Results
author = "Castronovo, Vincenzo"
La protéine P53, protectrice de l'intégrité du génome: rôle dans la genèse des cancers Protein P53, Protector of Genome Integrity: Its Role in Carcinogenesis
Author(s) :
Bellahcene, Akeila
,
Merville, Marie-Paule
,
Gielen Jacques
,
Lambotte, René
,
Simar, Léon
,
Castronovo, Vincenzo
Description :
L'homéostasie des tissus de l'organisme est le résultat d'un équilibre dynamique stable entre des facteurs de régulation positifs et négatifs. Ceux-ci contrôlent la prolifération des cellules et déterminent leur appartenance tissulaire. Des données récentes indiquent que l'apparition des cancers ré...
Repository :
ORBi (University of Liège)
Language(s) :
French
Identification of stromal proteins overexpressed in nodular sclerosis Hodgkin lymphoma.
Author(s) :
Kischel, Philippe
,
Waltregny, David
,
Greffe, Yannick
,
Mazzucchelli, Gabriel
,
De Pauw, Edwin
,
de Leval, Laurence
Description :
ABSTRACT: Hodgkin lymphoma (HL) represents a category of lymphoid neoplasms with unique features, notably the usual scarcity of tumour cells in involved tissues. The most common subtype of classical HL, nodular sclerosis HL, characteristically comprises abundant fibrous tissue stroma. Little informa...
Repository :
ORBi (University of Liège)
Language(s) :
English
Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis
Author(s) :
Dumont, Bruno
,
Castronovo, Vincenzo
,
Peulen, Olivier
,
BLETARD, Noëlla
,
Clézardin, Philippe
,
Delvenne, Philippe
Description :
The classical fate of metastasizing breast cancer cells is to seed and form secondary colonies in bones. The molecules closely associated with these processes are predominantly present at the cell surface and in the extracellular space, establishing the first contacts with the target tissue. In this...
Repository :
ORBi (University of Liège)
Language(s) :
English
Cloning and expression of a new HOXC6 transcript encoding a repressing protein
Author(s) :
Chariot, Alain
,
Castronovo, Vincenzo
,
Le, P.
,
Gillet, C.
,
Sobel, Mark E
,
Gielen, Jacques
Description :
Homeodomain-containing proteins are transcription factors that regulate the co-ordinated expression of multiple genes involved in development, differentiation and malignant transformation. In an attempt to characterize expressed homeobox (HOX) genes in breast cancer cells, we cloned two distinct HOX...
Repository :
ORBi (University of Liège)
Language(s) :
English
Enhancement of Tamoxifen-Induced E-Cadherin Function by Ca2+ Channel Antagonists in Human Breast Cancer Mcf7/6 Cells
Author(s) :
Charlier, Corinne
,
Bruyneel, E.
,
Lechanteur, Chantal
,
Bracke, M.
,
Mareel, M.
,
Castronovo, Vincenzo
Description :
Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized. Tamoxifen was recently shown to restore the E-cadherin function of human breast cancer MCF7/6 cells and to suppress their invasive ph...
Repository :
ORBi (University of Liège)
Language(s) :
English
INTRA-TUMORAL HETEROGENEITY AND RATIONAL SELECTION OF ANTIGENS FOR TARGETED THERAPY OF LIVER METASTASES
Author(s) :
Turtoi, Andrei
,
Blomme, Arnaud
,
Delvaux, David
,
Dumont, Bruno
,
SOMJA, Joan
,
Debois, Delphine
,
DELVENNE, Philippe
Description :
Objectives: Targeted therapies of liver metastases are gaining a major stake in current and future treatment options. However, the malignant lesions are heterogeneous in nature offering niches for cancer cells causing treatment resistance and relapse. Therefore, a rational strategy is needed to sele...
Repository :
ORBi (University of Liège)
Language(s) :
English
Dual function of ERRalpha in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin.
Author(s) :
Fradet, Anais
,
Sorel, Helene
,
Bouazza, Lamia
,
Goehrig, Delphine
,
Depalle, Baptiste
,
Bellahcene, Akeila
,
Castronovo, Vincenzo
Description :
Bone metastasis is a complication occurring in up to 70% of advanced breast cancer patients. The estrogen receptor-related receptor alpha (ERRalpha) has been implicated in breast cancer and bone development, prompting us to examine whether ERRalpha may function in promoting the osteolytic growth of ...
Repository :
ORBi (University of Liège)
Language(s) :
English
EANM 2012: In Ovo PET Imaging Of A Human Colorectal Carcinoma Model In Chicken Chorioallantoic Membrane
Author(s) :
Warnock, Geoffrey
,
Turtoi, Andrei
,
Blomme, Arnaud
,
Gonzalez, Arnaud
,
Bretin, Florian
,
Bahri, Mohamed Ali
,
Lemaire, Christian
Description :
Aim. The objective of this study was to use in vivo PET/CT imaging as a validation tool for a novel human colorectal carcinoma model being developed in chicken chorioallantoic membrane (CAM). For this initial pilot study a cell line modeling colon cancer was selected and imaged using [18F]fluorodeox...
Repository :
ORBi (University of Liège)
Language(s) :
English
The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells.
Author(s) :
Turtoi, Andrei
,
Mottet, Denis
,
Matheus, Nicolas
,
Dumont, Bruno
,
Peixoto, Paul
,
Hennequière, Vincent
,
Deroanne, Christophe
Description :
Histone deacetylases (HDACs) are a family of 18 enzymes that deacetylate lysine residues of both histone and nonhistone proteins and to a large extent govern the process of angiogenesis. Previous studies have shown that specific inhibition of HDAC7 blocks angiogenesis both in vitro and in vivo. Howe...
Repository :
ORBi (University of Liège)
Language(s) :
English
Sparc-like protein 1 is a new marker of human glioma progression.
Author(s) :
Turtoi, Andrei
,
Musmeci, Davide
,
Naccarato, Antonio Giuseppe
,
Scatena, Cristian
,
Ortenzi, Valerio
,
Kiss, Robert
Description :
High-grade gliomas (glioblastomas) are the most common and deadly brain tumors in adults, currently with no satisfactory treatment available. Apart from de novo glioblastoma, it is currently accepted that these malignancies mainly progress from lower grade glial tumors. However, the molecular entiti...
Repository :
ORBi (University of Liège)
Language(s) :
English