Results
author = "Bruzzone, Santina"
Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors
Author(s) :
Bruzzone, Santina
,
Kunerth, Svenja
,
Zocchi, Elena
,
De Flora, Antonio
,
Guse, Andreas H.
Description :
The role of cyclic ADP-ribose in the amplification of subcellular and global Ca2+ signaling upon stimulation of P2Y purinergic receptors was studied in 3T3 fibroblasts. Either (1) 3T3 fibroblasts (CD38− cells), (2) 3T3 fibroblasts preloaded by incubation with extracellular cyclic ADP-ribose (cADPR),...
Repository :
Europe PubMed Central
Language(s) :
English
Emerging Functions of Extracellular Pyridine Nucleotides
Author(s) :
Billington, Richard A
,
Bruzzone, Santina
,
De Flora, Antonio
,
Genazzani, Armando A
,
Koch-Nolte, Friedrich
,
Ziegler, Mathias
Description :
In addition to the well-known metabolic functions of NAD and NADP, it is rapidly emerging that these 2 pyridine nucleotides and their derivatives also play important roles in cell signaling. Surprisingly, a number of NAD(P) metabolizing enzymes and NAD(P) targets have been found on the outer surface...
Repository :
Europe PubMed Central
Language(s) :
English
The temperature-signaling cascade in sponges involves a heat-gated cation channel, abscisic acid, and cyclic ADP-ribose
Author(s) :
Zocchi, Elena
,
Carpaneto, Armando
,
Cerrano, Carlo
,
Bavestrello, Giorgio
,
Giovine, Marco
,
Bruzzone, Santina
,
Guida, Lucrezia
Description :
Sponges (phylum Porifera) are the phylogenetically oldest
metazoan animals, their evolution dating back to 600 million years ago.
Here we demonstrate that sponges express ADP-ribosyl cyclase activity,
which converts NAD+ into cyclic ADP-ribose, a potent and
universal intracellular Ca2+ mobilizer...
Repository :
Europe PubMed Central
Language(s) :
English
Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets
Author(s) :
Bruzzone, Santina
,
Parenti, Marco Daniele
,
Grozio, Alessia
,
Ballestrero, Alberto
,
Bauer, Inga
,
Rio, Alberto Del
Description :
Sirtuins are a family of NAD+-dependent enzymes that was proposed to control organismal life span about a decade ago. While such role of sirtuins is now debated, mounting evidence involves these enzymes in numerous physiological processes and disease conditions, including metabolism, nutritional beh...
Repository :
Europe PubMed Central
Language(s) :
English
Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger
Author(s) :
Bruzzone, Santina
,
Moreschi, Iliana
,
Usai, Cesare
,
Guida, Lucrezia
,
Damonte, Gianluca
,
Salis, Annalisa
,
Scarfì, Sonia
Description :
Abscisic acid (ABA) is a phytohormone involved in fundamental physiological processes of higher plants, such as response to abiotic stress (temperature, light, drought), regulation of seed dormancy and germination, and control of stomatal closure. Here, we provide evidence that ABA stimulates severa...
Repository :
Europe PubMed Central
Language(s) :
English
ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells
Author(s) :
Basile, Giovanna
,
Taglialatela-Scafati, Orazio
,
Damonte, Gianluca
,
Armirotti, Andrea
,
Bruzzone, Santina
,
Guida, Lucrezia
Description :
ADP-ribosyl cyclases are ubiquitous enzymes responsible for synthesis from NAD+ of the intracellular calcium-releasing signal molecules cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP+). Here, we show that cyclases from lower and higher Metazoa also synthesize thre...
Repository :
Europe PubMed Central
Language(s) :
English
Abscisic Acid Released by Human Monocytes Activates Monocytes and Vascular Smooth Muscle Cell Responses Involved in Atherogenesis*
Author(s) :
Magnone, Mirko
,
Bruzzone, Santina
,
Guida, Lucrezia
,
Damonte, Gianluca
,
Millo, Enrico
,
Scarfì, Sonia
,
Usai, Cesare
Description :
Abscisic acid (ABA) is a phytohormone recently identified as a new endogenous pro-inflammatory hormone in human granulocytes. Here we report the functional activation of human monocytes and vascular smooth muscle cells by ABA. Incubation of monocytes with ABA evokes an intracellular Ca2+ rise throug...
Repository :
Europe PubMed Central
Language(s) :
English
P2X7-mediated Increased Intracellular Calcium Causes Functional Derangement in Schwann Cells from Rats with CMT1A Neuropathy*
Author(s) :
Nobbio, Lucilla
,
Sturla, Laura
,
Fiorese, Fulvia
,
Usai, Cesare
,
Basile, Giovanna
,
Moreschi, Iliana
,
Benvenuto, Federica
Description :
Charcot-Marie-Tooth (CMT) is the most frequent inherited neuromuscular disorder, affecting 1 person in 2500. CMT1A, the most common form of CMT, is usually caused by a duplication of chromosome 17p11.2, containing the PMP22 (peripheral myelin protein-22) gene; overexpression of PMP22 in Schwann cell...
Repository :
Europe PubMed Central
Language(s) :
English
Diadenosine Homodinucleotide Products of ADP-ribosyl Cyclases Behave as Modulators of the Purinergic Receptor P2X7*
Author(s) :
Bruzzone, Santina
,
Basile, Giovanna
,
Chothi, Madhu Parakkottil
,
Nobbio, Lucilla
,
Usai, Cesare
,
Jacchetti, Emanuela
Description :
ADP-ribosyl cyclases from both vertebrates and invertebrates were previously shown to produce two isomers of P1,P2 diadenosine 5′,5′"-P1, P2-diphosphate, P18 and P24, from cyclic ADP-ribose (cADPR) and adenine. P18 and P24 are characterized by an unusual N-glycosidic linkage in one of the adenylic m...
Repository :
Europe PubMed Central
Language(s) :
English
Catastrophic NAD+ Depletion in Activated T Lymphocytes Through Nampt Inhibition Reduces Demyelination and Disability in EAE
Author(s) :
Bruzzone, Santina
,
Fruscione, Floriana
,
Morando, Sara
,
Ferrando, Tiziana
,
Poggi, Alessandro
,
Garuti, Anna
,
D'Urso, Agustina
Description :
Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD+ synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T lymphocytes and on preliminary reports of lymphopenia in FK866 treated patients...
Repository :
Digital Access to Scholarship at Harvard
Language(s) :
English