Results
author = "Brisken, Cathrin"
ER and PR signaling nodes during mammary gland development
Description :
The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (ER) and progesterone receptor (PR) signaling stems from in vitro studies with hormone recept...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium
Description :
The cytokine hormones prolactin and erythropoietin mediate tissue-specific developmental outcomes by activating their cognate receptors, prolactin receptor (PrlR) and erythropoietin receptor (EpoR), respectively. The EpoR is essential for red blood cell formation, whereas a principal function of Prl...
Repository :
Europe PubMed Central
Language(s) :
English
Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland
Description :
Estradiol is a major regulator of postnatal mammary gland development and thought to exert its effects through estrogen receptor α (ERα) expressed in the mammary gland stroma and epithelium. Previous studies, however, were confounded by the use of an ERα mutant strain that retains some of the protei...
Repository :
Europe PubMed Central
Language(s) :
English
ER and PR signaling nodes during mammary gland development
Description :
The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (ER) and progesterone receptor (PR) signaling stems from in vitro studies with hormone recept...
Repository :
Infoscience
Language(s) :
English
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
Author(s) :
Devgan, Vikram
,
Mammucari, Cristina
,
Millar, Sarah E.
,
Brisken, Cathrin
,
Dotto, G. Paolo
Description :
In keratinocytes, the cyclin/CDK inhibitor p21WAF1/Cip1 is a direct transcriptional target of Notch1 activation; loss of either the p21 or Notch1 genes expands stem cell populations and facilitates tumor development. The Notch1 tumor-suppressor function was associated with down-regulation of Wnt sig...
Repository :
Europe PubMed Central
Language(s) :
English
Stem cells in chemical carcinogenesis.
Author(s) :
Dietrich, Cornelia
,
Weiss, Carsten
,
Bockamp, Ernesto
,
Brisken, Cathrin
,
Roskams, Tania
,
Morris, Rebecca
,
Oesch-Bartlomowicz, Barbara
Description :
Repository :
ECNIS Repository (Environmental Cancer Risk, Nutrition and Individual Susceptibility Repository)
Language(s) :
English
A paracrine role for the epithelial progesterone receptor in mammary gland development
Author(s) :
Brisken, Cathrin
,
Park, Sissela
,
Vass, Tibor
,
Lydon, John P.
,
O’Malley, Bert W.
,
Weinberg, Robert A.
Description :
Recently generated progesterone receptor (PR)-negative (PR−/−) mice provide an excellent model for dissecting the role of progesterone in the development of the mammary gland during puberty and pregnancy. However, the full extent of the mammary gland defect in these mice caused by the absence of the...
Repository :
Europe PubMed Central
Language(s) :
English
Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
Author(s) :
Beleut, Manfred
,
Rajaram, Renuga Devi
,
Caikovski, Marian
,
Ayyanan, Ayyakkannu
,
Germano, Davide
,
Choi, Yongwon
,
Schneider, Pascal
Description :
The mouse mammary gland develops postnatally under the control of female reproductive hormones. Estrogens and progesterone trigger morphogenesis by poorly understood mechanisms acting on a subset of mammary epithelial cells (MECs) that express their cognate receptors, estrogen receptor α (ERα) and p...
Repository :
Europe PubMed Central
Language(s) :
English
Cyclin D1 Enhances the Response to Estrogen and Progesterone by Regulating Progesterone Receptor Expression ▿
Author(s) :
Yang, Chuanwei
,
Chen, Li
,
Li, Cuiqi
,
Lynch, Mary C.
,
Brisken, Cathrin
,
Schmidt, Emmett V.
Description :
Estrogen and progesterone are the defining hormones of normal female development, and both play critical roles in breast carcinogenesis. Cyclin D1 is a breast cancer oncogene whose amplification is linked to poor prognosis in estrogen and progesterone receptor-positive breast cancers. Here we report...
Repository :
Europe PubMed Central
Language(s) :
English
An oestrogen-dependent model of breast cancer created by transformation of normal human mammary epithelial cells
Author(s) :
Duss, Stephan
,
André, Sylvie
,
Nicoulaz, Anne-Laure
,
Fiche, Maryse
,
Bonnefoi, Hervé
,
Brisken, Cathrin
,
Iggo, Richard D
Description :
Repository :
Europe PubMed Central
Language(s) :
English