Results
author = "Delattre, Olivier"
EWS/FLI-1 Silencing and Gene Profiling of Ewing Cells Reveal Downstream Oncogenic Pathways and a Crucial Role for Repression of Insulin-Like Growth Factor Binding Protein 3†
Description :
Ewing tumors are characterized by abnormal transcription factors resulting from the oncogenic fusion of EWS with members of the ETS family, most commonly FLI-1. RNA interference targeted to the junction between EWS and FLI-1 sequences was used to inactivate the EWS/FLI-1 fusion gene in Ewing cells a...
Repository :
Europe PubMed Central
Language(s) :
English
RFLP identified by the anonymous DNA segment FZ V D11 at 22q13 [HGM9 no.D22S80]
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Do host species evolve a specific response to slave-making ants?
Author(s) :
Delattre Olivier
,
Blatrix Rumsaïs
,
Châline Nicolas
,
Chameron Stéphane
,
Fédou Anne
,
Leroy Chloé
,
Jaisson Pierre
Description :
Abstract
Background
Social parasitism is an important selective pressure for social insect species. It is particularly the case for the hosts of dulotic (so called slave-making) ants, which pillage the brood of host colonies to increase the worker force of their own colony. Such rai...
Repository :
DOAJ-Articles
Language(s) :
English
Localizing potentially active post-transcriptional regulations in the Ewing's sarcoma gene regulatory network
Author(s) :
Baumuratova Tatiana
,
Surdez Didier
,
Delyon Bernard
,
Stoll Gautier
,
Delattre Olivier
,
Radulescu Ovidiu
,
Siegel Anne
Description :
Abstract
Background
A wide range of techniques is now available for analyzing regulatory networks. Nonetheless, most of these techniques fail to interpret large-scale transcriptional data at the post-translational level.
Results
We address the question of using large-s...
Repository :
DOAJ-Articles
Language(s) :
English
NOTCH2 Is Neither Rearranged nor Mutated in t(1;19) Positive Oligodendrogliomas
Author(s) :
Benetkiewicz, Magdalena
,
Idbaih, Ahmed
,
Cousin, Pierre-Yves
,
Boisselier, Blandine
,
Marie, Yannick
,
Crinière, Emmanuelle
Description :
The combined deletion of 1p and 19q chromosomal arms is frequent in oligodendrogliomas (OD) and has recently been shown to be mediated by an unbalanced t(1;19) translocation. Recent studies of 1p/19q co-deleted OD suggest that the NOTCH2 gene is implicated in oligodendrocyte differentiation and may ...
Repository :
Europe PubMed Central
Language(s) :
English
The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function
Author(s) :
Guillon, Noëlle
,
Tirode, Franck
,
Boeva, Valentina
,
Zynovyev, Andrei
,
Barillot, Emmanuel
,
Delattre, Olivier
Description :
The fusion between EWS and ETS family members is a key oncogenic event in Ewing tumors and important EWS-FLI1 target genes have been identified. However, until now, the search for EWS-FLI1 targets has been limited to promoter regions and no genome-wide comprehensive analysis of in vivo EWS-FLI1 bind...
Repository :
Europe PubMed Central
Language(s) :
English
EWS, but Not EWS-FLI-1, Is Associated with Both TFIID and RNA Polymerase II: Interactions between Two Members of the TET Family, EWS and hTAFII68, and Subunits of TFIID and RNA Polymerase II Complexes
Author(s) :
Bertolotti, Anne
,
Melot, Thomas
,
Acker, Joël
,
Vigneron, Marc
,
Delattre, Olivier
,
Tora, Laszlo
Description :
The t(11;22) chromosomal translocation specifically linked to Ewing sarcoma and primitive neuroectodermal tumor results in a chimeric molecule fusing the amino-terminus-encoding region of the EWS gene to the carboxyl-terminal DNA-binding domain encoded by the FLI-1 gene. As the function of the prote...
Repository :
Europe PubMed Central
Language(s) :
English
Constitutional Mutations of the hSNF5/INI1 Gene Predispose to a Variety of Cancers
Author(s) :
Sévenet, Nicolas
,
Sheridan, Eammon
,
Amram, Daniel
,
Schneider, Pascale
,
Handgretinger, Rupert
,
Delattre, Olivier
Description :
Biallelic, truncating mutations of the hSNF5/INI1 gene have recently been documented in malignant rhabdoid tumor (MRT), one of the most aggressive human cancers. This finding suggests that hSNF5/INI1 is a new tumor-suppressor gene for which germline mutations might predispose to cancer. We now repor...
Repository :
Europe PubMed Central
Language(s) :
English
Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer
Author(s) :
Sanchez, Gabriel
,
Bittencourt, Danielle
,
Laud, Karine
,
Barbier, Jérôme
,
Delattre, Olivier
,
Auboeuf, Didier
,
Dutertre, Martin
Description :
Pre-mRNA splicing and polyadenylation are tightly connected to transcription, and transcriptional stimuli and elongation dynamics can affect mRNA maturation. However, whether this regulatory mechanism has a physio/pathological impact is not known. In cancer, where splice variant expression is often ...
Repository :
Europe PubMed Central
Language(s) :
English
De novo motif identification improves the accuracy of predicting transcription factor binding sites in ChIP-Seq data analysis
Author(s) :
Boeva, Valentina
,
Surdez, Didier
,
Guillon, Noëlle
,
Tirode, Franck
,
Fejes, Anthony P.
,
Delattre, Olivier
,
Barillot, Emmanuel
Description :
Dramatic progress in the development of next-generation sequencing technologies has enabled accurate genome-wide characterization of the binding sites of DNA-associated proteins. This technique, baptized as ChIP-Seq, uses a combination of chromatin immunoprecipitation and massively parallel DNA sequ...
Repository :
Europe PubMed Central
Language(s) :
English