Results
author = "Deisseroth, A"
Astrocytes Control Breathing Through pH-Dependent Release of ATP
Author(s) :
Gourine, AV
,
Kasymov, V
,
Marina, N
,
Tang, FG
,
Figueiredo, MF
,
Lane, S
,
Teschemacher, AG
,
Spyer, KM
,
Deisseroth, K
,
Kasparov, S
Description :
Astrocytes provide structural and metabolic support for neuronal networks, but direct evidence demonstrating their active role in complex behaviors is limited. Central respiratory chemosensitivity is an essential mechanism that, via regulation of breathing, maintains constant levels of blood and bra...
Repository :
UCL Eprints
Language(s) :
Undetermined
Calmodulin priming: Nuclear translocation of a calmodulin complex and the memory of prior neuronal activity
Author(s) :
Mermelstein, Paul G.
,
Deisseroth, Karl
,
Dasgupta, Neela
,
Isaksen, Ann L.
,
Tsien, Richard W.
Description :
The neuronal nucleus plays a vital role in information
processing, but whether it supports computational functions such as
paired-pulse facilitation, comparable to synapses, is unclear.
Ca2+-dependent movement of calmodulin (CaM) to
the nucleus is highly responsive to Ca2+ entry through
L-type ...
Repository :
Europe PubMed Central
Language(s) :
English
A phosphatase activity present in peripheral blood myeloid cells of chronic myelogenous leukemia patients but not normal individuals alters nuclear protein binding to transcriptional enhancers of interferon-inducible genes.
Author(s) :
Seong, D C
,
Sims, S
,
Johnson, E
,
Howard, O M
,
Reiter, B
,
Hester, J
,
Talpaz, M
,
Kantarjian, H
,
Deisseroth, A
Description :
Cytoplasmic protein from peripheral blood myeloid cells of chronic myelogenous leukemia (CML) patients altered the electrophoretic mobility of complexes formed between nuclear proteins and interferon-inducible transcriptional enhancers. Immature myeloid marrow cells (blasts and promyelocytes) have a...
Repository :
Europe PubMed Central
Language(s) :
English
Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells.
Author(s) :
Upadhyaya, G
,
Guba, S C
,
Sih, S A
,
Feinberg, A P
,
Talpaz, M
,
Kantarjian, H M
,
Deisseroth, A B
,
Emerson, S G
Description :
Hematopoietic cells from the malignant clone in chronic myelogenous leukemia (CML) maintain and expand a proliferative advantage over normal hematopoietic cells within the bone marrow. This advantage is often ameliorated or reversed in vivo by IFN alpha. Based upon earlier studies suggesting decreas...
Repository :
Europe PubMed Central
Language(s) :
English
A temperature-sensitive mutant of human p53.
Description :
We discovered that the human 'hot-spot' p53 mutant 143Ala is temperature sensitive for the binding of two DNA elements and for mediating the transcription of a downstream luciferase reporter gene. At 32.5 degrees C, 143Ala possesses strong DNA binding ability. In addition, its transcriptional activi...
Repository :
Europe PubMed Central
Language(s) :
English
Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes.
Author(s) :
Anagnou, N P
,
Ley, T J
,
Chesbro, B
,
Wright, G
,
Kitchens, C
,
Liebhaber, S
,
Nienhuis, A W
,
Deisseroth, A B
Description :
A somatic mutation(s), acquired during the evolution of preleukemia in a 75-year-old Caucasian male of North European origin, resulted in a marked decrease in alpha-globin mRNA. The small amount of alpha-globin mRNA present in bone marrow cells was normally processed, had a normal (alpha 1/alpha 2)-...
Repository :
Europe PubMed Central
Language(s) :
English
An adenoviral vector cancer vaccine that delivers a tumor-associated antigen/CD40-ligand fusion protein to dendritic cells
Author(s) :
Zhang, Lixin
,
Tang, Yucheng
,
Akbulut, Hakan
,
Zelterman, Daniel
,
Linton, Phyllis-Jean
,
Deisseroth, Albert B.
Description :
To develop a method to overcome the anergy that exists in tumor hosts to cancer, we have designed an adenoviral vector for the in vivo activation and tumor antigen loading of dendritic cells. This adenoviral vector encodes a fusion protein composed of an amino-terminal tumor-associated antigen fragm...
Repository :
Europe PubMed Central
Language(s) :
English
High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels
Author(s) :
Berndt, André
,
Schoenenberger, Philipp
,
Mattis, Joanna
,
Tye, Kay M.
,
Deisseroth, Karl
,
Hegemann, Peter
,
Oertner, Thomas G.
Description :
Channelrhodopsin-2 (ChR2) has become an indispensable tool in neuroscience, allowing precise induction of action potentials with short light pulses. A limiting factor for many optophysiological experiments is the relatively small photocurrent induced by ChR2. We screened a large number of ChR2 point...
Repository :
Europe PubMed Central
Language(s) :
English
Multiscale Computational Models for Optogenetic Control of Cardiac Function
Author(s) :
Abilez, Oscar J.
,
Wong, Jonathan
,
Prakash, Rohit
,
Deisseroth, Karl
,
Zarins, Christopher K.
,
Kuhl, Ellen
Description :
The ability to stimulate mammalian cells with light has significantly changed our understanding of electrically excitable tissues in health and disease, paving the way toward various novel therapeutic applications. Here, we demonstrate the potential of optogenetic control in cardiac cells using a hy...
Repository :
Europe PubMed Central
Language(s) :
English
Structural Model of Channelrhodopsin*
Author(s) :
Watanabe, Hiroshi C.
,
Welke, Kai
,
Schneider, Franziska
,
Tsunoda, Satoshi
,
Zhang, Feng
,
Deisseroth, Karl
,
Hegemann, Peter
Description :
Background: The channelrhodopsins are widely used for optogenetic application, whereas a structural model was not available before now.
Repository :
Europe PubMed Central
Language(s) :
English