Results
author = "Barr, Ian G."
In Vitro Generation of Neuraminidase Inhibitor Resistance in A(H5N1) Influenza Viruses▿
Description :
To identify mutations that can arise in highly pathogenic A(H5N1) viruses under neuraminidase inhibitor selective pressure, two antigenically different strains were serially passaged with increasing levels of either oseltamivir or zanamivir. Under oseltamivir pressure, both A(H5N1) viruses developed...
Repository :
Europe PubMed Central
Language(s) :
English
Rapid Detection and Subtyping of Human Influenza A Viruses and Reassortants by Pyrosequencing
Description :
Repository :
Europe PubMed Central
Language(s) :
English
MDCK-SIAT1 Cells Show Improved Isolation Rates for Recent Human Influenza Viruses Compared to Conventional MDCK Cells▿ †
Description :
The ability to isolate and propagate influenza virus is an essential tool for the yearly surveillance of circulating virus strains and to ensure accurate clinical diagnosis for appropriate treatment. The suitability of MDCK-SIAT1 cells, engineered to express increased levels of α-2,6-linked sialic a...
Repository :
Europe PubMed Central
Language(s) :
English
Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation▿
Description :
The neuraminidase inhibitors zanamivir and oseltamivir are marketed for the treatment and prophylaxis of influenza and have been stockpiled by many countries for use in a pandemic. Although recent surveillance has identified a striking increase in the frequency of oseltamivir-resistant seasonal infl...
Repository :
Europe PubMed Central
Language(s) :
English
Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
Author(s) :
Hurt, Aeron C.
,
Leang, Sook Kwan
,
Speers, David J.
,
Barr, Ian G.
,
Maurer-Stroh, Sebastian
Description :
Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M m...
Repository :
Europe PubMed Central
Language(s) :
English
Cross-Reactive Antibodies to Pandemic (H1N1) 2009 Virus, Singapore
Author(s) :
Tang, Julian W.
,
Tambyah, Paul A.
,
Wilder-Smith, Annelies
,
Puong, Kim-Yoong
,
Shaw, Robert
,
Barr, Ian G.
,
Chan, Kwai-Peng
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Assessing the Viral Fitness of Oseltamivir-Resistant Influenza Viruses in Ferrets, Using a Competitive-Mixtures Model ▿
Author(s) :
Hurt, Aeron C.
,
Nor'e, Siti Sarah
,
McCaw, James M.
,
Fryer, Helen R.
,
Mosse, Jennifer
,
McLean, Angela R.
,
Barr, Ian G.
Description :
To determine the relative fitness of oseltamivir-resistant strains compared to susceptible wild-type viruses, we combined mathematical modeling and statistical techniques with a novel in vivo “competitive-mixtures” experimental model. Ferrets were coinfected with either pure populations (100% suscep...
Repository :
Europe PubMed Central
Language(s) :
English
Rapid Detection of the H275Y Oseltamivir Resistance Mutation in Influenza A/H1N1 2009 by Single Base Pair RT-PCR and High-Resolution Melting
Author(s) :
Tong, Steven Y. C.
,
Dakh, Farshid
,
Hurt, Aeron C.
,
Deng, Yi-Mo
,
Freeman, Kevin
,
Fagan, Peter K.
,
Barr, Ian G.
,
Giffard, Philip M.
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Pandemic (H1N1) 2009 Risk for Frontline Health Care Workers
Author(s) :
Marshall, Caroline
,
Kelso, Anne
,
McBryde, Emma
,
Barr, Ian G.
,
Eisen, Damon P.
,
Sasadeusz, Joe
,
Buising, Kirsty
,
Cheng, Allen C.
Description :
To determine whether frontline health care workers (HCWs) are at greater risk for contracting pandemic (H1N1) 2009 than nonclinical staff, we conducted a study of 231 HCWs and 215 controls. Overall, 79 (17.7%) of 446 had a positive antibody titer by hemagglutination inhibition, with 46 (19.9%) of 23...
Repository :
Europe PubMed Central
Language(s) :
English
Neuraminidase Inhibitor-Resistant and -Sensitive Influenza B Viruses Isolated from an Untreated Human Patient
Author(s) :
Hurt, Aeron C.
,
Iannello, Pina
,
Jachno, Kim
,
Komadina, Naomi
,
Hampson, Alan W.
,
Barr, Ian G.
,
McKimm-Breschkin, Jennifer L.
Description :
An influenza B virus from an infant with no history of treatment or contact with neuraminidase inhibitors demonstrated a significant reduction in sensitivity to these drugs. Here, we describe the analysis of a mixed viral population that contained a novel D197E amino acid substitution that was respo...
Repository :
Europe PubMed Central
Language(s) :
English