Results
author = "Cooke, Marcus S."
Harmonising measurements of 8-oxo-7,8-dihydro-2'-deoxyguanosine in cellular DNA and urine.
Author(s) :
Moller, Peter
,
Cooke, Marcus S.
,
Collins, Andrew
,
Olinski, Ryszard
,
Rozalski, Rafal
,
Loft, Steffen
Description :
Levels of oxidatively damaged cellular DNA and urinary excretion of damaged 2'-deoxyribonuclosides are widely measured in biomonitoring studies examining the role of oxidative stress induced by environmental exposures, lifestyle factors and development of disease. This has promoted efforts to harmon...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Urinary measurement of 8-OxodG, 8-OxoGua, and 5HMUra: a noninvasive assessment of oxidative damage to DNA.
Author(s) :
Olinski, Ryszard
,
Rozalski, Rafal
,
Gackowski, Daniel
,
Foksinski, Marek
,
Siomek, Agnieszka
,
Cooke, Marcus S.
Description :
Numerous DNA repair pathways exist to prevent the persistence of damage, and are integral to the maintenance of genome stability, and hence prevention of disease. Excised lesions arising from repair may ultimately appear in the urine where their measurement has been acknowledged to be reflective of ...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
Description :
Oxidative damage to DNA is regarded as an important step in carcinogenesis. These lesions may arise as a consequence of exposure to xenobiotics, but are also generated as a consequence of endogenous generation of oxidizing compounds. Measurements of oxidative damage to guanines, such as 8-oxo-7, 8-d...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Evidence for attenuated cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine removal in cancer patients.
Author(s) :
Cooke, Marcus S.
,
Rozalski, Rafal
,
Dove, Rosamund
,
Gackowski, Daniel
,
Siomek, Agnieszka
,
Evans, Mark D.
,
Olinski, Ryszard
Description :
Measurement of the products of oxidatively damaged DNA in urine is a frequently used means by which oxidative stress may be assessed non-invasively. We believe that urinary DNA lesions, in addition to being biomarkers of oxidative stress, can potentially provide more specific information, for exampl...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Combination of azathioprine and UVA irradiation is a major source of cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine.
Author(s) :
Cooke, Marcus S.
,
Duarte, Tiago L.
,
Cooper, Deborah
,
Chen, Jie
,
Nandagopal, Sridevi
,
Evans, Mark D.
Description :
Thiopurine antimetabolites, such as azathioprine (Aza) and 6-thioguanine (6-TG), are widely used in the treatment of cancer, inflammatory conditions and organ transplantation patients. Recent work has shown that cells treated with 6-TG and UVA generate ROS, with implied oxidatively generated modific...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Recommendations for standardized description of and nomenclature concerning oxidatively damaged nucleobases in DNA.
Author(s) :
Cooke, Marcus S.
,
Loft, Steffen
,
Olinski, Ryszard
,
Evans, Mark D.
,
Bialkowski, Karol
,
Wagner, J. Richard
,
Dedon, Peter C.
Description :
We are very grateful to Dr. Gerry Moss,
President, IUPAC Division VIII, for his useful comments in
the drafting of this document. M.S.C., S.L., P.M., R.O., K.B.,
and M.D.E. are partners of ECNIS (Environmental Cancer Risk,
Nutrition and Individual Susceptibility), a network of excellence
operating w...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids.
Author(s) :
Cadet, Jean
,
Loft, Steffen
,
Olinski, Ryszard
,
Evans, Mark D.
,
Bialkowski, Karol
,
Richard Wagner, J.
,
Dedon, Peter C.
Description :
A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxi...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine in saliva and urine.
Author(s) :
Cooke, Marcus S.
,
Singh, Rajinder
,
Hall, Georgina K.
,
Mistry, Vilas
,
Duarte, Tiago L.
,
Farmer, Peter B.
,
Evans, Mark D.
Description :
While ELISA is a frequently used means of assessing 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) in biological fluids, differences in baseline urinary 8-oxodG levels, compared to chromatographic techniques, have raised questions regarding the specificity of immunoassays. Recently, ELISA of salivary ...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients.
Author(s) :
Cooke, Marcus S.
,
Osborne, Joy E.
,
Singh, Rajinder
,
Mistry, Vilas
,
Farmer, Peter B.
,
Evans, Mark D.
,
Hutchinson, Peter E.
Description :
Renal transplant patients are at a greatly increased risk of skin malignancy, particularly squamous cell carcinoma (SCC), a tumor closely associated with UV exposure. There is also significant interindividual skin cancer risk among transplant patients, with evidence suggesting that this derives from...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells.
Author(s) :
Song, Renfang
,
Duarte, Tiago L.
,
Almeida, Gabriela M.
,
Farmer, Peter B.
,
Cooke, Marcus S.
,
Zhang, Wenbing
,
Sheng, Guoying
Description :
Polybrominated diphenyl ethers (PBDEs) are commonly used as flame retardants in a variety of commercial and household products. They have been detected in the environment and accumulate in mammalian tissues and fluids. PBDE toxicity is thought to be associated with endocrine disruption, developmenta...
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English