Results
author = "Cullingford, Timothy E."
1
Found 10 documents, displaying page 1 of 1
Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2
Author(s) :
Clerk, Angela
,
Cullingford, Timothy E.
,
Fuller, Stephen
,
Giraldo, Alejandro
,
Sugden, Peter
Description :
Repository :
CentAUR
Language(s) :
Undetermined
Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: Effects of endothelin-1, oxidative stress and cytokines
Author(s) :
Cullingford, Timothy E.
,
Butler, Matthew J.
,
Marshall, Andrew K.
,
Tham, El Li
,
Sugden, Peter H.
,
Clerk, Angela
Description :
Krüppel-like transcription factors (Klfs) modulate fundamental cell processes. Cardiac myocytes are terminally-differentiated, but hypertrophy in response to stimuli such as endothelin-1. H2O2 or cytokines promote myocyte apoptosis. Microarray studies of neonatal rat myocytes identified several Klfs...
Repository :
Europe PubMed Central
Language(s) :
English
ERK1/2 Signaling Dominates Over RhoA Signaling in Regulating Early Changes in RNA Expression Induced by Endothelin-1 in Neonatal Rat Cardiomyocytes
Author(s) :
Marshall, Andrew K.
,
Barrett, Oliver P. T.
,
Cullingford, Timothy E.
,
Shanmugasundram, Achchuthan
,
Sugden, Peter H.
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin
Author(s) :
Markou Thomais
,
Marshall Andrew K
,
Cullingford Timothy E
,
Tham El L
,
Sugden Peter H
,
Clerk Angela
Description :
Abstract
Background
Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein synthesis. Insulin also...
Repository :
DOAJ-Articles
Language(s) :
English
Gene expression profiling of human hibernating myocardium: Increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart
Author(s) :
Prasad, Sanjay K.
,
Clerk, Angela
,
Cullingford, Timothy E.
,
Chen, Alex W. Y.
,
Kemp, Timothy J.
,
Cannell, Timothy M.
Description :
A greater understanding of the molecular basis of hibernating myocardium may assist in identifying those patients who would most benefit from revascularization. Paired heart biopsies were taken from hypocontractile and normally-contracting myocardium (identified by cardiovascular magnetic resonance)...
Repository :
CentAUR
Language(s) :
Undetermined
Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors
Author(s) :
Fuller, Stephen John
,
Pikkarainen, Sampsa
,
Tham, El Li
,
Cullingford, Timothy E.
,
Molkentin, Jeff D.
,
Cornils, H
Description :
The nuclear Dbf2-related protein kinases 1 and 2 (NDR1/2) are closely-related AGC family kinases that are strongly conserved through evolution. In mammals, they are activated inter alia by phosphorylation of an hydrophobic domain threonine-residue [NDR1(Thr-444)/NDR2(Thr-442)] by an extrinsic protei...
Repository :
CentAUR
Language(s) :
Undetermined
Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition
Author(s) :
Markou, Thomais
,
Cullingford, Timothy E.
,
Giraldo Ramirez, Alejandro
,
Weiss, Sophie C.
,
Alsafi, Ali
,
Fuller, Stephen John
Description :
Inhibition of glycogen synthase kinase 3β (GSK3β) as a consequence of its phosphorylation by protein kinase B/Akt (PKB/Akt) has been implicated in cardiac myocyte hypertrophy in response to endothelin-1 or phenylephrine. We examined the regulation of GSK3α (which we show to constitute a significant ...
Repository :
CentAUR
Language(s) :
Undetermined
Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin
Author(s) :
Markou, Thomais
,
Marshall, Andrew K
,
Cullingford, Timothy E
,
Tham, El L
,
Sugden, Peter H
,
Clerk, Angela
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes
Author(s) :
Cullingford, Timothy E.
,
Markou, T.
,
Fuller, Stephen John
,
Giraldo Ramirez, Alejandro
,
Pikkarainern, Sampsa
,
Zoumpoulidou, Georgia
Description :
Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividing cells or hypertrophy in terminally differentiated cardiomyocytes. In cardiomyocytes, endothelin-1 rapidly (within minutes) stimulates protein kinase signaling, including extracellular-signal regulat...
Repository :
CentAUR
Language(s) :
Undetermined
Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes
Author(s) :
Cullingford, Timothy E
,
Markou, Thomais
,
Fuller, Stephen J
,
Giraldo, Alejandro
,
Pikkarainen, Sampsa
,
Zoumpoulidou, Georgia
Description :
A microarray profiling study of rat cardiomyocytes provides insights into early and second phase transcriptional responses induced by endothelin-1 and shows the importance of ERK1/2 signaling.
Repository :
Europe PubMed Central
Language(s) :
English
1
Found 10 documents, displaying page 1 of 1