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author = "Brown, Nicholas R."
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Found 4 documents, displaying page 1 of 1

A new crystal form of Lys48-linked diubiquitin

Author(s) : Trempe, Jean-François , Brown, Nicholas R. , Noble, Martin E. M. , Endicott, Jane A.
Description : A new crystal form of Lys48-linked diubiquitin was obtained and its structure was determined by X-ray crystallography to 1.6 Å resolution.
Repository : Europe PubMed Central
Language(s) : English

Conservation of Heterochromatin Protein 1 Function

Author(s) : Wang, Guozheng , Ma, Alicia , Chow, Cheok-man , Horsley, David , Brown, Nicholas R. , Cowell, Ian G. , Singh, Prim B.
Description : Heterochromatin represents a cytologically visible state of heritable gene repression. In the yeast, Schizosaccharomyces pombe, the swi6 gene encodes a heterochromatin protein 1 (HP1)-like chromodomain protein that localizes to heterochromatin domains, including the centromeres, telomeres, and the d...
Repository : Europe PubMed Central
Language(s) : English

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12*

Author(s) : Riedinger, Christiane , Boehringer, Jonas , Trempe, Jean-Francois , Lowe, Edward D. , Brown, Nicholas R. , Gehring, Kalle
Description : Schizosaccharomyces pombe Rpn10 (SpRpn10) is a proteasomal ubiquitin (Ub) receptor located within the 19 S regulatory particle where it binds to subunits of both the base and lid subparticles. We have solved the structure of full-length SpRpn10 by determining the crystal structure of the von Willebr...
Repository : Europe PubMed Central
Language(s) : English

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

Author(s) : Trempe, Jean-François , Brown, Nicholas R , Lowe, Edward D , Gordon, Colin , Campbell, Iain D , Noble, Martin E M , Endicott, Jane A
Description : The ubiquitin-pathway associated (UBA) domain is a 40-residue polyubiquitin-binding motif. The Schizosaccharomyces pombe protein Mud1 is an ortholog of the Saccharomyces cerevisiae DNA-damage response protein Ddi1 and binds to K48-linked polyubiquitin through its UBA domain. We have solved the cryst...
Repository : Europe PubMed Central
Language(s) : English
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Found 4 documents, displaying page 1 of 1