Results
author = "van der Horst, Gijsbertus T. J."
> : "English"
(x)
Functional Evolution of the Photolyase/Cryptochrome Protein Family: Importance of the C Terminus of Mammalian CRY1 for Circadian Core Oscillator Performance†
Author(s) :
Chaves, Inês
,
Yagita, Kazuhiro
,
Barnhoorn, Sander
,
Okamura, Hitoshi
,
van der Horst, Gijsbertus T. J.
,
Tamanini, Filippo
Description :
Cryptochromes (CRYs) are composed of a core domain with structural similarity to photolyase and a distinguishing C-terminal extension. While plant and fly CRYs act as circadian photoreceptors, using the C terminus for light signaling, mammalian CRY1 and CRY2 are integral components of the circadian ...
Repository :
Europe PubMed Central
Language(s) :
English
Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne Syndrome Group B DNA repair genes
Author(s) :
Murai, Machiko
,
Enokido, Yasushi
,
Inamura, Naoko
,
Yoshino, Masafumi
,
Nakatsu, Yoshimichi
,
van der Horst, Gijsbertus T. J.
Description :
Xeroderma pigmentosum (XP) and Cockayne syndrome (CS) are rare autosomal recessive disorders associated with a defect in the nucleotide excision repair (NER) pathway required for the removal of DNA damage induced by UV light and distorting chemical adducts. Although progressive neurological dysfunct...
Repository :
Europe PubMed Central
Language(s) :
English
Disruption of the Cockayne Syndrome B Gene Impairs Spontaneous Tumorigenesis in Cancer-Predisposed Ink4a/ARF Knockout Mice
Author(s) :
Lu, Yi
,
Lian, Hanzhou
,
Sharma, Prerna
,
Schreiber-Agus, Nicole
,
Russell, Robert G.
,
Chin, Lynda
,
van der Horst, Gijsbertus T. J.
Description :
Cells isolated from individuals with Cockayne syndrome (CS) have a defect in transcription-coupled DNA repair, which rapidly corrects certain DNA lesions located on the transcribed strand of active genes. Despite this DNA repair defect, individuals with CS group A (CSA) or group B (CSB) do not exhib...
Repository :
Europe PubMed Central
Language(s) :
English
Measurement of internal body time by blood metabolomics
Author(s) :
Minami, Yoichi
,
Kasukawa, Takeya
,
Kakazu, Yuji
,
Iigo, Masayuki
,
Sugimoto, Masahiro
,
Ikeda, Satsuki
,
Yasui, Akira
Description :
Detection of internal body time (BT) via a few-time-point assay has been a longstanding challenge in medicine, because BT information can be exploited to maximize potency and minimize toxicity during drug administration and thus will enable highly optimized medication. To address this challenge, we ...
Repository :
Europe PubMed Central
Language(s) :
English
Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock
Author(s) :
Engelen, Erik
,
Janssens, Roel C.
,
Yagita, Kazuhiro
,
Smits, Veronique A. J.
,
van der Horst, Gijsbertus T. J.
,
Tamanini, Filippo
Description :
The transcription/translation feedback loop-based molecular oscillator underlying the generation of circadian gene expression is preserved in almost all organisms. Interestingly, the animal circadian clock proteins CRYPTOCHROME (CRY), PERIOD (PER) and TIMELESS (TIM) are strongly conserved at the ami...
Repository :
Europe PubMed Central
Language(s) :
English
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice
Description :
Many biochemical, physiological, and behavioral processes display daily rhythms generated by an internal timekeeping mechanism referred to as the circadian clock. The core oscillator driving this clock is located in the ventral part of the hypothalamus, the so called suprachiasmatic nuclei (SCN). At...
Repository :
Europe PubMed Central
Language(s) :
English
Loss of circadian rhythmicity in aging mPer1-/- mCry2-/- mutant mice
Description :
The mPer1, mPer2, mCry1, and mCry2 genes play a central
role in the molecular mechanism driving the central pacemaker of the mammalian
circadian clock, located in the suprachiasmatic nuclei (SCN) of the
hypothalamus. In vitro studies suggest a close interaction of all mPER and
mCRY proteins. We ...
Repository :
Europe PubMed Central
Language(s) :
English
Flexible phase adjustment of circadian albumin D site-binding protein (Dbp) gene expression by CRYPTOCHROME1
Author(s) :
Stratmann, Markus
,
Stadler, Frédéric
,
Tamanini, Filippo
,
van der Horst, Gijsbertus T.J.
,
Ripperger, Jürgen A.
Description :
The albumin D site-binding protein (DBP) governs circadian transcription of a number of hepatic detoxification and metabolic enzymes prior to the activity phase and subsequent food intake of mice. However, the behavior of mice is drastically affected by the photoperiod. Therefore, continuous adjustm...
Repository :
Europe PubMed Central
Language(s) :
English
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein
Author(s) :
Yagita, Kazuhiro
,
Tamanini, Filippo
,
Yasuda, Maya
,
Hoeijmakers, Jan H.J.
,
van der Horst, Gijsbertus T.J.
,
Okamura, Hitoshi
Description :
The core oscillator generating circadian rhythms in eukaryotes is composed of transcription–translation-based autoregulatory feedback loops in which clock gene products negatively affect their own expression. A key step in this mechanism involves the periodic nuclear accumulation of clock proteins f...
Repository :
Europe PubMed Central
Language(s) :
English
Different Effects of CSA and CSB Deficiency on Sensitivity to Oxidative DNA Damage
Author(s) :
de Waard, Harm
,
de Wit, Jan
,
Andressoo, Jaan-Olle
,
van Oostrom, Conny T. M.
,
Riis, Bente
,
Weimann, Allan
,
Poulsen, Henrik E.
Description :
Mutations in the CSA and CSB genes cause Cockayne syndrome, a rare inherited disorder characterized by UV sensitivity, severe neurological abnormalities, and progeriod symptoms. Both gene products function in the transcription-coupled repair (TCR) subpathway of nucleotide excision repair (NER), prov...
Repository :
Europe PubMed Central
Language(s) :
English