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author = "Basler, K"
<< < 1 2 3 4 5 > >>

Found 49 documents, displaying page 2 of 5

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

Author(s) : Méthot, N , Basler, K
Description : Hedgehog (Hh) proteins play diverse organizing roles in development by regulating gene expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Hh target genes. A repressor form of Ci arises in the absence of Hh signaling by proteolytic...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Opposing transcriptional outputs of Hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P boundary.

Author(s) : Dahmann, C , Basler, K
Description : The wing imaginal disc is subdivided into two nonintermingling sets of cells, the anterior (A) and posterior (P) compartments. Anterior cells require reception of the Hedgehog (Hh) signal to segregate from P cells. We provide evidence that Hh signaling controls A/P cell segregation not by directly m...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing.

Author(s) : Burke, R , Basler, K
Description : The mammalian growth factor TGFbeta negatively regulates cell proliferation in various systems. Here we provide evidence that another TGFbeta superfamily member, Drosophila Decapentaplegic (Dpp), stimulates cell proliferation. In the developing wing blade, somatic clones lacking the Dpp receptors Pu...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Behandlungsergebnisse bei Morbus Scheuermann

Author(s) : Seifert, J , Basler, K
Description :
Repository : German Medical Science
Language(s) : German

Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin.

Author(s) : Hoffmans, R , Städeli, R , Basler, K
Description : Wnt signaling controls important aspects of animal development, and its deregulation has been causally linked to cancer. Transduction of Wnt signals entails the association of beta-catenin with nuclear TCF DNA binding proteins and the subsequent activation of target genes. The transcriptional activi...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing.

Author(s) : Zecca, M , Basler, K , Struhl, G
Description : The Drosophila wing is formed by two cell populations, the anterior and posterior compartments, which are distinguished by the activity of the selector gene engrailed (en) in posterior cells. Here, we show that en governs growth and patterning in both compartments by controlling the expression of th...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels

Author(s) : Schwank, G , Restrepo, S , Basler, K
Description : Morphogens can control organ development by regulating patterning as well as growth. Here we use the model system of the Drosophila wing imaginal disc to address how the patterning signal Decapentaplegic (Dpp) regulates cell proliferation. Contrary to previous models, which implicated the slope of t...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

The hedgehog signaling pathway: where did it come from?

Author(s) : Hausmann, G , von Mering, C , Basler, K
Description :
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Requirement for Pangolin/dTCF in Drosophila Wingless signaling.

Author(s) : Schweizer, L , Nellen, D , Basler, K
Description : The Wingless (Wg) protein is a secreted glycoprotein involved in intercellular signaling. On activation of the Wg signaling pathway, Armadillo is stabilized, causing target genes to be activated by the transcription factor Pangolin (Pan). This study investigated the roles of Pan in the developing wi...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily.

Author(s) : Moreno, E , Yan, M , Basler, K
Description : Much of what we know about apoptosis in human cells stems from pioneering genetic studies in the nematode C. elegans. However, one important way in which the regulation of mammalian cell death appears to differ from that of its nematode counterpart is in the employment of TNF and TNF receptor superf...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English
<< < 1 2 3 4 5 > >>

Found 49 documents, displaying page 2 of 5