Results
author = "Brown, Wendy C."
Conservation of Babesia bovis Small Heat Shock Protein (Hsp20) among Strains and Definition of T Helper Cell Epitopes Recognized by Cattle with Diverse Major Histocompatibility Complex Class II Haplotypes
Description :
Babesia bovis small heat shock protein (Hsp20) is recognized by CD4+ T lymphocytes from cattle that have recovered from infection and are immune to challenge. This candidate vaccine antigen is related to a protective antigen of Toxoplasma gondii, Hsp30/bag1, and both are members of the α-crystallin ...
Repository :
Europe PubMed Central
Language(s) :
English
Maintenance of Antibody to Pathogen Epitopes Generated by Segmental Gene Conversion Is Highly Dynamic during Long-Term Persistent Infection▿ †
Description :
Multiple bacterial and protozoal pathogens utilize gene conversion to generate rapid intrahost antigenic variation. Both large- and small-genome pathogens expand the size of the variant pool via a combinatorial process in which oligonucleotide segments from distinct donor loci are recombined in vari...
Repository :
Europe PubMed Central
Language(s) :
English
Physical Linkage of Naturally Complexed Bacterial Outer Membrane Proteins Enhances Immunogenicity▿
Author(s) :
Macmillan, Henriette
,
Norimine, Junzo
,
Brayton, Kelly A.
,
Palmer, Guy H.
,
Brown, Wendy C.
Description :
The outer membrane proteins (OMPs) of bacterial pathogens are essential for their growth and survival and especially for attachment and invasion of host cells. Since the outer membrane is the interface between the bacterium and the host cell, outer membranes and individual OMPs are targeted for deve...
Repository :
Europe PubMed Central
Language(s) :
English
Characterization of a Phenotypically Unique Population of CD13+ Dendritic Cells Resident in the Spleen
Author(s) :
Zhuang, Yan
,
Mwangi, Waithaka
,
Brown, Wendy C.
,
Davis, William C.
,
Hope, Jayne C.
,
Palmer, Guy H.
Description :
Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a+ CD11c+ CD13+ CD172+ CD205+ population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimu...
Repository :
Europe PubMed Central
Language(s) :
English
Bovine CD4+ T-Lymphocyte Clones Specific for Rhoptry-Associated Protein 1 of Babesia bigemina Stimulate Enhanced Immunoglobulin G1 (IgG1) and IgG2 Synthesis
Author(s) :
Brown, Wendy C.
,
McElwain, Terry F.
,
Palmer, Guy H.
,
Chantler, Sue Ellen
,
Estes, D. Mark
Description :
Optimal protective immunity against babesial infection is postulated to require both complement-fixing and opsonizing antibodies in addition to gamma interferon (IFN-γ)-mediated macrophage activation. The rhoptry-associated protein 1 (RAP-1) of Babesia bigemina induces partial protective immunity an...
Repository :
Europe PubMed Central
Language(s) :
English
The immunization-induced antibody response to the Anaplasma marginale major surface protein 2 and its association with protective immunity
Author(s) :
Noh, Susan M.
,
Zhuang, Yan
,
Futse, James E.
,
Brown, Wendy C.
,
Brayton, Kelly A.
,
Palmer, Guy H.
Description :
Many vector-borne pathogens evade clearance via rapid variation in their immunogenic surface expressed proteins. This is exemplified by Anaplasma marginale, a tick-borne bacterial pathogen that generates major surface protein 2 (Msp2) variants to provide for immune escape and allow long-term pathoge...
Repository :
Europe PubMed Central
Language(s) :
English
Anaplasma marginale Major Surface Protein 2 CD4+-T-Cell Epitopes Are Evenly Distributed in Conserved and Hypervariable Regions (HVR), Whereas Linear B-Cell Epitopes Are Predominantly Located in the HVR
Author(s) :
Abbott, Jeffrey R.
,
Palmer, Guy H.
,
Howard, Chris J.
,
Hope, Jayne C.
,
Brown, Wendy C.
Description :
Organisms in the genus Anaplasma express an immunodominant major surface protein 2 (MSP2), composed of a central hypervariable region (HVR) flanked by highly conserved regions. Throughout Anaplasma marginale infection, recombination results in the sequential appearance of novel MSP2 variants and sub...
Repository :
Europe PubMed Central
Language(s) :
English
Anaplasma marginale Infection with Persistent High-Load Bacteremia Induces a Dysfunctional Memory CD4+ T Lymphocyte Response but Sustained High IgG Titers▿
Author(s) :
Han, Sushan
,
Norimine, Junzo
,
Brayton, Kelly A.
,
Palmer, Guy H.
,
Scoles, Glen A.
,
Brown, Wendy C.
Description :
Control of blood-borne infections is dependent on antigen-specific effector and memory T cells and high-affinity IgG responses. In chronic infections characterized by a high antigen load, it has been shown that antigen-specific T and B cells are vulnerable to downregulation and apoptosis. Anaplasma ...
Repository :
Europe PubMed Central
Language(s) :
English
Identification of Anaplasma marginale Outer Membrane Protein Antigens Conserved between A. marginale Sensu Stricto Strains and the Live A. marginale subsp. centrale Vaccine ▿
Author(s) :
Agnes, Joseph T.
,
Brayton, Kelly A.
,
LaFollett, Megan
,
Norimine, Junzo
,
Brown, Wendy C.
,
Palmer, Guy H.
Description :
Live vaccination with Anaplasma marginale subsp. centrale (synonym for Anaplasma centrale) induces protection against severe disease upon challenge with A. marginale sensu stricto strains. Despite over a century of field use, the targets of protective immunity remained unknown. Using a broad proteom...
Repository :
Europe PubMed Central
Language(s) :
English
Association and Evidence for Linked Recognition of Type IV Secretion System Proteins VirB9-1, VirB9-2, and VirB10 in Anaplasma marginale
Author(s) :
Morse, Kaitlyn
,
Norimine, Junzo
,
Palmer, Guy H.
,
Sutten, Eric L.
,
Baszler, Timothy V.
,
Brown, Wendy C.
Description :
Like several other bacterial pathogens, Anaplasma marginale has an outer membrane that induces complete protection from infection and disease. However, the proteins that confer protective immunity and whether protection requires interacting proteins and/or linked T-cell and immunoglobulin G epitopes...
Repository :
Europe PubMed Central
Language(s) :
English