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author = "De Tullio, Pascal"
1
Found 10 documents, displaying page 4 of 1
Le noyau arylthiadiazine 1,1-dioxyde en chimie médicinale : développements originaux de composés à potentialités thérapeutiques
Author(s) :
De Tullio, Pascal
Description :
Repository :
ORBi (University of Liège)
Language(s) :
French
MEASURING VARIABILITY SOURCES IN NMR METABOLOMIC STUDIES
Description :
Due to the huge amount of information available in NMR spectra obtained from the analysis of metabolomic experiments, multivariate analysis such as Principal Component Analysis (PCA) are required to understand the influence of treatments over the metabolites [1]. However, many experiments in metabo...
Repository :
ORBi (University of Liège)
Language(s) :
English
K-ATP channel openers: Tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1-dioxides
Author(s) :
Lebrun, Philippe
,
Becker, Benedicte
,
Morel, Nicole
,
Ghisdal, Philippe
,
Antoine, Marie-Helene
,
de Tullio, Pascal
Description :
The present study was designed to further evaluate the biological effects and tissue selectivity of new 3-alkylaminobenzo-and 3-alkylaminopyridothiadiazine 1,1-dioxides bearing identical branched alkylamino chains at the 3-position. These original compounds were compared with their parent molecules;...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Advantages of the Bagidis methodology for metabonomics analyses: application to a spectroscopic study of Age-related Macular Degeneration
Author(s) :
Timmermans, Catherine
,
de Tullio, Pascal
,
Lambert, Vincent
,
Frédérich, Michel
,
Rousseau, Réjane
,
von Sachs, Rainer
Description :
The Bagidis methodology proposes a distance measure between spectra, that takes into account, in a unified framework, both horizontal shifts and amplitudes variations that might affect spectral peaks. The method relies on the expansion of the spectra in unbalanced Haar wavelet bases. Its opportunity...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.
Author(s) :
Goffin, Eric
,
Lamoral-Theys, Delphine
,
Tajeddine, Nicolas
,
De Tullio, Pascal
,
Mondin, Ludivine
,
Lefranc, Florence
Description :
A series of chroman derivatives previously reported as potassium channel openers, as well as some newly synthesized simplified structures, were examined for their in vitro effects on the growth of three human high-grade glioma cell lines: U373, T98G, and Hs683. Significant in vitro growth inhibitory...
Repository :
ORBi (University of Liège)
Language(s) :
English
Development of a mass spectrometry method for the determination of a melanoma biomarker, 5-S-cysteinyldopa, in human plasma using solid phase extraction for sample clean-up.
Author(s) :
Martin, Gaëlle
,
Chiap, Patrice
,
Paquet, Philippe
,
Pierard, Gérald
,
De Tullio, Pascal
,
Martin, Yves
,
Rozet, Eric
,
Hubert, Philippe
Description :
5-S-cysteinyldopa is a well-known pigment intermediate and analysis of its plasma concentration is interesting for the early diagnosis, as well as for evaluation of treatment and follow-up of malignant melanoma. A determination method of 5-SCD in human plasma was developed using solid phase extracti...
Repository :
ORBi (University of Liège)
Language(s) :
English
6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis
Author(s) :
Kempen, I.
,
Hemmer, Marc
,
Counerotte, Stéphane
,
Pochet, L.
,
De Tullio, Pascal
,
Foidart, Jean-Michel
,
Blacher, Silvia
Description :
Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new a...
Repository :
ORBi (University of Liège)
Language(s) :
English
New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors
Author(s) :
Francotte, Pierre
,
Goffin, Eric
,
Fraikin, Pierre
,
Lestage, Pierre
,
Van Heugen, Jean-Claude
,
Gillotin, Florian
,
Danober, Laurence
Description :
In the search of a potent cognitive enhancer, a series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides have been synthesized and evaluated as positive allosteric modulators of the AMPA receptors. In the present work, we focused our efforts on the insertion of mono- or polyfluoro- substituted a...
Repository :
ORBi (University of Liège)
Language(s) :
English
BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic b-cells
Author(s) :
Lee, A. T.
,
Cosgrove, K. E.
,
Barnes, P. D.
,
Lindley, K. J.
,
Aynsley-Green, A.
,
De Tullio, Pascal
,
Pirotte, Bernard
Description :
Repository :
ORBi (University of Liège)
Language(s) :
English
New Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent
Author(s) :
Hemmer, M.
,
Kempen, Isabelle
,
De Tullio, Pascal
,
Frankenne, Francis
,
Lambert, Vincent
,
Blacher, Silvia
,
Bueb, Jean-Luc
Description :
The development of blood vessels inside tumors is required to provide the nutrients and
oxygen needed for tumor growth and to allow the spread of cancer cells at a distance to form metastasis. Angiogenesis is also implicated in ocular diseases like age-related macular degeneration. The present work ...
Repository :
ORBi (University of Liège)
Language(s) :
English
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Found 10 documents, displaying page 4 of 1