Results
author = "Chiap, P."
Validation of an automated method for the liquid chromatographic determination of atenolol in plasma: application of a new validation protocol
Description :
In order to test the applicability of a new strategy by a Commission of the Societe Francaise des Sciences et Techniques Pharmaceutiques (SFSTP) for the validation of bioanalytical methods, an automated method was developed for the determination of atenolol in human plasma. This method was based on ...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Liquid chromatographic analysis of local anesthetics in human plasma after sample preparation by on-line dialysis. Optimization by use of experimental design
Description :
A fully automated method involving dialysis, clean-up and enrichment of the dialysate on a pre-column packed with a strong cation-exchange phase, and subsequent liquid chromatographic (LC) analysis with UV detection at 220 nm has been developed for the determination of local anesthetics (prilocaine,...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Using total error as decision criterion in analytical method transfer
Author(s) :
Dewe, W.
,
Govaerts, Bernadette
,
Boulanger, Bruno
,
Rozet, E.
,
Chiap, P.
,
Hubert, Ph.
Description :
An analytical transfer is a complete process that consists in transferring a validated analytical method from a sending laboratory (called sender) to a receiving laboratory (called receiver) after having experimentally demonstrated that it also masters the method. The decision to transfer an analyti...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
LC method for the determination of R-timolol in S-timolol maleate: Validation of its ability to quantify and uncertainty assessment
Author(s) :
Marini, RD
,
Chiap, P.
,
Boulanger, Bruno
,
Rudaz, S
,
Rozet, E.
,
Crommen, J.
,
Hubert, P.
Description :
This article presents the validation results of a chiral liquid chromatographic (LC method previously developed for the quantitative determination of R-timolol in S-timoloi maleate samples. A novel validation strategy based on the accuracy profiles was used to select the most appropriate regression ...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Influence of the nature of the electrolyte on the chiral separation of basic compounds in nonaqueous capillary electrophoresis using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin
Description :
The influence on the enantiomeric resolution of the nature of the cationic BGE component (sodium, ammonium or potassium) and that of the anionic component (chloride, formate, methanesulfonate or camphorsulfonate) as well as the concentration of heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin (...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Uncertainty assessment from robustness testing applied on an LC assay for R-timolol and other related substances in S-timolol maleate
Description :
The robustness testing of a normal-phase liquid chromatographic (LC) method for the determination of R-timolol and other related substances in S-timolol maleate was performed applying a two-level Plackett-Burman design. Two qualitative and five quantitative factors were examined. Two types of respon...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Development of response models for optimising HPLC methods
Author(s) :
Dewe, W.
,
Marini, RD
,
Chiap, P.
,
Hubert, P.
,
Crommen, J.
,
Boulanger, Bruno
,
6th Annual Congress of Chemometrics
Description :
For optimizing a liquid chromatographic method, direct modeling some responses like minimum resolution is sometimes difficult to perform. By modeling the retention time at apex and the times associated to 13.4% of the peak height, it is possible to obtain estimations of these responses using an adeq...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
An analysis of the SFSTP guide on validation of chromatographic bioanalytical methods: progresses and limitations
Author(s) :
Boulanger, Bruno
,
Chiap, P.
,
Dewe, W.
,
Crommen, J.
,
Hubert, P.
,
Joint Meeting of the 7th International Symposium on Drug Analysis/13th International Symposium on Pharmaceutical and Biomedial Analysis
Description :
The Societe Francaise des Sciences et Techniques Pharmaceutiques (SFSTP) published in 1997 a guide on the validation of chromatographic bio-analytical methods, which introduces new concepts in three different areas: stages of the validation, test of acceptability of a method and design of experiment...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Development and validation of an automated method for the liquid chromatographic determination of sotalol in plasma using dialysis and trace enrichment on a cation-exchange pre-column as on-line sample preparation
Author(s) :
Chiap, P.
,
Ceccato, A.
,
Buraglia, BM
,
Boulanger, Bruno
,
Hubert, P.
,
Crommen, J.
,
11th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2000)
Description :
A fully automated method for the determination of sotalol in human plasma was developed. involving dialysis through a cellulose acetate membrane, clean-up and enrichment of the dialysate on a strong cation-exchange pre-column and subsequent liquid chromatographic (LC) analysis with UV detection. All...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
Simultaneous determination of methylphenobarbital enantiomers and phenobarbital in human plasma by on-line coupling of an achiral precolumn to a chiral liquid chromatographic column
Author(s) :
Ceccato, A.
,
Boulanger, Bruno
,
Chiap, P.
,
Hubert, P.
,
Crommen, J.
,
5th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers
Description :
A fully automated liquid chromatographic (LC) method for the simultaneous determination of methylphenobarbital enantiomers and phenobarbital in human plasma has been developed. The method is based on the use of a precolumn packed with an internal-surface reversed-phase packing material (LiChrospher ...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English