Results
author = "Amos, William"
Heterozygosity increases microsatellite mutation rate, linking it to demographic history
Description :
Abstract
Background
Biochemical experiments in yeast suggest a possible mechanism that would cause heterozygous sites to mutate faster than equivalent homozygous sites. If such a process operates, it could undermine a key assumption at the core of population genetic theory, namely t...
Repository :
DOAJ-Articles
Language(s) :
English
Heterozygosity Increases Microsatellite Mutation Rate, Linking it to Demographic History
Description :
Background: Biochemical experiments in yeast suggest a possible mechanism that would cause heterozygous sites to mutate faster than equivalent homozygous sites. If such a process operates, it could undermine a key assumption at the core of population genetic theory, namely that mutation rate and pop...
Repository :
Digital Access to Scholarship at Harvard
Language(s) :
English
Heterozygosity increases microsatellite mutation rate, linking it to demographic history
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Does kin selection influence fostering behaviour in Antarctic fur seals (Arctocephalus gazella)?
Description :
A recent observation that female Antarctic fur seals foster pups born to related females raises the fascinating possibility that kin selection may promote altruistic behaviour even on a crowded breeding beach, where individual interactions are frequent and complex. However, the use of genetic marker...
Repository :
Europe PubMed Central
Language(s) :
English
Distance from Africa, not climate, explains within-population phenotypic diversity in humans
Description :
The relative importance of ancient demography and climate in determining worldwide patterns of human within-population phenotypic diversity is still open to debate. Several morphometric traits have been argued to be under selection by climatic factors, but it is unclear whether climate affects the g...
Repository :
Europe PubMed Central
Language(s) :
English
Microsatellite Length Differences Between Humans and Chimpanzees at Autosomal Loci Are Not Found at Equivalent Haploid Y Chromosomal Loci
Description :
When homologous microsatellites are compared between species, significant differences in mean length are often noted. A dominant cause of these length differences is ascertainment bias due to selection for maximum repeat number and repeat purity when the markers are being developed. However, even af...
Repository :
Europe PubMed Central
Language(s) :
English
Male heterozygosity predicts territory size, song structure and reproductive success in a cooperatively breeding bird.
Description :
Recent studies of non-social animals have shown that sexually selected traits signal at least one measure of genetic quality: heterozygosity. To determine whether similar cues reveal group quality in more complex social systems, we examined the relationship between territory size, song structure and...
Repository :
Europe PubMed Central
Language(s) :
English
Consanguinity and susceptibility to infectious diseases in humans
Description :
Studies of animal populations suggest that low genetic heterozygosity is an important risk factor for infection by a diverse range of pathogens, but relatively little research has looked to see whether similar patterns exist in humans. We have used microsatellite genome screen data for tuberculosis ...
Repository :
Europe PubMed Central
Language(s) :
English
An Empirical Exploration of the (δμ)2 Genetic Distance for 213 Human Microsatellite Markers
Author(s) :
Cooper, Gillian
,
Amos, William
,
Bellamy, Richard
,
Siddiqui, Mahveen Ruby
,
Frodsham, Angela
,
Hill, Adrian V. S.
Description :
Microsatellites are now used ubiquitously as genetic markers. One important application is to the assessment of population subdivision and phylogenetic relatedness. Such applications require a method of estimation of genetic distance. Here we examine the most widely used measure of microsatellite ge...
Repository :
Europe PubMed Central
Language(s) :
English
Markov Chain Monte Carlo analysis of human Y-chromosome microsatellites provides evidence of biased mutation
Author(s) :
Cooper, Gillian
,
Burroughs, Nigel J.
,
Rand, David A.
,
Rubinsztein, David C.
,
Amos, William
Description :
We describe a Markov Chain Monte Carlo analysis of five human Y- chromosome microsatellite polymorphisms based on samples from five diverse populations. Our analysis provides strong evidence for mutational bias favoring increase in length at all loci. Estimates of population coalescent times and pop...
Repository :
Europe PubMed Central
Language(s) :
English