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author = "Daidone, M. G."
1
Found 10 documents, displaying page 1 of 1
Expression of high-affinity 67-kDa laminin receptors in primary breast cancers and metachronous metastatic lesions or contralateral cancers.
Description :
The presence of high-affinity 67-kDa laminin receptors, detected immunohistochemically, was determined on 63 primary breast cancers and on metachronous metastatic lesions or contralateral cancers from the same patients. A disagreement was observed in two-thirds of the cases. In particular, laminin r...
Repository :
Europe PubMed Central
Language(s) :
English
Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationships among markers related to angiogenesis and hormone dependence
Description :
To obtain a more integrated understanding of the different breast cancer phenotypes and to investigate whether bio-molecular profiles can distinguish between specific histotypes, we explored the interrelations among several biologic variables indicative of, or related to, hormone dependence, prolife...
Repository :
Europe PubMed Central
Language(s) :
English
Involvement of bcl-2 and p21waf1 proteins in response of human breast cancer cell clones to Tomudex
Description :
Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We ...
Repository :
Europe PubMed Central
Language(s) :
English
High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma
Description :
Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The ALT pathway is more commonly activated in tumours of mesenchymal origin, although the mechanisms involved in the decision of a cell to activate either telomerase or ALT ...
Repository :
Europe PubMed Central
Language(s) :
English
Biomarkers and outcome after tamoxifen treatment in node-positive breast cancers from elderly women
Author(s) :
Daidone, M G
,
Luisi, A
,
Martelli, G
,
Benini, E
,
Veneroni, S
,
Tomasic, G
,
De Palo, G
,
Silvestrini, R
Description :
The predictive role of tumour proliferative rate and expression of p53, bcl-2 and bax proteins, alone and in association with tumour size, nodal involvement and oestrogen receptors (ER), was analysed on 145 elderly patients (≥70 years of age) with histologically assessed node-positive breast cancers...
Repository :
Europe PubMed Central
Language(s) :
English
Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions
Author(s) :
Colella, G
,
Pennati, M
,
Bearzatto, A
,
Leone, R
,
Colangelo, D
,
Manzotti, C
,
Daidone, M G
,
Zaffaroni, N
Description :
A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin. Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental fo...
Repository :
Europe PubMed Central
Language(s) :
English
Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer
Author(s) :
Paradiso, A
,
Simone, G
,
Lena, M De
,
Leone, B
,
Vallejo, C
,
Lacava, J
,
Dellapasqua, S
,
Daidone, M G
,
Costa, A
Description :
The clinical relevance of bax and bcl-2 protein expression has been investigated in 84 patients with recurrent or metastatic colorectal cancer submitted to a chemotherapy regimen including methotrexate and fluorouracil/leucovorin. Cytoplasmic immunostaining of bax and bcl-2 was present in 65.5% and ...
Repository :
Europe PubMed Central
Language(s) :
English
Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation
Author(s) :
Lopergolo, A
,
Pennati, M
,
Gandellini, P
,
Orlotti, N I
,
Poma, P
,
Daidone, M G
,
Folini, M
,
Zaffaroni, N
Description :
We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted...
Repository :
Europe PubMed Central
Language(s) :
English
A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT
Author(s) :
Lafferty-Whyte, K
,
Cairney, C J
,
Will, M B
,
Serakinci, N
,
Daidone, M-G
,
Zaffaroni, N
,
Bilsland, A
,
Keith, W N
Description :
Udgivelsesdato: 2009-Oct-29
,
Telomere length is maintained by two known mechanisms, the activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and it is unknown how the decision of which pathway to activate is...
Repository :
Research at ASB
Language(s) :
English
Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen
Author(s) :
Coradini, D
,
Biganzoli, E
,
Pellizzaro, C
,
Veneroni, S
,
Oriana, S
,
Ambrogi, F
,
Erdas, R
,
Boracchi, P
,
Daidone, M G
,
Marubini, E
Description :
Repository :
Europe PubMed Central
Language(s) :
English
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Found 10 documents, displaying page 1 of 1