zhang, Hao
,
Takahashi, Toshifumi
,
Kingsley, Philip J.
,
Marnett, Lawrence J.
Description :
Synchronized preimplantation embryo development and passage through the oviduct into the uterus are prerequisites for implantation, dysregulation of which often leads to pregnancy failure in women. Cannabinoid/endocannabinoid signaling via cannabinoid receptor CB1 is known to influence early pregnan...
Repository :
Europe PubMed Central
Language(s) :
English
Maternal heparin-binding-EGF deficiency limits pregnancy success in mice
Author(s) :
Xie, Huirong
,
Wang, Haibin
,
Tranguch, Susanne
,
Iwamoto, Ryo
,
Mekada, Eisuke
,
DeMayo, Francesco J.
,
Lydon, John P.
Description :
An intimate discourse between the blastocyst and uterus is essential for successful implantation. However, the molecular basis of this interaction is not clearly understood. Exploiting genomic Hbegf mutant mice, we show here that maternal deficiency of heparin-binding EGF-like growth factor (HB-EGF)...
Repository :
Europe PubMed Central
Language(s) :
English
Genetic Loss of Faah Compromises Male Fertility in Mice1
Author(s) :
Sun, Xiaofei
,
Wang, Haibin
,
Okabe, Masaru
,
Mackie, Kenneth
,
Kingsley, Philip J.
,
Marnett, Lawrence J.
,
Cravatt, Benjamin F.
Description :
Marijuana is the most commonly used illicit drug. Although there is some indication that reproductive functions in males are impaired in chronic marijuana users, the genetic evidence and underlying causes remain largely unknown. Herein we show that genetic loss of Faah, which encodes fatty acid amid...
Repository :
Europe PubMed Central
Language(s) :
English