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author = "Bhandari, Janhavi"
1

Found 6 documents, displaying page 1 of 1

Structure of fructose bisphosphate aldolase from Bartonella henselae bound to fructose 1,6-bisphosphate

Author(s) : Gardberg, Anna , Abendroth, Jan , Bhandari, Janhavi , Sankaran, Banumathi , Staker, Bart
Description : While other aldolases crystallize readily in the apo form, diffraction-quality crystals of B. henselae aldolase could only be obtained in the presence of the native substrate. The quaternary structure is tetrameric, as is typical of aldolases.
Repository : Europe PubMed Central
Language(s) : English

Structure of fructose bisphosphate aldolase from Encephalitozoon cuniculi

Author(s) : Gardberg, Anna , Sankaran, Banumathi , Davies, Doug , Bhandari, Janhavi , Staker, Bart , Stewart, Lance
Description : The eukaryotic parasite E. cuniculi expresses a fructose bisphosphate aldolase that crystallizes readily in the presence of the partial substrate analog phosphate. This aldolase–phosphate structure and that of the sugar-bound Schiff base are reported. E. cuniculi aldolase displays a dimeric structur...
Repository : Europe PubMed Central
Language(s) : English

High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease

Author(s) : Bryan, Cassie M. , Bhandari, Janhavi , Napuli, Alberto J. , Leibly, David J. , Choi, Ryan , Kelley, Angela , Van Voorhis, Wesley C.
Description : An overview of the standard SSGCID protein-purification protocol is given and success rates and cleavage alternatives are discussed.
Repository : Europe PubMed Central
Language(s) : English

Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei

Author(s) : Begley, Darren W. , Hartley, Robert C. , Davies, Douglas R. , Edwards, Thomas E. , Leonard, Jess T. , Abendroth, Jan
Description : As part of the Seattle Structural Genomics Center for Infectious Disease, we seek to enhance structural genomics with ligand-bound structure data which can serve as a blueprint for structure-based drug design. We have adapted fragment-based screening methods to our structural genomics pipeline to ge...
Repository : Europe PubMed Central
Language(s) : English

Structures of phosphopantetheine adenylyltransferase from Burkholderia pseudomallei

Author(s) : Edwards, Thomas E. , Leibly, David J. , Bhandari, Janhavi , Statnekov, Jacob B. , Phan, Isabelle , Dieterich, Shellie H.
Description : Phosphopantetheine adenylyltransferase (PPAT) reversibly converts ATP and 4′-phosphopantetheine into dephospho-coenzyme A and pyrophosphate. Crystal structures are presented of PPAT from B. pseudomallei, the pathogenic bacterium that causes melioidosis.
Repository : Europe PubMed Central
Language(s) : English

BrabA.11339.a: anomalous diffraction and ligand binding guide towards the elucidation of the function of a ‘putative β-lactamase-like protein’ from Brucella melitensis

Author(s) : Abendroth, Jan , Sankaran, Banumathi , Edwards, Thomas E. , Gardberg, Anna S. , Dieterich, Shellie , Bhandari, Janhavi
Description : The structure of a β-lactamase-like protein from B. melitensis was solved independently using two data sets with anomalous signal. Anomalous Fourier maps could confirm the identity of two metal ions in the active site. AMP-bound and GMP-bound structures provide hints to the possible function of the ...
Repository : Europe PubMed Central
Language(s) : English
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Found 6 documents, displaying page 1 of 1