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• (author = "van der Horst, Gijsbertus T. J." AND subject = "DNA Dynamics and Chromosome Structure")
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author = "van der Horst, Gijsbertus T. J." > : "DNA Dynamics and Chromosome Structure" (x)
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Found 3 documents, displaying page 1 of 1

Disruption of the Cockayne Syndrome B Gene Impairs Spontaneous Tumorigenesis in Cancer-Predisposed Ink4a/ARF Knockout Mice

Author(s) : Lu, Yi , Lian, Hanzhou , Sharma, Prerna , Schreiber-Agus, Nicole , Russell, Robert G. , Chin, Lynda , van der Horst, Gijsbertus T. J.
Description : Cells isolated from individuals with Cockayne syndrome (CS) have a defect in transcription-coupled DNA repair, which rapidly corrects certain DNA lesions located on the transcribed strand of active genes. Despite this DNA repair defect, individuals with CS group A (CSA) or group B (CSB) do not exhib...
Repository : Europe PubMed Central
Language(s) : English

Different Effects of CSA and CSB Deficiency on Sensitivity to Oxidative DNA Damage

Author(s) : de Waard, Harm , de Wit, Jan , Andressoo, Jaan-Olle , van Oostrom, Conny T. M. , Riis, Bente , Weimann, Allan , Poulsen, Henrik E.
Description : Mutations in the CSA and CSB genes cause Cockayne syndrome, a rare inherited disorder characterized by UV sensitivity, severe neurological abnormalities, and progeriod symptoms. Both gene products function in the transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER), prov...
Repository : Europe PubMed Central
Language(s) : English

Developmental Defects and Male Sterility in Mice Lacking the Ubiquitin-Like DNA Repair Gene mHR23B

Author(s) : Ng, Jessica M. Y. , Vrieling, Harry , Sugasawa, Kaoru , Ooms, Marja P. , Grootegoed, J. Anton , Vreeburg, Jan T. M.
Description : mHR23B encodes one of the two mammalian homologs of Saccharomyces cerevisiae RAD23, a ubiquitin-like fusion protein involved in nucleotide excision repair (NER). Part of mHR23B is complexed with the XPC protein, and this heterodimer functions as the main damage detector and initiator of global genom...
Repository : Europe PubMed Central
Language(s) : English
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Found 3 documents, displaying page 1 of 1