Results
author = "Basler, K"
Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic.
Description :
Members of the TGF beta superfamily of secreted signaling molecules regulate growth and cellular patterning during development and interact with specific type I and type II membrane receptors possessing a cytoplasmic serine/threonine kinase domain. We describe two members of the type I receptor fami...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member.
Description :
Distinct cell types differentiate along the dorsoventral axis of the neural tube. We have cloned and characterized a novel member of the TGF beta gene family, dorsalin-1 (dsl-1), that appears to regulate cell differentiation within the neural tube. dsl-1 is expressed selectively in the dorsal neural...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye.
Description :
Cell fate in the developing eye is determined by a cascade of inductive interactions. In this process, the sevenless protein--a receptor tyrosine kinase--is required for the specification of the R7 photoreceptor cell fate. We have constructed a gain-of-function sevenless mutation (SevS11) by overexp...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
Direct and long-range action of a wingless morphogen gradient.
Description :
Wingless (Wg), a founding member of the Wingless/Int-1 (Wnt) family of secreted proteins, acts as a short-range inducer and as a long-range organizer during Drosophila development. Here, we determine the consequences of ectopically expressing (i) a wild-type form of Wg, (ii) a membrane-tethered form...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements.
Description :
The sevenless gene controls the fate of a single photoreceptor cell type in the developing eye of Drosophila. Its RNA and protein accumulate transiently in a subpopulation of cells in the developing eye imaginal disc. We have used P-element transformation with different minigenes and marker gene con...
Repository :
Europe PubMed Central
Language(s) :
English
A simple molecular complex mediates widespread BMP-induced repression during Drosophila development.
Description :
The spatial and temporal control of gene expression during the development of multicellular organisms is regulated to a large degree by cell-cell signaling. We have uncovered a simple mechanism through which Dpp, a TGFbeta/BMP superfamily member in Drosophila, represses many key developmental genes ...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis.
Description :
Differentiation of distinct cell types at specific locations within a developing organism depends largely on the ability of cells to communicate. A major class of signalling proteins implicated in cell to cell communication is represented by members of the TGF beta superfamily. A corresponding class...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK
Description :
BACKGROUND: The JNK pathway is a mitogen-activated protein (MAP) kinase pathway involved in the regulation of numerous physiological processes during development and in response to environmental stress. JNK activity is controlled by two MAPK kinases (MAPKK), Mkk4 and Mkk7. Mkk7 plays a prominent rol...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
A reverse genetic screen in Drosophila using a deletion-inducing mutagen.
Description :
We report the use of the cross-linking drug hexamethylphosphoramide (HMPA), which introduces small deletions, as a mutagen suitable for reverse genetics in the model organism Drosophila melanogaster. A compatible mutation-detection method based on resolution of PCR fragment-length polymorphisms on s...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English
Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.
Description :
Morphogen gradients control body pattern by differentially regulating cellular behavior. Here, we analyze the molecular events underlying the primary response to the Dpp/BMP morphogen in Drosophila. Throughout development, Dpp transduction causes the graded transcriptional downregulation of the brin...
Repository :
Zurich Open Repository and Archive (ZORA)
Language(s) :
English