Results
repositories = "University of Oulu Repository - Jultika"
> : "Oulun yliopisto, Lääketieteellinen tiedekunta, Lääketieteellisen biokemian ja molekyylibiologian laitos"
(x)
Type XIII collagen : organization and chromosomal localization of the mouse gene, distance between human COL13A1 and prolyl 4-hydroxylase α-subunit genes, and generation of mice expressing an N-terminally altered type XIII collagen
Author(s) :
Kvist, Ari-Pekka
Description :
Abstract
The complete exon-intron organization of the gene coding for the mouse α1(XIII) collagen chain, Col13a1, was characterized from genomic clones and multiple transcription initiation points were determined. Detailed comparison of the human and mouse genes showed that the exon-intron structur...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
From rare syndromes to a common disease : mutations in minor cartilage collagen genes cause Marshall and Stickler syndromes and intervertebral disc disease
Author(s) :
Annunen, Susanna
Description :
Abstract
Collagens IX and XI are quantitatively minor components of
the collagen fibrils in cartilage. The spectrum of the phenotypes
caused by mutations in the COL2A1 gene coding for collagen II, the
main cartilage collagen, is relatively well defined, but there is
little data on the phenotypes ca...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
The human COL9A3 gene : structure of the gene for the α3 chain of type IX collagen and its role in human cartilage and intervertebral disc diseases
Author(s) :
Paassilta, Petteri
Description :
Abstract
The nucleotide sequence of the entire COL9A3 gene, coding
for the human α3(IX) chain, was determined. The gene was
approximately 23 kb in length and consisted of 32 exons. The polymerase chain
reaction (PCR)-based procedure of conformation-sensitive gel electrophoresis
(CSGE) was used to s...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
Recombinant human collagens : characterization of type II collagen expressed in insect cells and production of types I-III collagen in the yeast Pichia pastoris
Author(s) :
Nokelainen, Minna
Description :
Abstract
An efficient system for expressing recombinant human collagens is expected to have numerous scientific and medical applications, but this is difficult to achieve because most systems do not have sufficient levels of activity of prolyl 4-hydroxylase, the key enzyme of collagen synthesis.
...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
Cellular energy state and calcium in myocardial substrate oxidation, ischemia and preconditioning
Author(s) :
Ala-Rämi, Antti
Description :
Abstract
The processes affecting myocardial survival in ischemia were studied in perfused rat hearts by using largely non-invasive methods based on optical monitoring and nuclear magnetic resonance (NMR).
Ischemic preconditioning (IPC) has been shown to protect the heart considerably from ischemic...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
Type XVIII collagen : characterization of the primary structure and expression pattern of different variants in Xenopus laevis, characterization of the human gene structure and analysis of transgenic mice expressing endostatin
Author(s) :
Elamaa, Harri
Description :
Abstract
In this work the type XVIII collagen has been studied by using several approaches, such as different animal models. The primary structure of frog, Xenopus laevis, type XVIII collagen and the expression pattern of its variants during early embryogenesis have been elucidated. The gene struct...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
Characterization of the novel human prolyl 4-hydroxylases and asparaginyl hydroxylase that modify the hypoxia-inducible factor
Author(s) :
Hirsilä, Maija
Description :
Abstract
HIF prolyl 4-hydroxylases (HIF-P4Hs) and HIF asparaginyl hydroxylase (FIH) are novel members of the 2-oxoglutarate dioxygenase family that play key roles in the regulation of the hypoxia-inducible transcription factor (HIF). They hydroxylate specific proline and asparagine residues in HIF-...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
Type XIII collagen : organization of the mouse gene, generation of three genetically engineered mouse lines by homologous recombination, and biochemical studies on the molecular properties of the type XIII collagen protein
Author(s) :
Latvanlehto, Anne
Description :
Abstract
Genomic clones covering the entire mouse type XIII collagen gene (Col13a1) were isolated, and the complete exon-intron organization was characterized. The gene was found to be about 135 kb in size and to locate in the mouse chromosome 10. Comparison of gene structures and promoter regions ...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
Spinal stenosis and intervertebral disc disease : the role of sequence variations in collagen IX and XI, and inflammatory factors in spinal disorders
Author(s) :
Noponen-Hietala, Noora
Description :
Abstract
Genetic factors have been implicated to play a role in both degenerative lumbar spinal stenosis (LSS) and intervertebral disc disease (IDD). Sequence variations in the genes coding for collagen IX and inflammatory mediators have been indicated as risk factors for IDD.
Nine genes coding fo...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined
Genetic factors in bone disorders : osteogenesis imperfecta, juvenile osteoporosis and stress fractures
Author(s) :
Hartikka, Heini
Description :
Abstract
Genetic factors and their resulting phenotypes were evaluated in three different bone disorders: osteogenesis imperfecta (OI), juvenile idiopathic osteoporosis (JIO), and stress fractures.
The spectrum of the OI phenotypes caused by mutations in the COL1A1 and COL1A2 genes is well defined...
Repository :
University of Oulu Repository - Jultika
Language(s) :
Undetermined